Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives

Abstract

Objective: Patients with resistant hypertension are at increased risk for cardiovascular events. Mean platelet volume (MPV) is an accepted biomarker of platelet activation and considered as a risk factor for cardiovascular disease. The aim of this study was to determine whether MPV levels are higher in resistant hypertensive (RHTN) patients than in controlled hypertensive (CHTN) patients and healthy normotensive controls. Materials and Methods Results:The mean platelet volume levels were significantly higher in RHTN group than in the CHTN and normotensive groups (p<0.001). In correlation analysis office systolic and diastolic blood pressure was positively correlated with MPV. Conclusion:Our study demonstrated that MPV, as an important indicator of platelet activation, was statistically higher in RHTN patients than in CHTN and in normotensive subjects. Elevated MPV levels may help to determine a high risk group for atherosclerosis in RHTN patients. Bulgular: Dirençli hipertansif grupta ortalama trombosit hacmi kontrollü hipertansif ve normotansif gruba göre istatistiksel olarak anlamlı olarak yüksek saptanmıştır (p<0,001). Korelasyon analizinde ofis sistolik ve diastoliktansiyonları ortalama trombosit hacmiyle pozitif korelasyon göstermekteydi. KeywordsSonuç: Çalışmamızda trombosit aktivasyonunun önemli belirteci olan ortalama trombosit hacmi dirençli hipertansif hastalarda diğer gruplara gore anlamlı olarak yüksek saptanmıştır. Artmış ortalama trombosit hacminin dirençli hipertansif hastalarda atheroskleroz açısından yük-sek riskli olanları değerlendirmede kullanılabileceği düşünülmektedir.Anahtar Kelimeler: Dirençli hipertansion, ortalama trombosit hacmi, kontrollü hipertansiyon

Association between mean platelet volume and hypertension incidence

“…However, the role of platelet activation in cardiovascular events has led us to speculate that it may be associated with hypertension. In fact, previous studies have found elevated MPV values in resistant hypertension 6 and non-dipper hypertension. 7 However, whether an elevated MPV can independently predict future risk for hypertension has not been noted in the literature.…”

Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat

“…Jalur NO memliki interaksi sinergistik dengan pembentukan/degradasi nukleotida siklik dan fosforilasi protein pada trombosit dan sel otot polos, yang mengatur fungsi kardiovaskular (tonus vaskular, inhibisi agregasi trombosit serta adhesi leukosit, dan pencegahan proliferasi sel otot polos). [8][9][10] Dalam beberapa tahun terakhir, neutrofilia dan lymphocytopenia relatif terbukti menjadi prediktor independen kematian pada pasien dengan gagal jantung akut. Selain itu, rasio neutrofil-ke-limfosit (NLR) diperkenalkan sebagai penanda potensial untuk menentukan inflamasi pada gangguan jantung dan nonjantung.…”

An association of platelet indices with blood pressure in Beijing adults

“…[19–23] Moreover, the use of antiplatelet management therapies in the high blood pressure, the platelets play a pivotal role in the pathogenesis of hypertension. [24–27] Thus, assessments of platelet indices and their bioactivity may be of vital importance for monitoring the occurrence and progression of hypertension. Asgari et al [28] used the quadratic inference functions (QIFs) to determine the factors associated with obesity from the STEPS Survey in Iran.…”