Assessment of in vivo experiments: The newly synthesized porphyrin with proper light source enhanced effectiveness of PDT comparing to 5-ALA-mediated PDT

Jurczyszyn, Kamil; Woźniak, Marta; Symonowicz, Krzysztof; Sprutta, Natasza; Latos‐Grażyński, Lechosław; Ziółkowski, Piotr; Ivonyak, Yurii; Tuchowski, Piotr; Trzeciakowski, Witold

doi:10.1016/j.pdpdt.2017.02.014

Cited by 10 publications

(3 citation statements)

References 33 publications

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“…This permits surgeons to detect movement of fluids, uptake of molecules, blockage, breakages, etc. Similarly, blue spectrum lighting can be utilized to identify tumor cells when patients are administered a photosensitizer, 5-aminolevulinic acid (5-ALA), to differentiate cancerous tissue from normal tissue [31,32]. Light at the wavelength of 494 nm can excite fluorescein fluorophore for intra-operative separation of tumor tissue from normal stromal tissue [33,34], allowing the surgeon to identify cancerous tissue.…”

Section: Discussionmentioning

confidence: 99%

A Soft, Biocompatible Magnetic Field Enabled Wireless Surgical Lighting Patty for Neurosurgery

et al. 2020

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General surgical procedures are subject to low-light conditions or a narrow angle of view, and such limitations in light limit visibility and complicate the given surgical procedure. Conventional lighted surgical tools rely on an external light source, which may be oriented into a cavity or mounted on a surgical instrument such as retractor, endoscopes, or suction tubes. However, such conventional lighted instruments do not provide adequate lighting during various surgical procedures. Here, we present a soft, miniaturized magnetic-enabled wireless surgical lighting patty. Specifically, the proposed surgical lighting patty that can be temporarily implanted into a cavity or surgical corridor provides lighting to the surgical subject and manages fluids in a surgical field. The surgical lighting patty is a multilayer patty, two outer layers of the lighted surgical patty and the center lighted layer. A reed switch in the central layer can activate the power supply in response to a magnet to emit the light from the light source. The result allows a dramatically simplified wireless operation. Moreover, it can provide various wavelengths of light to a surgical field for purposes such as illuminating the surgeon’s field of vision, exciting dyes, and sterilizing surgical fields.

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Section: Discussionmentioning

confidence: 99%

A Soft, Biocompatible Magnetic Field Enabled Wireless Surgical Lighting Patty for Neurosurgery

et al. 2020

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“…The applications of porphyrins as anti-cancer Photodynamic Therapy (cPDT) agents have been extensively researched upon. 35,37,[44][45][46] Several research groups have devised porphyrin-based photosensitisers (PSs) [36][37][47][48] and multifunctional nanoparticles (NPs) 37,[49][50][51][52] that have shown promising results in treating specific cancer cells in vitro as well as in vivo. Parallel to the development of cPDT, in the last decade, another potential application of porphyrins has gained ground in the form of antimicrobial photodynamic therapy (aPDT).…”

Section: Anti-microbial Photodynamic Therapymentioning

confidence: 99%

Porphyrins in Photodynamic Therapy: A Review

Sharma,

Sengupta

2023

Preprint

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Porphyrins have emerged as versatile and highly effective photosensitizers in the field of photodynamic therapy (PDT). This promising therapeutic approach relies on the light-induced generation of reactive oxygen species (ROS) by photosensitizing agents. This comprehensive review explores the multifaceted role of porphyrins across various PDT applications, encompassing anticancer PDT, immuno-PDT, antimicrobial PDT, and antiviral PDT. Porphyrins exhibit the potential to serve as organic supramolecular platforms for developing various photosensitizers (PSs) tailored for specific PDT modalities. The exceptional capacity of porphyrins to specifically accumulate in target cancer cells or microorganisms, their proficiency in generating ROS upon exposure to light, and their capability to amass within cell mitochondria to facilitate apoptosis establish porphyrins as invaluable assets in a wide array of therapeutic applications. Ongoing research endeavours and clinical investigations continually unveil the vast potential of porphyrin-based PDT in combatting a wide range of diseases, spanning from cancer and infections to viral ailments. Furthermore, porphyrins hold promise in addressing drug-resistant cancers and antimicrobial resistance through non-invasive PDT, offering efficient alternatives to commercially available PDT drugs. In the context of advanced cancer management, porphyrin-based PDT offers the prospect of combinatorial therapy, enabling a sequence of immunogenic post-PDT actions that can effectively overcome anticancer resistance and tackle metastatic cancers. The future of PDT appears promising, with porphyrin scaffolds expected to play pivotal roles in advancing this field.

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“…It eventually led to necrosis or apoptosis of tumor cells [22,23]. So far, many photosensitizers including the first generation [24,25], the second generation [26][27][28], and the third generation photosensitizers [29,30] have been researched. Among these PSs, porphyrin-based PSs have a strong absorption band around 400 nm called the 'Soret' band and a satellite absorption band (Q-band) between 600 and 800 nm.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of porphyrin-conjugated silica-coated Au nanorods for synergistic photothermal therapy and photodynamic therapy of tumor

Zhang

Zhao

et al. 2019

Nanotechnology

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Synergistic therapy of tumor has attracted the attention of an increasing number of researchers because of its higher efficiency compared to single therapy. Herein, 4-carboxyphenyl porphyrin-conjugated silica-coated gold nanorods (AuNR@SiO2-TCPP) were synthesized. The synergistic treatment of photothermal therapy and photodynamic therapy on A549 cancer was researched in vivo and in vitro. In the AuNR@SiO2-TCPP, Au NRs and TCPP act as photothermal agent and photosensitizer, respectively. The temperature of the AuNR@SiO2-TCPP (0.11 nmol L−1) rises to 56.8 °C for 10 min under the illumination of 808 nm laser (2 Wcm−2). In MTT assays, the viability of A549 cancer cell treated with AuNR@SiO2-TCPP (100 μg ml−1) is only 21%. In animal experiments, the relative tumor volumes in mice receiving AuNR@SiO2-TCPP (5 mg kg−1) with 660 and 808 nm irradiations were significantly inhibited and the average value is decreased to 0.78 while the average value of the control group is increased to 7.2. These results demonstrate that the AuNR@SiO2-TCPP is a potential nanomedicine against tumor for clinical application in the near future.

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Assessment of in vivo experiments: The newly synthesized porphyrin with proper light source enhanced effectiveness of PDT comparing to 5-ALA-mediated PDT

Cited by 10 publications

References 33 publications

A Soft, Biocompatible Magnetic Field Enabled Wireless Surgical Lighting Patty for Neurosurgery

A Soft, Biocompatible Magnetic Field Enabled Wireless Surgical Lighting Patty for Neurosurgery

Porphyrins in Photodynamic Therapy: A Review

Synthesis of porphyrin-conjugated silica-coated Au nanorods for synergistic photothermal therapy and photodynamic therapy of tumor

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