Assessment of left ventricular systolic and diastolic function by tissue Doppler analysis in patients with hypertension with or without hyperuricemia

Tavıl, Yusuf; Kaya, Mehmet; Şen, Nihat; Taçoy, Gülten; Okyay, Kaan; Yazici, Hüseyin; Yalçın, Mehmet Rıdvan; Çengel, Atiye

doi:10.1097/mbp.0b013e3282faa732

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…Obviously LV MPI was damaged in groups with AH with and without hyperuricemia compared to controls (0.53 ± 0.07, 0.48 ± 0.09, and 0.39 ± 0.07, respectively, p < 0.001). However, it was also observed that the value of LV MPI in patients with AH and hyperuricemia was significantly higher than in patients with AH without hyperuricemia [34]. In our opinion, hyperuricemia can play an important role in the development of diastolic dysfunction in patients with CKD.…”

Section: Discussionmentioning

confidence: 73%

“…They have also found that hyperuricemia can be a marker for subsequent LV dysfunction. The relationship between hyperuricemia and LV dysfunction was evaluated by Tavil Y et al [34]. In this study, the authors assessed the LV myocardial performance index (LV MPI) in tissue Doppler imaging in patients with arterial hypertension (AH) with and without hyperuricemia and a group of healthy control volunteers.…”

Section: Discussionmentioning

confidence: 99%

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Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Gromadziński¹,

Januszko‐Giergielewicz

Pruszczyk

2015

Adv Clin Exp Med

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Background. It has been reported that elevated serum uric acid (UA) levels is an independent factor of poor prognosis in patients with chronic heart failure and chronic kidney disease (CKD). Objectives. In our study, we assessed the potential impact of hyperuricemia on left ventricular (LV) diastolic dysfunction (DD) in patient with CKD. Material and Methods. The study group consisted of 50 patients with CKD, stages 2-5. Standard echocardiography and tissue Doppler imaging (TDI) were performed. The levels of UA and N-terminal prohormone brain natriuretic peptide (NT-proBNP) were determined. Patients were divided into two groups according to the results of peak mitral annular early diastolic velocity (EmLV): group with LV diastolic dysfunction (EmLV < 8 cm/s) DD (+) and group with normal LV diastolic function DD (-), when EmLV ≥ 8 cm/s. Results. Patients DD (+) group, as compared to DD (-) patients were characterized by significantly higher serum UA levels [6.7 (4.4-14.3) mg/dL vs 5.8 (1.9-8.9) mg/dL, p = 0.004] respectively. The area under the receiver operating characteristic (ROC) curve was of serum UA levels for the detection of LV diastolic dysfunction was 0.734, 95% confidence interval (CI) 0.590-0.849, p = 0.001, whereas ROC derived UA value of > 6.0 mg/dL was characterized by a sensitivity of 76.9% and specificity of 62.5% for diagnosing LV diastolic dysfunction. The independent variable predicting LV diastolic dysfunction as measured by a multivariate logistic regression analysis was UA level > 6.0 mg/dL with odds ratio (OR) = 14.3 (95% CI 2.0-103.2), p = 0.006. Conclusions. Hyperuricemia is an independent predictive factor for LV diastolic dysfunction in patients with CKD (Adv Clin Exp Med 2015, 24, 1, 47-54).

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Gromadziński¹,

Januszko‐Giergielewicz

Pruszczyk

2015

Adv Clin Exp Med

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“…15 Hyperuricemia is also a marker of impaired oxidative metabolism, which may correlate with left ventricular systolic and diastolic dysfunction in patients with chronic heart failure. [16][17][18][19] Heart failure is a state of chronic deterioration of oxidative mechanisms due to enhanced oxidative stress and upregulated oxidant-producing enzymes, in particular xanthine oxidase. This impaired oxidative metabolism may be implicated in the development of cardiac hypertrophy, myocardial fibrosis, left ventricular remodeling, and contractility impairment.…”

Section: Discussionmentioning

confidence: 99%

Significant Correlation between Left Ventricular Systolic and Diastolic Dysfunction and Decreased Glomerular Filtration Rate

Hsieh

Wang

et al. 2011

Renal Failure

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Cardiac dysfunction portends a poor prognosis in renal failure and vice versa. Functional abnormalities of heart in patients with renal insufficiency were frequently noted. The aim of this study is to assess the relationship between left ventricular systolic and diastolic function and renal function in patients with various degrees of renal function. This cross-sectional study included 167 patients from our Outpatient Department of Internal Medicine. Left ventricular systolic and diastolic functions were assessed by echocardiography. Clinical and echocardiographic parameters were compared and analyzed. The prevalence of left ventricular ejection fraction (LVEF) <50% was 31.7% and the average value of the ratio of peak early transmitral filling wave velocity (E) to early diastolic velocity of lateral mitral annulus (Ea) was 11.4 ± 6.2. After the multivariate analysis, low systolic blood pressure, rapid heart rate, low albumin, and low estimated glomerular filtration rate (eGFR) (odds ratio = 0.957; 95% confidence interval = 0.929-0.986; p = 0.004) levels were associated with LVEF < 50%. Besides, old age, low albumin, low eGFR (β = −0.172; p = 0.043), and high uric acid levels were associated with high E/Ea. Our findings show a significant correlation between LVEF < 50% and high E/Ea and decreased eGFR.Keywords: left ventricular ejection fraction, the ratio of peak early transmitral filling wave velocity (E) to early diastolic velocity of lateral mitral annulus (Ea), estimated glomerular filtration rate

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“…In the present study a positive correlation was observed between UA and EF, (p<0.05 in the presence of obesity). Tavil et al used issue Doppler imaging for the evaluation of myocardial performance index (MPI) (30). MPI in patients with arterial hypertension and hyperuricemia was significantly higher than in hypertensive patients without hyperuricemia.…”

Section: Discussion:-mentioning

confidence: 99%

Role of Uric Acid in Cardiac Changes in Overweight and Obese Children

Schusterova¹,

Banovcinova²,

Takacova³

et al. 2019

IJAR

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Background: High serum uric acid (UA) levels appear to contribute to an increase in blood pressure (BP) in obese adolescents and may amplify the cardiac volume overload effects of obesity with pressure overload. Association between UA and ejection fraction (EF) is still controversial. Some studies showed negatively correlations, others did not found any correlation. So far, no data have been published regarding the influence of UA levels on structural and functional changes of the LV in children with obesity. Objective: The aim of our study was to assess the influence of UA levels on LV structure and function in overweight/obese children. Study groups and methods: In 25 (mean age 13.0 ± 2.3) overweight/obese subjects and 24 lean controls, BP, fasting plasma glucose, insulin, and UA were measured. LV structural and functional parameters were measured by echocardiography. Results: In overweight/obese children UA correlates with LV diastolic volumes and LV systolic function but not with LVM whereas in children without obesity UA correlates with LVM and LV diastolic function. Conclusion: The present study demonstrates a positive correlation of UA with EF and left atrium and LV volume in volume overload due to obesity in children. These conclusions require further investigation.

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Assessment of left ventricular systolic and diastolic function by tissue Doppler analysis in patients with hypertension with or without hyperuricemia

Cited by 12 publications

References 21 publications

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Hyperuricemia is an Independent Predictive Factor for Left Ventricular Diastolic Dysfunction in Patients with Chronic Kidney Disease

Significant Correlation between Left Ventricular Systolic and Diastolic Dysfunction and Decreased Glomerular Filtration Rate

Role of Uric Acid in Cardiac Changes in Overweight and Obese Children

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