Assessment of immunomodulating activity of ofloxacin and three other quinolones in human plasma

Abstract

A time-dependent degree of immunosuppression or immunostimulation which may be correlated to pharmacokinetic variables was obtained by administering a single dose of ofloxacin, norfloxacin, pipemidic and piromidic acid to healthy volunteers. The plasma samples collected before drug administration and then at various time intervals were tested for their immunomodifying activity by employing a modified 2-way mixed lymphocyte reaction and a PMN chemotactic assay. Our results show that some of the quinolones tested--norfloxacin, pipemidic acid, piromidic acid--have an immunosuppressive activity.

Exocellular products from Bifidobacterium adolescentis as immunomodifiers in the lymphoproliferative responses of mouse splenocytes

“…Regarding the identification of the bifidobacterial components with immunodificative ability [2,9,10,23] our results suggest the carbohydrate-rich components may be responsible for modification of the immune response. This could take place as a consequence of their interaction with intestinal epithelial cells, as reported for the bifidobacterial lipoteichoic acid [2].…”