Assessment of macular function of glaucomatous eyes by multifocal electroretinograms

Hori, Nobuhide; Komori, Shinya; Yamada, Hiroki; Sawada, Akira; Nomura, Yasunori; Mochizuki, Kiyofumi; Yamamoto, Tetsuya

doi:10.1007/s10633-012-9351-0

Cited by 12 publications

(17 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nasal-temporal asymmetry of the mfERG scans is affected in glaucomatous eyes [11,12]. We previously reported significant differences existed in the N/T of the first slice of the second-order kernel of the mfERG scans in the central 5° between normal and NTG eyes and found significant correlations between the N/T and the MT obtained with the HFA 30 − 2 and 10 − 2 results [11,14], findings which are in agreement with the current study. The N/T was significantly different between normal subjects and glaucoma patients (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Both glaucoma patients and normal subjects underwent mfERG. We used the Visual Evoked Response Imaging System Science (VERIS) 5.1.10× (Electro-Diagnostic Imaging, Milpitas, CA, USA) to record mERG scans according to a published method [11,12,14]. After pupils were dilated to at least 8 mm in diameter with Mydrin-P®, we placed a bipolar contact lens electrode (Mayo, Inazawa, Japan) on the anesthetized (oxybuprocaine hydrochloride, Benoxil®; Santen Pharmaceutical, Osaka, Japan) cornea.…”

Section: Mferg Scansmentioning

confidence: 99%

“…There are several reports available outlining direct comparisons among visual sensitivities determined by standard automated perimetry (SAP), structural parameters of the inner retina obtained by optical coherence tomography (OCT), and the amplitude of the PhNR/B or the N/T [4,5,[13][14][15], but no reports especially conducting comparisons between N/T and the PhNR/B of mfERG scans (mfPhNR/B) in the same glaucoma patient have been published.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Tanaka

Ishida

Ozawa

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: The association between the structure of the macular region and its function as measured by multifocal electroretinography (mfERG) and the mean thresholds (MT) of the visual field (VF) is not well-understood. Methods: The macular retinal nerve fiber layer (mRNFL) and the ganglion cell and inner plexiform layer (GCIPL) in six regions were measured by optical coherence tomography (OCT). For functional assessment, MT and mfERG scans with parameters of the second-order kernel responses within the central 5°, nasal to temporal amplitudes ratio (N/T), and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Forty-one glaucoma patients underwent OCT, mfERG, and MT measurement and 55 healthy subjects underwent mfERG. Results: The mfPhNR/B was significantly smaller ( P < 0.01) and the N/T was significantly larger ( P < 0.01) in glaucoma patients than in normal subjects. In glaucoma patients, the N/T is significantly correlated with the thickness of inferior and inferotemporal GCIPL ( r = -0.317 and -0.360, respectively) and MT of corresponding VF areas ( r = -0.330 and -0.334, respectively) (all P values < 0.05). The mfPhNR/B was significantly correlated with the thickness of mRNFL in the central area ( r = 0.365, P = 0.02) and with the MT of all corresponding VF areas ( r rages between 0.330 and 0.460, all P values < 0.04), except for the inferotemporal area. However, correlation was not observed between the N/T and the mfPhNR/B in any location. Conclusions: Significant differences exist between glaucoma and healthy participants in the N/T and mfPhNR/B. Correlations were observed between two mfERG parameters and OCT parameters or MT in glaucoma patients. Further research should seek to demonstrate whether the N/T and the mfPhNR/B should be applied in a complementary fashion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Mferg Scansmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Tanaka

Ishida

Ozawa

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…All glaucoma patients underwent mfERG. We used the Visual Evoked Response Imaging System Science (VERIS) 5.1.10× (Electro-Diagnostic Imaging, Milpitas, CA, USA) to record mERG scans according to a published method [11,12,14]. After pupils were dilated to at least 8 mm in diameter with Mydrin-P ® , we placed a bipolar contact lens electrode (Mayo, Inazawa, Japan) on the anesthetized (oxybuprocaine hydrochloride, Benoxil ® ; Santen Pharmaceutical, Osaka, Japan) cornea.…”

Section: Mferg Scansmentioning

confidence: 99%

“…We studied the amplitudes of the rst positive peak, P1 ( Figure 2b). The P1 amplitudes of the rst slice of the second-order kernel responses were measured according to a published method [11,12,14].…”

Section: P1 Component Of the Rst Slice Of Second-order Kernels Of mentioning

confidence: 99%

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Tanaka

Ishida

Ozawa

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet. Methods: For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of forty-four glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated. Results: The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30-2 and VF 10-2 was -7.00 and -6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = -7.916 and -7.857, and MT vs N/T ; coefficient = -4.302 and -4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012). Conclusions: The N/T is better parameter than PhNR/B for the assessment of glaucomatous eyes in the current study’s measurement conditions. A future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.

show abstract

Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma

Ledolter

Monhart²,

Schötzau

et al. 2017

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

PurposeTo improve structure-function analysis in primary open-angle glaucoma (POAG) by including the two-global flash multifocal electroretinogram (2F–mfERG) and macular ganglion cell layer segmentation.MethodsTwenty-five glaucoma patients (six pre-perimetric (PPG), 19 POAG) and 16 controls underwent 2F–mfERG, optical coherence tomography (OCT), and standard automated perimetry (SAP). For 2F–mfERG, the root mean square was calculated for the focal flash response at 15–45 ms (DC) and the global flash responses at 45–75 ms (IC1) and 75–105 ms (IC2). For OCT, macular total thickness (mT) and ganglion cell-inner plexiform layer (GCIPL) thickness were analysed. Values from the central 10° and 15° of 2F-mfERG were compared to the corresponding areas from OCT and visual field.ResultsBoth PPG and POAG had significantly lower mfERG responses in the central 10° and 15° than the control group. Of the glaucoma patients, 30.7% (three PPG, five POAG) showed central mfERG and GCIPL reduction without a SAP defect in the central 15 degrees. Four patients had a central SAP defect associated with a reduced GCIPL without any detectable dysfunction on mfERG. MfERG DC and IC2 were larger with increased mT (p ≤ 0.02), but GCIPL only related positively to IC2 (p = 0.027). SAP sensitivity also increased with thicker mT but not with GCIPL (p < 0.03 and p = 0.35). DC, IC2, and GCIPL could best differentiate glaucoma from control (AUC values: 0.897, 0.903, and 0.905).ConclusionsStructure function analysis in glaucoma can be improved when the GCIPL thickness as well as the 2F–mfERG is included as these measures complement information obtained by SAP.

show abstract

Assessment of macular function of glaucomatous eyes by multifocal electroretinograms

Abstract: Functional glaucomatous changes determined by mfERGs and perimetry are significantly correlated with the morphological changes determined by OCT.

Cited by 12 publications

References 45 publications

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma

Contact Info

Product

Resources

About