Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium

Geens, Tinne; Roosens, Laurence; Neels, Hugo; Covaci, Adrian

doi:10.1016/j.chemosphere.2009.05.024

Cited by 227 publications

(146 citation statements)

References 24 publications

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“…Several biomonitoring studies from different countries have shown that BPA is present in human biological fluids such as urine (Yang et al 2003;Arakawa et al 2004;Völkel et al 2008Völkel et al , 2011Geens et al 2009;He et al 2009;Health Canada 2010), milk (Kuruto-Niwa et al 2007;Ye et al 2008), blood (He et al 2009;Cobellis et al 2009;Geens et al 2009), and follicular and amniotic fluid (Ikezuki et al 2002). Urine is a widely used biological sample for biomonitoring to quantify human exposure to BPA, with a biological halflife in humans of less than 6 h (Völkel et al 2002).…”

Section: Resultsmentioning

confidence: 98%

Determination of urinary levels of Bisphenol A in a Turkish population

Battal

Çok

Unlusayin

et al. 2014

Environ Monit Assess

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Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals that is widely used in common consumer products. The aim of this study was to report the total urinary BPA concentrations (free plus conjugated) in 200 urine samples (children: 57; male: 74; female: 69) obtained from residents of a Mediterranean city, Mersin. Analyses were performed by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and for assessing environmental exposure to free BPA and its major metabolite bisphenol A glucuronide (BPAG) in human urine were determinated. Our results indicated that the free BPA and BPAG concentrations were in the range of 0.06-0.99 μg/g creatinine and 0.24-615 μg/g creatinine, respectively. No statistically significant difference obtained in BPA concentrations between genders (male and female) or domicile of residence (rural and urban) (p > 0.05). In our study, the mean level of detected free BPA was 0.46 μg/g creatinine in the urban area and 0.37 μg/g creatinine in the rural area. The average amount of BPAG was 60.56 μg/g creatinine in the urban area and 30.28 μg/g creatinine in the rural area. The data demonstrate that determined amount of total BPA in the present study is lower than the results of similar studies conducted in developed countries. There is no data about the levels of BPA in humans and environment in Turkey. Because of this reason, present study is very important since it is the first study in Turkey which determined the concentrations of free BPA and total BPA in human.

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Section: Resultsmentioning

confidence: 98%

Determination of urinary levels of Bisphenol A in a Turkish population

Battal

Çok

Unlusayin

et al. 2014

Environ Monit Assess

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“…All glassware was washed with detergent, rinsed with Milli-Q (Millipore, France) ultrapure water, dried at 150°C, and rinsed with n-hexane before use. Human serum was analyzed for levels of BPA as described (Geens et al 2009a(Geens et al , 2009b. Briefly, 1 mL of serum was fortified with 2.50 ng of carbon-13 ( 13 C)-labeled internal standard.…”

Section: Sample Preparationmentioning

confidence: 99%

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

Zhuang

Wang

et al. 2014

Arch Environ Contam Toxicol

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Bisphenol-A (BPA) can alter endocrine function in animals, yet the relationship between human exposure to BPA and male reproductive function is not well understood. We collected serum samples from 281 male workers exposed to BPA and 278 controls. Serum BPA concentrations were analyzed by gas chromatography-mass spectrometry after derivatization. The serum levels of sex hormone-binding globulin (SHBG) and total testosterone (TT) were detected by radioimmunoassay and levels of inhibin B (INB) and androstenedione (AD) by enzyme-linked immunosorbent assay. We examined the association of BPA exposure and male sex hormone levels by multivariable linear regression. Both serum BPA concentrations and detection rates were greater in males exposed than those not exposed to BPA, but the two groups did not differ in levels of SHBG, TT, INB, or AD. Compared with exposure for ≤5 years, exposure for >5 years was associated with increased serum BPA and SHBG 1evels and decreased AD levels. Compared with undetectable BPA and BPA ≤ 18.75 ng/mL, BPA level >18.75 ng/mL was associated with low AD and high SHBG levels (P < 0.05). On adjusted multivariable regression, increased serum BPA level was associated with decreased mean serum AD level (0.18 ng/mL; 95% confidence interval CI -0.22 to -0.13) and increased mean serum SHBG level (2.79 nmol/L; 95% CI 2.11-3.46). Serum BPA levels were increased after occupational exposure. BPA exposure was negatively associated with serum AD level but positively associated with serum SHBG level.

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“…The use of BPA in food packaging, along with the ability of BPA to leach into the food (7) , has led many to believe that diet is a major route of human BPA exposure (7)(8)(9)(10)(11)(12) . BPA has also been found in products made from recycled paper (21) , dust particles (22)(23)(24) , thermal receipt paper (25,26) , soil, tap water and surface water (27)(28)(29)(30)(31)(32) .…”

mentioning

confidence: 99%

Bisphenol A exposure and associations with obesity among adults: a critical review

Oppeneer

Robien

2014

Public Health Nutr.

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Objective: To review the literature on bisphenol A (BPA) exposure and obesity in human populations. Design: Systematic review of the literature via searches of PubMed, EMBASE, Web of Science and reference lists for articles published to 1 August 2014. Setting: China, Italy, Japan, Republic of Korea, Sweden, UK, USA. Subjects: Adults (≥18 years). Results: Eighteen articles were identified and included in the review. Twelve studies included secondary evaluations of BPA exposure and BMI, and six studies evaluated body composition as the primary outcome. All analyses were crosssectional and no study included in the review received a positive quality rating (twelve negative, six neutral). Eight studies observed a statistically significant positive association between urinary or serum BPA levels and BMI, and ten studies observed no association. Studies where BMI was a primary outcome and studies of neutral quality were more likely to observe an association. Conclusions: Study results are conflicting and significant methodological issues limit the ability to draw conclusions from these studies. Prospective studies that measure BPA exposure and changes in body weight and composition are needed to establish temporality, causality and the direction of any observed associations.

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Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium

Cited by 227 publications

References 24 publications

Determination of urinary levels of Bisphenol A in a Turkish population

Determination of urinary levels of Bisphenol A in a Turkish population

Association of Serum Bisphenol-A Concentration and Male Reproductive Function Among Exposed Workers

Bisphenol A exposure and associations with obesity among adults: a critical review

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