Assessment of impact factors on shear wave based liver stiffness measurement

Ling, Wenwu; Lu, Qiang; Quan, J.; Ma, Lin; Luo, Yan

doi:10.1016/j.ejrad.2012.10.004

Cited by 73 publications

(88 citation statements)

References 23 publications

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“…Liver-stiffness measurements obtained during different breathing phases were described in previous papers where patients were asked to hold their breath [15][16][17]. The authors of those studies considered the same two breathing phases and found that liver stiffness at end-expiration was significantly higher than that at end-inspiration.…”

Section: Discussionmentioning

confidence: 99%

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Pellot‐Barakat

Chami

Corréas

et al. 2016

European Journal of Radiology

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International audienceThis study was undertaken to evaluate the impact of free-breathing (FB) vs. Apnea on Shear-wave elastography (SWE) measurements.Quantitative liver-stiffness measurements were obtained during FB and Apnea for 97 patients with various body-morphologies and liver textures. Quality indexes of FB and Apnea elasticity maps (percentage of non-filling (PNF), temporal (TV) and spatial (SV) variabilities) were computed. SWE measurements were also obtained from an homogeneous phantom at rest and during a mechanically-induced motion.Liver-stiffness values estimated from FB and Apnea acquisitions were correlated, particularly for homogeneous livers (r = 0.76, P < 0.001) and favorable body-morphologies (r = 0.68, P < 0.001). However FB values were consistently 20–25% lower than Apnea ones (P < 0.001). FB also systematically resulted in degradation of TV (P < 0.005) and PNF (P < 0.001) compared to Apnea but had no impact on SV. With the phantom, no differences between SWE measurements at rest and during motion were observed.Apnea and FB measurements are highly correlated, although FB data quality is degraded compared to Apnea and estimated stiffness in FB is systematically lower than in Apnea. These discrepancies between rest and motion states were observed for patients but not for phantom data, suggesting that patient breath-holding impacts liver stiffness

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Section: Discussionmentioning

confidence: 99%

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Pellot‐Barakat

Chami

Corréas

et al. 2016

European Journal of Radiology

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“…Ten valid LS measurements can be obtained in more than 95% of patients [101][102][103]. There is no information about the learning curve of this method, but similar with ARFI elastography, considering the excellent feasibility in the few published studies, probably a special training is not needed for physicians with basic knowledge in liver ultrasonography.…”

Section: Feasibility and Reproducibilitymentioning

confidence: 97%

“…According to published data [101], LS measurements by ElastPQ should be performed in the liver segment V, because the lowest variation of LS measurements was observed in this location.…”

Section: B) Elastpq Technique Examination Techniquementioning

confidence: 99%

Romanian national guidelines and practical recommendations on liver elastography

et al. 2014

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The use of liver elastography has substantially developed in the past few years; the introduction of novel elastographic methods (Transient Elastography, point Shear Wave Elastography, Real Time Shear Wave Elastography, Strain Elastography) has changed the perspective in the evaluation of liver disease. The ongoing research in this area is mainly focused on diffuse liver diseases and for predicting liver cirrhosis complication. This guideline created under the auspice of Romanian Society of Ultrasound in Medicine and Biology is intended to accustomize the clinician with the current practical use of liver elastography and has been issued to help in maximizing the clinical benefit for the patients with chronic liver diseases.

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“…Previously, Ling et al [20] had revealed significant impacts as liver location, breathing phase, and gender on ElastPQ measurement. Park et al [26] found the overall intraobserver reproducibility of SWE in evaluation of FLLs can be affected by lesion depth.…”

Section: Discussionmentioning

confidence: 99%

“…However, only a few data are available so far for ElastPQ technology in evaluation of FLLs [20][21][22][23]. Our prospective study aims to evaluate the feasibility of ElastPQ techniques in the differential diagnosis and characterization of histologically proved FLLs.…”

Section: Introductionmentioning

confidence: 99%

Aim: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard. Material and methods: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated. Receiver operating characteristic (ROC) curve

Wang

et al. 2017

Med Ultrason

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Aim: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard.Material and methods: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic performance. Histology as a gold standard was obtained by surgery in all patients.Results: A total of 154 lesions including 129 (83.7 %) malignant FLLs and 25 (16.3 %) benign ones were analysed. The SWS of malignant and benign FLLs was significantly different, 2.77±0.68 m/s and 1.57±0.55 m/s (p<0.05). The SWS ratio of each FLL to surrounding liver parenchyma was 2.23±0.49 for malignant and 1.14±0.36 for benign FLLs (p<0.05). The cut off value for differential diagnosis was 2.06 m/s for SWS and 1.67 for SWS ratio.Conclusions: ElastPQ measurement provides reliable quantitative stiffness information of FLLs and may be helpful in the differential diagnosis between malignant and benign FLLs.

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Assessment of impact factors on shear wave based liver stiffness measurement

Cited by 73 publications

References 23 publications

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Romanian national guidelines and practical recommendations on liver elastography

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