Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Abstract

D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high-energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers.

Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects

“…In the dose range studied, D‐ribose had no discernible effect on uric acid. Differing results have been published on whether D‐Ribose administration leads to moderate increases in uric acid levels . While the 2.5 g fasting dose had minimal effect on serum glucose, the 5.0 and 10.0 g fasting doses showed appreciable, dose‐related decreases in the first 60 minutes post dose.…”

Understanding D-Ribose and Mitochondrial Function

“…It is readily metabolized if consumed within 30 minutes after being mixed in fluid. The side effects are minimal, but patients have reported mild diarrhea, slight nausea, and stomach discomfort that was reduced by consuming the drink with food ( 45 – 47 ). There had been some concerns about the safety of ribose therapy related to the inhibitory effects of ribose on cell proliferation in vitro.…”

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

“…SUA levels showed a positive correlation with clinical improvement (p=0.02) and acted as an independent predictor for favorable stroke outcome (p=0.04) in the thrombolysis group. SUA was increased [5] on day 7 but had decreased to baseline values by day 14 in subjects who ingested 20 gr/day of ribose. After [6] a strenuous IR period, uric acid is taken up by the muscle, acting as the main source of plasma hypoxanthine in the blood.…”