Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy

Abstract

The present IM spray is an effective and safe preparation for pain relief and can be used as an alternative therapeutic option for oropharyngeal mucositis in cancer patients.

Oral health problems among palliative and terminally ill patients: an integrated systematic review

“…Functional impact include difficulties in swallowing, speaking and eating, food restriction, sense of oral dryness and pain, which resulted in lack of food enjoyment [5,26,28]. Table 4 presents our findings on the management of some oral conditions among palliative patients and their effectiveness [11,15,17,[19][20][21][22][23] Our study revealed that the common management options for xerostomia are drug and medical treatments [15], lubricating lips and mucosa [17], acupuncture [19], and standard oral care which improved dry mouth (in 80% or more) of the patients [11]. For candidiasis, a single-dose fluconazole 150 mg via mouth was found to be very effective as the symptoms decreased significantly (P < 0.001) in most patients [20], and local antifungal treatments were reported to be efficacious in 78.1% of the patients [23].…”

“…Studies reporting on oral conditions among palliative patients are summarized in Table 1. Of the included studies, 16 were quantitative studies [5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24], and 3 were qualitative studies [25][26][27] (Table 2).…”

“…A substantial improvement of dysphagia was also observed after fifth treatment of acupuncture [19], however, its management using step-based pharmacological intervention and topically acting drugs caused worsening of swallowing and soreness of mouth [22]. Also, the management of mucositis using step-based pharmacological intervention and topically-acting drugs did not improve the oral condition [22], however, an indomethacin oral spray has been proven to relieve pain after 25 min [21]. Treatment challenges of oral conditions in palliative patients Table 5 presents our findings on the challenges in treating oral conditions among palliative patients [17,18].…”

“…Apart from the above, it can be seen that among the scientific articles included in the literature review, two papers are concerning head and neck cancer patients [21], which may be more significant on the patient's oral well-being conditions, both for the localization of the tumor and the regional radiotherapy. Therefore, future reviews can focus on patients with specific types of cancer and their oral conditions.…”

Preparation and Evaluation of Rebamipide Colloidal Nanoparticles Obtained by Cogrinding in Ternary Ground Mixtures

“…Currently, indomethacin, which has an analgesic effect, or allopurinol and rebamipide (RB), which have a free radical scavenging effect, are administered to treat stomatitis caused by chemotherapy and radiotherapy [8,[11][12][13][14][15][16][17][18][19]. Allopurinol has a good treatment effect on stomatitis; however, it interacts with fluorouracil, which decreases its anticancer effect, and it has been reported that there are restrictions to its administration [20,21].…”