Assessment of interleukin‐1β, interleukin‐6, and tumor necrosis factor‐Α levels in the peri‐implant sulcular fluid among waterpipe (narghile) smokers and never‐smokers with peri‐implantitis

Abduljabbar, Tariq; Akram, Zohaib; Vohra, Fahim; Warnakulasuriya, Saman; Javed, Fawad

doi:10.1111/cid.12557

Cited by 52 publications

(63 citation statements)

References 37 publications

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“…Numerous studies have investigated the effects of cigarette smoking on peri‐implant health and have reported significantly compromised peri‐implant parameters as compared with non‐smokers (NS) . These results have been confirmed by clinical laboratory investigations and have shown significantly high levels of proinflammatory cytokines in the peri‐implant sulcular fluid (PISF) of cigarette smokers (CS) as compared with NS …”

Section: Introductionmentioning

confidence: 85%

Proinflammatory cytokine levels and peri‐implant parameters among cigarette smokers, individuals vaping electronic cigarettes, and non‐smokers

ArRejaie

Al‐Aali

Alrabiah

et al. 2018

Journal of Periodontology

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108

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Background Tobacco smoking compromises the prognosis of dental implant treatment and is associated with increased risk of peri‐implant bone loss and increased implant failure rate. There is a dearth of studies that have compared clinical, radiographic, and immunological peri‐implant parameters among cigarette smokers (CS), individuals vaping e‐cigarettes (e‐cigs), and non‐smokers (NS). This study aimed to compare clinical and radiographic peri‐implant parameters and levels of matrix metalloproteinase (MMP)‐9 and interleukin (IL)‐1β levels among CS, individuals’ vaping e‐cigs, and NS. Methods Thirty‐two CS (group 1), 31 individuals vaping e‐cigs (group 2), and 32 NS (group 3) were included. Demographic‐ and implant‐related data were collected using a structured baseline questionnaire. Peri‐implant plaque index (PI), bleeding on probing (BOP), and probing depth (PD) were recorded and marginal bone loss (MBL) were assessed using standardized digital radiographs. Enzyme‐linked immunosorbent assay was used to assess levels of MMP‐9 and IL‐1β in peri‐implant sulcular fluid. Pearson correlation coefficient was used to analyze for correlations of MMP‐9 and IL‐1β levels with peri‐implant parameters. Results BOP showed significantly higher values in group 3 as compared with groups 1 and 2 (P < 0.01). PI (P < 0.01), PD ≥ 4 mm (P < 0.01), and mean concentrations of MMP‐9 (P < 0.001) and IL‐1β (P < 0.01) were significantly higher in groups 1 and 2 than group 3. MBL was significantly higher in group 1 as compared with group 2 and group 3 (P < 0.01). Significant positive correlations were found between MMP‐9 (P = 0.0198) and IL‐1β (P = 0.0047) levels and MBL in group 1; and a significant positive correlation between IL‐1β and MBL in group 2 (P = 0.0031). Conclusions Peri‐implant health was compromised among CS than vaping individuals and NS. Increased levels of proinflammatory cytokines in CS and vaping individuals may suggest greater peri‐implant inflammatory response.

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Section: Introductionmentioning

confidence: 85%

Proinflammatory cytokine levels and peri‐implant parameters among cigarette smokers, individuals vaping electronic cigarettes, and non‐smokers

ArRejaie

Al‐Aali

Alrabiah

et al. 2018

Journal of Periodontology

Self Cite

108

View full text Add to dashboard Cite

show abstract

“…4,19 In summary, participants were instructed to avoid eating, drinking, and/or smoking at least 1 hour prior to PISF sample collection. 4,19 In summary, participants were instructed to avoid eating, drinking, and/or smoking at least 1 hour prior to PISF sample collection.…”

Section: Collection Of Pisf Samplesmentioning

confidence: 99%

“…One explanation for this is that habitual use of nicotinic products is associated with an increased expression of proinflammatory cytokines such as IL-1β and TNF-α in the PISF, which if left therapeutically uncontrolled may accelerate osteoclastic activity around implants 4. From a clinical point of view, all nicotinic-product users displayed significantly high peri-implant soft tissue inflammatory parameters (PI and PD) compared with nonsmokers.…”

mentioning

confidence: 99%

Comparison of cotinine levels in the peri‐implant sulcular fluid among cigarette and waterpipe smokers, electronic‐cigarette users, and nonsmokers

Alqahtani

Albaqawi‬

et al. 2019

Clin Implant Dent Rel Res

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Background: Assessment of cotinine levels in the peri-implant sulcular fluid (PISF) may serve as a valuable biomarker of peri-implant diseases in nicotine-product users.Purpose: The aim of the present study was to compare cotinine levels in the PISF among cigarette smokers, waterpipe users, electronic-cigarette users, and nonsmokers.Materials and Methods: Cigarette smokers, waterpipe smokers, electronic-cigarette users, and nonsmokers were included. A questionnaire was used to collect information about age, gender, duration of smoking and vaping, family history of smoking, duration of smoking/vaping, and daily frequency of smoking/vaping. Implant-related data including implant dimensions and duration of implants in function were also recorded. In all groups, peri-implant probing depth (PD), bleeding on probing (BoP), and plaque index (PI) were assessed. Using standard techniques, PISF was collected and levels of cotinine in the PISF were measured. Sample-size estimation was performed, and statistical comparisons were done using one-way analysis of variance and Bonferroni post hoc adjustment tests. P values below .05 were categorized as statistically significant.Results: One hundred two male individuals (35 cigarette smokers, 33 waterpipe smokers, 34 electronic-cigarette users, and 35 nonsmokers) were included. Scores of peri-implant PI (P < .05) and PD (P < .05) were significantly higher among cigarette smokers, waterpipe smokers, and electronic-cigarette users compared with nonsmokers.Peri-implant BoP was more often manifested in nonsmokers compared with cigarette smokers (P < .05), waterpipe smokers (P < .05), and electronic-cigarette users (P < .05).The volume of collected PISF was significantly higher among cigarette (P < .05) and

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“…17 Results were calculated using the standard curves created in each assay. 17 Results were calculated using the standard curves created in each assay.…”

Section: Collection Of Peri-implant Sulcular Fluidmentioning

confidence: 99%

Association of advanced glycation end products with peri‐implant inflammation in prediabetes and type 2 diabetes mellitus patients

Alrabiah

Al‐Aali

Al-Sowygh

et al. 2018

Clin Implant Dent Rel Res

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Assessment of interleukin‐1β, interleukin‐6, and tumor necrosis factor‐Α levels in the peri‐implant sulcular fluid among waterpipe (narghile) smokers and never‐smokers with peri‐implantitis

Abstract: WS with peri-implantitis present increased expression of local proinflammatory cytokines in the PISF than never-smokers.

Cited by 52 publications

References 37 publications

Proinflammatory cytokine levels and peri‐implant parameters among cigarette smokers, individuals vaping electronic cigarettes, and non‐smokers

Proinflammatory cytokine levels and peri‐implant parameters among cigarette smokers, individuals vaping electronic cigarettes, and non‐smokers

Comparison of cotinine levels in the peri‐implant sulcular fluid among cigarette and waterpipe smokers, electronic‐cigarette users, and nonsmokers

Association of advanced glycation end products with peri‐implant inflammation in prediabetes and type 2 diabetes mellitus patients

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