Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

Açmaz, Gökhan; Ataş, Mustafa; Gülhan, Ahmet; Acmaz, Banu; Ataş, Fatma; Aksoy, Hüseyin; Zararsız, Gökmen; Gökçe, Gökçen

doi:10.12659/msm.893221

Cited by 19 publications

(22 citation statements)

References 26 publications

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“…There is limited data on this issue and to the best of our knowledge this is the first study to compare CT in pregnant women with type 1 and type 2 DM. Acmaz et al 40 reported that CT was significantly thicker in healthy pregnant women and women with GDM in comparison with non-pregnant women. However, there was no significant difference between the GDM group and the healthy pregnant women group.…”

Section: Discussionmentioning

confidence: 99%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

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PurposeTo analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography.Patients and methodsThis cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy.ResultsThe comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements.ConclusionPregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM.

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Section: Discussionmentioning

confidence: 99%

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Benfica¹,

Zanella²,

Farias³

et al. 2018

OPTH

View full text Add to dashboard Cite

show abstract

“…In another similar study, Acmaz et al found that RNFL thickness, especially the nasal part, was significantly decreased in pregnant women with gestational diabetes more than in the healthy pregnant women [ 32 ]. They speculated in a similar way to ours that deterioration of the blood supply to nerves may lead to thinning of RNFL in pregnant women with gestational diabetes.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, and Choroidal Thickness

et al. 2017

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BackgroundThe aim of this study was to evaluate the effect of oral contraceptive pills (OCP) on the macula, the retinal nerve fiber layer (RNFL), and choroidal thickness (CT).Material/MethodsA total of 24 healthy women taking monophasic OCP (3 mg drospirenone and 0.03 mg ethinylestradiol) for contraception only for at least one year were compared with a control group of 24 healthy women who were not taking an OCP. Optical coherence tomography (OCT) was used to evaluate the posterior ocular segments, and measurements were taken in the follicular phase (day 3) of the cycle in all women.ResultsNo disparity in terms of age and body mass index between the groups was observed (p=0.436, p=0.538, respectively). In comparison of the macular region and CT between groups, we found that all variables except foveal center thickness and CT were significantly thinner in the OCP group. Nasal and temporal inferior parts of the RNFL and average RNFL were significantly slimmer in the study group versus the control group (p=0.013, p=0.018, and p<0.001, respectively).ConclusionsOCP resulted in several structural changes in the posterior ocular segment. Thus, women using OCP for more than one year may have some eye problems. Therefore, it OCT should be performed for these women. Further clinical trials researching long-period effect of OCP on the eyes are needed.

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“…Choroidal thickness can be influenced by major factors such as age, refractive error and axial length (AL), with increasing age, AL and decreasing refractive diopter being associated with a reduction of choroidal thickness [ 23 ]. Previous authors have measured choroidal thickness during pregnancy, with conflicting results [ 16 , 24 – 32 ]. Different methodology may justify these different results.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of choroidal thickness in third trimester pregnant women

et al. 2018

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BackgroundThe impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregnant women using spectral-domain optical coherence tomography (OCT).MethodsThis cross-sectional study included 122 eyes of 61 women, divided into two groups: 27 healthy pregnant women in the third trimester and 34 age-matched healthy non-pregnant women. Choroidal thickness was measured using Enhanced Depth Imaging OCT at ten different locations: at the fovea and every 500 µm from the fovea up to 2500 µm temporally and up to 2000 µm nasally.ResultsThere were no significant differences in the ten measurements of choroidal thickness comparing both groups. Mean subfoveal choroidal thickness was 304.1 + 9.6 µm in the control group and 318.1 + 15.6 µm in the pregnant women group (p = 0.446). There was also no statistically significant association between gestational age and choroidal thickness measurements in the healthy pregnant women group.ConclusionsOur study showed no statistically difference in choroidal thickness between healthy non-pregnant women and healthy pregnant women in the third trimester.

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Assessment of Macular Peripapillary Nerve Fiber Layer and Choroidal Thickness Changes in Pregnant Women with Gestational Diabetes Mellitus, Healthy Pregnant Women, and Healthy Non-Pregnant Women

Cited by 19 publications

References 26 publications

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

The Effect of Oral Contraceptive Pills on the Macula, the Retinal Nerve Fiber Layer, and Choroidal Thickness

Comparative analysis of choroidal thickness in third trimester pregnant women

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