Assessment of hematological, biochemical effects and genotoxicity among pesticide sprayers in grape garden

Gaikwad, Avinash S; Karunamoorthy, Panjakumar; Kondhalkar, Shridhar; Ambikapathy, Mala; Ravichandran, Beerappa

doi:10.1186/s12995-015-0049-6

Cited by 44 publications

(27 citation statements)

References 16 publications

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“…Results from the current report regarding pesticide use and hematological parameters are consistent with previous studies which failed to reveal a consistent relationship between pesticide exposure and hematological parameters among farmers 21,27,28 . Thus, a Thai study with orchid farmers found no significant differences in hematological parameters between subjects highly exposed to pesticides and non-exposed subjects 21 .…”

Section: Pesticide Use and Hematological Parameterssupporting

confidence: 90%

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Piccoli

Cremonese

Koifman

et al. 2019

Ciênc. saúde coletiva

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This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.

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Section: Pesticide Use and Hematological Parameterssupporting

confidence: 90%

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Piccoli

Cremonese

Koifman

et al. 2019

Ciênc. saúde coletiva

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“…After DDT absorption, it is distributed to all organs and a portion will be stored in fatty tissues, especially if the exposure was massive [141][142][143][144][145][146] . Many insecticides, including DDT, were reported to be responsible for leading the development of HCC [147][148][149][150][151][152] .…”

Section: Pesticidesmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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“…Toxicity depends on the compound family, and is generally greater for the older compounds. In humans, pesticides are responsible for acute poisonings, as well as long-term health effects, including cancer and adverse effects on reproduction (78,79,190). …”

Section: Resultsmentioning

confidence: 99%

Non-infective occupational risk factors for hepatocellular carcinoma: A review

Ledda

Loreto

Zammit

et al. 2016

Molecular Medicine Reports

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Liver cancer is the second leading worldwide cause of cancer-associated mortalities. Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among types of human cancer. Well-established risk factors for liver cancer include the hepatitis B and C viruses, aflatoxins, alcohol consumption, and oral contraceptives. Tobacco smoking, androgenic steroids, and diabetes mellitus are suspected risk factors. Current knowledge regarding non-infective occupational risk factors for liver cancer is inconclusive. The relevance of liver disorders to occupational medicine lies in the fact that the majority of chemicals are metabolized in the liver, and toxic metabolites generated via metabolism are the predominant cause of liver damage. However, their non-specific clinical manifestations that are similar in a number of liver diseases make diagnosis difficult. Furthermore, concomitant conditions, such as viral hepatitis and alcohol or drug abuse, may mask liver disorders that result from occupational hepatotoxic agents and block the demonstration of an occupational cause. The identification of environmental agents that result in human cancer is a long and often difficult process. The purpose of the present review is to summarize current knowledge regarding the association of non-infective occupational risk exposure and HCC, to encourage further research and draw attention to this global occupational public health problem.

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Assessment of hematological, biochemical effects and genotoxicity among pesticide sprayers in grape garden

Cited by 44 publications

References 16 publications

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Hepatocellular carcinoma and the risk of occupational exposure

Non-infective occupational risk factors for hepatocellular carcinoma: A review

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