Assessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosus

Avcı, Ahmet; Demir, Kenan; Altunkeser, Bülent Behlül; Yılmaz, Sema; Yılmaz, Ahmet; Erseçgin, Ahmet; Demir, Tarık

doi:10.1111/anec.12145

Cited by 10 publications

(8 citation statements)

References 34 publications

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“…Studies performed to date have demonstrated increased rates of Tp-e interval and Tp-e/QT in autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis, exhibiting an intense systemic inflammation response. In addition, this increase was detected to be correlated with inflammatory parameters [35–37]. Some authors underlined the fact that this electrical abnormality could be a predictor of potential cardiac arrhythmias and cause predisposition.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris

Soylu

İnci

Aksan

et al. 2016

aoms

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IntroductionThe arrhythmia potential has not been investigated adequately in psoriatic patients. In this study, we assessed the ventricular repolarization dispersion, using the Tp-e interval and the Tp-e/QT ratio, and investigated the association with inflammation.Material and methodsSeventy-one psoriasis vulgaris patients and 70 age- and gender-matched healthy individuals were enrolled in the study. The severity of the disease was calculated using Psoriasis Area and Severity Index scoring. The QTd was defined as the difference between the maximum and minimum QT intervals. The Tp-e interval was defined as the interval from the peak of the T wave to the end of the T wave. The Tp-e interval was corrected for heart rate. The Tp-e/QT ratio was calculated using these measurements.ResultsThere were no significant differences between the groups with respect to basal clinical and laboratory characteristics (p > 0.05). The Tp-e interval, the corrected Tp-e interval (cTp-e) and the Tp-e/QT ratio were also significantly higher in psoriasis patients compared to the control group (78.5 ±8.0 ms vs. 71.4 ±7.6 ms, p < 0.001, 86.3 ±13.2 ms vs. 77.6 ±9.0 ms, p < 0.001 and 0.21 ±0.02 vs. 0.19 ±0.02, p < 0.001 respectively). A significant correlation was detected between the cTp-e time and the Tp-e/QT ratio and the PASI score in the group of psoriatic patients (r = 0.51, p < 0.001; r = 0.59, p < 0.001, respectively).ConclusionsIn our study, we detected a significant increase in the Tp-e interval and the Tp-e/QT ratio in patients with psoriasis vulgaris. The Tp-e interval and the Tp-e/QT ratio may be predictors for ventricular arrhythmias in patients with psoriasis vulgaris.

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Section: Discussionmentioning

confidence: 99%

Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris

Soylu

İnci

Aksan

et al. 2016

aoms

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“…Tpe interval in precordial leads, its dispersion and its ratio with QT in V5 have been suggested to provide an indirect and non‐invasive assessment of repolarisation heterogeneity, and they have been evaluated in many cardiac and systemic diseases such as Brugada syndrome, long and short QT syndrome, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, coronary heart disease, heart failure, hypertension, diabetes mellitus, systemic lupus erythematosus and ankylosing spondylitis …”

Section: Introductionmentioning

confidence: 99%

Age- and sex-based reference ranges for non-invasive ventricular repolarisation parameters

et al. 2017

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“…It was reported that the Tp-Te interval was prolonged in patients with rheumatoid arthritis and systemic lupus erythematosus. 32 , 37 In another study, Akcay et al 6 reported that the Tp-Te interval was increased in FMF patients. Similar to that study, we found that the Tp-Te interval was statistically significantly prolonged in FMF patients.…”

Section: Discussionmentioning

confidence: 98%

“… 35 , 36 Previous studies have shown that QTd was significantly higher in some inflammatory diseases. 32 , 37 …”

Section: Discussionmentioning

confidence: 99%

Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Karaman¹,

Karayakalı²,

Erken³

et al. 2017

CVJA

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SummaryBackground:Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/ QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF.Methods:This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram.Results:In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval.Conclusions:Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.

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Assessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosus

Abstract: Our study revealed that QTd, cQTd, Tp-e interval and Tp-e/QT ratio increased in patients with SLE. Also, Tp-e interval and Tp-e/QT were positively correlated with disease duration.

Cited by 10 publications

References 34 publications

Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris

Evaluation of inhomogeneities of repolarization in patients with psoriasis vulgaris

Age- and sex-based reference ranges for non-invasive ventricular repolarisation parameters

Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

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