This chapter reviews the role of cloud computing in global supply chain, thus describing the theoretical and practical concepts of cloud computing and supply chain management (SCM); the significance of cloud computing in global supply chain; the overview of electronic supply chain management (e-SCM); and the organizational information processing theory within global supply chain. The utilization of cloud computing is necessary for modern organizations that seek to serve suppliers and customers, increase business performance, strengthen competitiveness, and achieve continuous success in global business. Therefore, it is essential for modern organizations to examine their cloud computing applications, develop a strategic plan to regularly check their practical advancements, and immediately respond to the cloud computing needs of customers in global supply chain. Applying cloud computing in global supply chain will extremely improve organizational performance and reach business goals in the digital age.