Assessment of male serum anti-Mullerian hormone as a marker of spermatogenesis and ICSI outcome

El-Halawaty, Samir; Azab, Hamdy; Said, Tamer M.; Amer, Medhat; Kamal, Manal; Hesham, Al-Inany

doi:10.3109/09513590.2010.495433

Cited by 23 publications

(22 citation statements)

References 16 publications

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“…Al-Qahtani et al [32] and Appasamy et al [33] reported that serum AMH concentration in infertile males was significantly lower than that of normal males. However, some studies have reported no statistically significant differences in serum AMH levels between males with oligospermia and those with normal sperm concentrations, or between infertile men and fertile men [34,35] . We explored the correlation between serum levels of sex hormones and kisspeptin, and sperm concentration in infertile and fertile men to determine if the serum kisspeptin level could be used as an indicator of male spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum Kisspeptin and Spermatogenic Function in Men

Liu

Han

et al. 2019

Preprint

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Kisspeptin along with its receptor GPR54 or KISS1R regulates the secretion of hormones involved in the hypothalamic-pituitary-testicular axis, which is one of the contributing factors of adolescent spermatogenesis. This study aimed to investigate the correlation between serum kisspeptin concentration and spermatogenic function, and its predictive value in azoospermia. We retrospectively analyzed data of 196 males who visited the Reproductive Medicine Center of Qilu Hospital of Shandong University from June-November 2018; 20 were fertile and 176 were infertile. The following semen tests were performed: serum kisspeptin level by enzyme immunoassay; and levels of follicle-stimulating and luteinizing hormones, and testosterone by chemiluminescence assay. Percutaneous testicular sperm aspiration was performed on males with azoospermia. Subjects were divided into 5 groups: azoospermia (group A: 22 men with obstructive azoospermia; group B: 54 men with non-obstructive azoospermia), oligospermia (group C: 56 men), infertility with normal semen concentration (group D: 44 men), and fertility with normal semen concentration (group E: 20 men). Kisspeptin levels in the fertile group were higher than those in the infertile group. Levels of serum hormones, testosterone, and kisspeptin correlated with sperm concentration, with the strongest correlation between kisspeptin and sperm concentration (correlation coefficient=0.692). Levels of kisspeptin in obstructive and non-obstructive azoospermia groups were analyzed using Receiver-Operating-Curve analysis. A serum kisspeptin level ≥80.655 was classified as obstructive azoospermia; otherwise, the classification was nonobstructive azoospermia. Serum kisspeptin levels in the fertility group were significantly higher than that in the infertility group; this suggests kisspeptin may be associated with male fertility. Moreover, kisspeptin had a stronger correlation with sperm concentration than the hormones. A serum kisspeptin level of 80.655 can be used to differentiate obstructive and non-obstructive azoospermia.

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Section: Discussionmentioning

confidence: 99%

Correlation between Serum Kisspeptin and Spermatogenic Function in Men

Liu

Han

et al. 2019

Preprint

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“…On the contrary, according to other authors, serum AMH levels were not indicative of spermatogenesis and could not differentiate between fertile and infertile males (15) and between azoospermic, oligospermic and normospermic men (15,26). It was also reported that serum AMH levels neither predicted the presence of sperm in the testis of azoospermic men (11) nor differentiated between NOA with and without spermatozoa in testicular samples (27, 28).…”

Section: Discussionmentioning

confidence: 89%

“…Studies on the potential role of AMH in male infertility have also produced conflicting results regarding the value of serum AMH to differentiate between fertile and infertile males (12,(15)(16)26). This controversy is related to the heterogeneity of the studied populations and ranging of sperm concentration from subtle abnormalities to severe oligozoospermia and NOA.…”

Section: Discussionmentioning

confidence: 98%

Serum Inhibin B And Anti-Mullerian Hormone Assessment in Infertile Men with and Without Non-Obstructive Azoospermia

Bensalem¹

2013

Acta Endo (Buc)

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Context. Inhibin B could be a good marker in predicting spermatogenetic activities and in discriminating men with spermatogenesis impairment, especially azoospermia and it would be considered as a current clinical tool in the future.Objective. This study aimed to investigate the clinical value of serum Inhibin B and AMH levels in subfertile men particularly in those with non-obstructive azoospermia (NOA). We conducted a prospective study to assess the role of inhibin B in the evaluation of male factor infertility.Patients and Methods. Thirty fertile men and three groups of infertile patients (n=91): normozoospermia (n = 40), oligozoospermia (n = 19) and NOA (n = 32), from Faculty of Medicine (Sfax, Tunisia) were investigated. Serum levels were measured by ELISA and by ELFA (FSH).Results. Inhibin B and AMH levels were significantly lower in NOA patients than in normozoospermic ones (72.6±76.8 pg/mL vs. 242.4± 124.7 pg/mL; p<0.001 and 3.7±2.9 ng/mL vs. 5.3±2.3 ng/mL; p<0.001). Only Inhibin B levels were significantly lower in NOA than in oligozoospermic (72.6±76.8 pg/mL vs. 141.3± 81.9 pg/mL; p<0.001) and were negatively correlated with FSH concentrations (r = -0.56, p = 0.001). But both Inhibin B and AMH were positively correlated with sperm count (r = 0.44, p < 0.0001and r = 0.26, p = 0.03 respectively).Conclusions. We conclude that our results support the literature data showing that serum Inhibin B level is strongly correlated with sperm count and suggesting that it could be a good marker in discriminating men with spermatogenesis impairment, especially NOA.

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“…Secondly, difference in BMI between two groups existed. BMI is inverse related with ovarian reserve, and usually but not always, in patients with PCOS[ 16 – 19 ]. Therefore, we performed further analysis using ANCOVA to adjust BMI.…”

Section: Discussionmentioning

confidence: 99%

Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone

et al. 2016

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ObjectiveTo explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve.DesignCase-control study.PatientsA total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography (HSG) and 217 women with normal fallopians were recruited.MeasurementsSerum anti-Mullerian hormone (AMH), basic follicle-stimulating hormone (FSH), luteining hormone (LH), estradiol (E2), and testosterone (T) were measured; and antral follicle counts (AFCs) were recorded.ResultsSignificantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group [2.62 (2.95) ng/ml vs. 3.37 (3.11) ng/ml, P = 0.03], and the difference remained after adjustment of BMI (Padjust = 0.04). However, no statistical difference was found in the levels of FSH [7.00 (2.16) IU/L vs. 6.74 (2.30) IU/L], LH [4.18 (1.52) IU/L vs. 4.63 (2.52) IU/L], E2 [35.95 (20.40) pg/ml vs. 34.90 (17.85) pg/ml], T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl], and AFC [6.00 (4.00) vs. 7.00 (4.00)] between two groups (p>0.05).ConclusionsWomen with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.

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Assessment of male serum anti-Mullerian hormone as a marker of spermatogenesis and ICSI outcome

Abstract: Male serum AMH levels are not indicative of spermatogenesis and cannot differentiate between fertile and infertile males. Serum AMH levels were not predictive of ICSI outcome as well.

Cited by 23 publications

References 16 publications

Correlation between Serum Kisspeptin and Spermatogenic Function in Men

Correlation between Serum Kisspeptin and Spermatogenic Function in Men

Serum Inhibin B And Anti-Mullerian Hormone Assessment in Infertile Men with and Without Non-Obstructive Azoospermia

Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone

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