Assessment of intima-media complex in carotid, femoral and right subclavian arteries for early investigation of atherosclerosis in HIV-infected patients

Godoi, Emmanuelle Tenório Albuquerque Madruga; Brandt, Carlos Teixeira; Godoi, Jocelene Tenório Albuquerque Madruga; Melo, Heloísa Ramos Lacerda de; Godoi, Juannicelle Tenório Albuquerque Madruga

doi:10.1590/s0100-39842013000600004

Cited by 1 publication

(3 citation statements)

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“…Our findings differ from those of Godoi et al 21,22 on 70 HIV patients and 70 controls, showing no difference between these groups. However, the study involved younger subjects, and included smoking, hypertensive and DM controls, which may have contributed to greater IMT values.…”

Section: Discussioncontrasting

confidence: 99%

“…However, these parameters do not combine both high specificity and high sensitivity, which was corroborated by our study. 16,17,22 …”

Section: Discussionmentioning

confidence: 99%

“…As our study population was composed of patients aged less than 65 years, thickened intima-media was defined as an IMT equal to or higher than 0.8 mm. 17,21,22 The 75 percentile of the study group was also calculated, 15 and the presence of atheromatous plaque was defined as an IMT higher than 1.5 mm. 15 The IMT was also measured in the right common femoral artery (RCFA) and left common femoral artery (LCFA), using the same criteria for IMT and atheromatous plaque definition.…”

Section: Methodsmentioning

confidence: 99%

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Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals

Godoi¹,

Brandt²,

Lacerda³

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundThe prevalence of atherosclerosis is higher in HIV-positive people, who also experience it earlier than the general population.ObjectivesTo assess and compare the prevalence of atherosclerosis evaluated by the intima-media thickness of carotid and femoral arteries, and by the ankle-brachial pressure index (ABPI) in HIV patients treated or not treated with protease inhibitors (PIs) and controls.MethodsEighty HIV+ subjects (40 using PIs and 40 not using PIs) and 65 controls were included in the study. Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. Classical risk factors for atherosclerosis and HIV were compared between the groups by statistical tests. A p ≤ 0.05 was considered significant.ResultsAn IMT > P75 or the presence of plaque was higher in the HIV+ than in the control group (37.5% vs 19%, p = 0.04). Comparative analysis showed a significant difference (p=0.014) in carotid IMT between HIV+ with PIs (0.71 ± 0.28 mm), without PIs 0.63 ± 0.11 mm and, and controls (0.59 ± 0.11 mm). There was no significant difference in femoral IMT between the groups or in ABPI between HIV+ subjects and controls. However, a significant difference (p=0.015) was found between HIV+ patients not treated with PIs (1.17 [1.08 - 1.23]), and controls 1.08 [1.07 - 1.17]).ConclusionIn HIV patients, atherosclerosis is more prevalent and seems to occur earlier with particular characteristics compared with HIV-negative subjects.

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Section: Discussioncontrasting

confidence: 99%

“…However, these parameters do not combine both high specificity and high sensitivity, which was corroborated by our study. 16,17,22 …”

Section: Discussionmentioning

confidence: 99%