Assessment of jawbone trabecular bone structure amongst osteoporotic women by cone‐beam computed tomography: the OSTEOSYR project

Abstract

Objective: To assess the trabecular bone structure of jawbones and the dens (the odontoid process of the second cervical vertebra) amongst osteoporotic and nonosteoporotic women using cone-beam computed tomography (CBCT). Analysis of the dens trabecular bone structure aimed to test the validity of CBCT in such analysis. Methods: Thirty-eight women who went under dual-energy X-ray absorptiometry (DXA) examination were scanned by CBCT. Cuboids from different areas of jawbones and the dens were extracted from each scan. Trabecular thickness (Tb.Th), trabecular separation (Tb.S), bone volume fraction (BV/TV), specific bone surface (BS/TV) and connectivity density were calculated. Student's t-test, Pearson correlation, and logistic regression analysis were used to explore differences in these measures between groups. Results: Jawbone-derived measures showed insignificant differences (P > 0.05) between osteoporotic and non-osteoporotic groups, and weak correlations with femoral neck and lumbar vertebrae T-scores (r ≤ 0.4). Dens-derived measures, however, resulted in the opposite (r = 0.34-0.38 [P value = 0.02-0.036] and r = 0.48-0.61 [P value ≤ 0.003]) and the highest accuracy of osteoporosis prediction: 84.2% and 78.9% respectively. Conclusion: Trabecular bone structure of the mandible and maxilla is not affected in osteoporosis as assessed by CBCT. Dens trabecular bone analysis revealed the opposite, so some trabecular bone measures may be assessed by CBCT, which may aid in predicting osteoporosis.

Detecting the effect of bisphosphonates during osteoporosis treatment on jawbones using multidetector computed tomography: The OSTEOSYR project

“…The RD of the edentulous area was then measured on the sagittal slice (Figure E). In addition, bone histomorphometry of the edentulous areas was performed after trimming the scans to obtain the biggest possible cuboid, as previously described . Briefly, bone cuboids from the edentulous areas were obtained from the MDCT scans using the “trim image (loads trimmed image as new project)” tool of the WhiteFox Imaging software (WhiteFox, de Gotzen S.r.l device, distributed by Satelec‐Acteon Group, Milan, Italy).…”

“…Bone histomorphometric analysis was used as previously described . Bone cuboids from the mental region and posterior to the right and left mental foramen regions were obtained and analyzed following the same procedures mentioned above.…”

Osteoporosis of the Jaws and its Diagnostic Methods: Review of the Literature

“…Estudios que evaluaron la estructura ósea trabecular de los maxilares en TCHC, no revelaron grandes cambios que podrían identificarse como osteoporosis, arrojando datos más significativos de osteoporosis al analizar y evaluar el trabeculado óseo de la 2da vértebra cervical a nivel del odontoides (50), es así que mediante la tomografía y la resonancia magnética, se podría evaluar la estructura del hueso trabecular, midiendo el volumen, el espaciado y la conectividad, los estudios son prometedores; pero los costos y la complejidad de estos métodos, serían una limitante del uso diario en la práctica clínica (50,51).…”

Utilização da tomografia computadorizada de feixe cônico na obtenção dos índices radiomorfométricos em mulheres na pré e pós menopausa

“…A perda óssea ocorre com a idade em homens e mulheres (osteoporose relacionada com a idade), mas nas mulheres a taxa de perda óssea aumenta quando há a menopausa (osteoporose pós-menopausa) (Horner;Devlin, 1998), sendo a deficiência de estrogênio o principal fator contribuinte para a perda óssea nesse estágio (Maeda;Lazaretti-Castro, 2014). Por esta razão, escolhemos estudar a população feminina com idade acima de quarenta anos e incluímos no estudo um total de 75 exames TCFC de pacientes do gênero feminino, assim como nos estudos prévios (Klemetti et al, 1994;Ledgerton et al, 1999;Mahl et al, 2008;Nackaerts et al, 2008;Koh;Kim, 2011;Valério et al, 2013;Gomes et al, 2014;Diniz-Freitas et al, 2014e Barngkgei et al, 2015a -López et al, 2011;Calciolari et al, 2015). A vantagem destes índices é que os cirurgiões dentistas podem aplicá-los como ferramentas de baixo custo para detectar sinais precoces de baixa densidade óssea ou osteoporose (Calciolari et al, 2015), uma vez que, estes profissionais são comumente consultados por um grande segmento da população (Barngkgei et al, 2015a;Barngkgei et al, 2015b).…”

“…E muitas vezes os autores não colocam todas as informações do protocolo de aquisição das imagens, dificultando a comparação dos estudos. O número de estudos que avaliaram a TCFC e osteoporose sem abordar HU é muito pequena (Koh;Kim, 2011;Gomes et al, 2014;Diniz-Freitas et al, 2014;Barngkgei et al, 2015a).…”