Assessment of in vivo estrogenic response and the identification of environmental estrogens in the Yangtze River (Nanjing section)

Determination of estrogens and estrogenic activities in water from three rivers in Tianjin, China

“…Diethylstilbestrol and estradiol valerate which were hardly studied by others were not involved. In Yangtze River in China, concentrations of estrone, 17β-estradiol and estriol were up to 3.80, 0.97 and 5.79 ng/L, respectively (Lu et al, 2010). The concentrations of estrone and 17β-estradiol found in Tama River in Japan were up to 19.7 and 5.1 ng/L, respectively (Kawaguchi et al, 2004).…”

“…The three rivers flowing through Tianjin city are very important channels to carry sewage from Tianjin into the Bohai Sea. Six estrogens including estrone, 17β-estradiol, 17α-ethinylestradiol, estriol, diethylstilbestroland estradiol valerate (Lu et al, 2010), which were most frequently discovered EDCs in water bodies of China, were selected. To identify the main contributors to the estrogenic activities of the rivers, 17β-estradiol equivalent (EEQ) approach was introduced in the present study (Ra et al, 2011).…”

Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay

“…However, if a variety of ligands exist simultaneously, the behavior between them and ERs may change due to their different concentrations and receptor binding abilities, both of which are critical influences on the final effects. The nine selected substances have frequently been found, by chemical analysis, at relatively high concentrations in the aquatic system of China, and all of them have been associated with endocrine disrupting effects (Gong et al, 2012;Lei et al, 2009;Liu et al, 2012;Lu et al, 2010;Sun et al, 2008;Wang et al, 2012;Yan et al, 2012;Ye et al, 2012). Thus, we chose them as representative estrogen-like chemicals that are present in the water environment.…”

Water exposure assessment of aryl hydrocarbon receptor agonists in Three Gorges Reservoir, China using SPMD-based virtual organisms

“…However, the results of low concentrations of those compounds in TGR from the conventional chemical analysis cannot explain the fish decline in TGR. Studies (Lu et al, 2010;Shi et al, 2011) demonstrated that local populations of the Yangtze fish might be exposed to endocrine-disrupting chemicals at concentrations sufficient to cause impairment of their reproductive physiology. Our recent study reported detectable level of AhR activity in the sediment of TGR which provided possible weight-of-evidence of potential ecotoxicological cause for the decline of fish populations in TGR (Wang et al, 2014a).…”