Assessment of medication adherence and the costs associated with a calendar blister pack intervention among hypertensive patients in Malaysia: A randomized controlled trial

Tan, Bee Ying; Shafie, Asrul Akmal; Hassali, Mohamed Azmi; Saleem, Fahad

doi:10.1177/2050312117709189

Cited by 13 publications

(10 citation statements)

References 27 publications

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“…Therefore, we had a pool of patients with unpersonalized exposure toward learned skills, whereby merely reading and receiving information was insufficient to boost self-efficacy among stroke patients who were susceptible emotionally. In terms of blood-pressure control, our analysis contradicted recent studies that found poor medication-adherence rates negatively to affect blood-pressure control 36,52–54. Discrepancies would have possibly occurred due to variance in study objectives, patient samples, and type of intervention.…”

Section: Discussioncontrasting

confidence: 95%

<p>Exploring stroke survivors’ self-efficacy in understanding and taking medication and determining associated factors: a cross-sectional study in a neurology clinic in Malaysia</p>

Appalasamy¹,

Joseph

Ramaiah³

et al. 2019

PPA

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Background and aimEvidence-based prescribing practices for stroke-preventive medication have benefited stroke survivors; however, medication-nonadherence rates remain high. Medication understanding and use self-efficacy (MUSE) has shown great importance in medication-taking behavior, but its relationship with medication nonadherence in stroke-preventive regimens lacks exploration. The aim of this study was to determine the prevalence of MUSE and its association with nonadherence causes and other potential factors among stroke survivors in Malaysia.MethodsThis cross-sectional study was conducted among 282 stroke patients who provided informed consent and were in follow-up at the Neurology Outpatient Department of Hospital Kuala Lumpur, Malaysia. The study employed a data-collection form that gathered information on sociodemographics, clinical treatment, outcome measures on MUSE, and medication-nonadherence reasons.ResultsThe prevalence of poor medication understanding and use self-efficacy among stroke patients was 46.5%, of which 29.1% had poor “learning about medication” self-efficacy, while 36.2% lacked self-efficacy in taking medication. Beliefs about medicine (74.02%) was the commonest reason for medication nonadherence, followed by medication-management issues (44.8%). In the multivariate model, independent variables significantly associated with MUSE were health literacy (AOR 0.2, 95% CI 0.069–0.581; P=0.003), medication-management issues (AOR 0.073, 95% CI 0.020-0.266; P<0.001), multiple-medication issues (AOR 0.28, 95% CI 0.085–0.925; P=0.037), beliefs about medicine (AOR 0.131, 95% CI 0.032–0.542; P=0.005), and forgetfulness/convenience issues (AOR 0.173, 95% CI 0.050–0.600; P=0.006).ConclusionThe relatively poor learning about medication and medication-taking self-efficacy in this study was highly associated with health literacy and modifiable behavioral issues related to nonadherence, such as medication management, beliefs about medicine, and forgetfulness/convenience. Further research ought to explore these underlying reasons using vigorous techniques to enhance medication understanding and use self-efficacy among stroke survivors to determine cause–effect relationships.

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Section: Discussioncontrasting

confidence: 95%

<p>Exploring stroke survivors’ self-efficacy in understanding and taking medication and determining associated factors: a cross-sectional study in a neurology clinic in Malaysia</p>

Appalasamy¹,

Joseph

Ramaiah³

et al. 2019

PPA

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“…It is also worth mentioning that studies on medication adherence in Malaysia were mainly conducted among the general adult population [53][54][55]. Our meta-analysis indicated that more than half of the elderly in Malaysia were not adherent to their medications.…”

Section: Discussionmentioning

confidence: 84%

Prevalence of Drug-Related Problems and Complementary and Alternative Medicine Use in Malaysia: A Systematic Review and Meta-Analysis of 37,249 Older Adults

et al. 2021

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Drug-related problems (DRPs) in the elderly include polypharmacy, potentially inappropriate medications, nonadherence, and drug-related falls. In this systematic review and meta-analysis, the prevalence of DRPs and complementary and alternative medicine (CAM) use among the Malaysian elderly was estimated. PubMed, Scopus, Web of Science, and Google Scholar databases were searched to identify studies published since their inception up to 24 August 2020. A random-effects model was used to generate the pooled prevalence of DRPs along with its corresponding 95% confidence interval (CI). The heterogeneity of the results was estimated using the I2 statistics, and Cochran’s Q test and sensitivity analyses were performed to confirm the robustness of the results. We identified 526 studies, 23 of which were included in the meta-analysis. (n = 29,342). The pooled prevalence of DRPs among Malaysian elderly was as follows: (1) polypharmacy: 49.5% [95% CI: 20.5–78.6], (2) potentially inappropriate medications: 28.9% [95% CI: 25.4–32.3], (3) nonadherence to medications: 60.6% [95% CI: 50.2–70.9], and (4) medication-related falls 39.3% [95% CI: 0.0–80.8]. Approximately one in two Malaysian elderly used CAM. The prevalence of polypharmacy and potentially inappropriate medications among the Malaysian elderly population was high, calling for measures and evidence-based guidelines to ensure the safe medication use.

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“…Increased adherence has previously been demonstrated in trials of blister packaging programs for psychiatric medications and hypertensive medications. 11,12 A study investigating the use of blister packaging for multiple medications in elderly patients showed improvements in blood pressure and LDL measurements. 13 This broader application could subsequently lead to improved overall outcomes of our patient populations, particularly those at risk for more severe disease.…”

Section: Discussionmentioning

confidence: 99%

Customized blister packaging for patients living with HIV: assessment of patient attitudes and satisfaction

2020

GMERJ

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Adherence to antiretroviral medication results in reduced HIV transmission and improved health outcomes, yet challenges with medication adherence remain. A Collaborative Care Program was developed with a community pharmacy integrating a multi-dose adherence packaging service. We surveyed program participants to assess their satisfaction with this program and found an overall positive sentiment toward the program, that the program helped with reducing missed doses, and all patients would recommend the program to others.

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Assessment of medication adherence and the costs associated with a calendar blister pack intervention among hypertensive patients in Malaysia: A randomized controlled trial

Cited by 13 publications

References 27 publications

<p>Exploring stroke survivors’ self-efficacy in understanding and taking medication and determining associated factors: a cross-sectional study in a neurology clinic in Malaysia</p>

<p>Exploring stroke survivors’ self-efficacy in understanding and taking medication and determining associated factors: a cross-sectional study in a neurology clinic in Malaysia</p>

Prevalence of Drug-Related Problems and Complementary and Alternative Medicine Use in Malaysia: A Systematic Review and Meta-Analysis of 37,249 Older Adults

Customized blister packaging for patients living with HIV: assessment of patient attitudes and satisfaction

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