Assessment of mental deterioration with the Cognitive Abilities Screening Instrument (CASI) and glucose hypometabolism in Alzheimer’s disease: The Osaki-Tajiri Project

Yamaguchi, Satoshi; Meguro, Kenichi; Ishii, Hiroshi; Meguro, Mitsue; Akanuma, Kyoko

doi:10.1016/j.jocn.2009.01.018

Cited by 9 publications

(10 citation statements)

References 20 publications

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“…In addition, we found a significant negative association between FT3 level and aberrant motor behavior scores on the NPI. These specific cognitive and neuropsychiatric symptoms are both related to the fontal cortex [24][25][26], and our results may be supported by previous pathology findings in which the prefrontal cortices of patients with AD had significantly lower levels of T3, but not T4, compared with controls [38].…”

Section: Discussionsupporting

confidence: 89%

“…Because aberrant motor behavior is related to frontal behavior symptoms [24][25], and the four subfactors of the CASI (abstract thinking/judgment, verbal fluency, attention, and concentration) are classified into a frontal cortex cluster [26], we included these cognitive subfactors as predictors when FT3 was used as a dependent variable. Because a link between depression, anxiety, and HPA axis overdrive [11] has been reported to be related to prefrontal cortex regulation [27], we also included the GDS scores, anxiety scores of the NPI, and the four frontal related subfactors of the CASI as predictors when cortisol level was used as a dependent variable.…”

Section: Resultsmentioning

confidence: 99%

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The Relationship Between Thyroid Status, Cortisol Level, Cognition And Neuropsychiatric Symptoms In Patients With Alzheimer Disease

Chang¹,

Wu²,

Wang³

et al. 2018

Neuropsychiatry

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Objective: Growing evidence suggests an association between alterations in thyroid function and cortisol level and the pathogenesis and progression of Alzheimer disease (AD). The aim of this study was to investigate whether these hormones are related to the cognitive and neuropsychiatric manifestations in the patients with AD.Methods: This was a cross-sectional, case control study. Cortisol level and thyroid status were evaluated in 40 outpatients with mild to moderate AD and 20 normal controls, and cognitive and neuropsychiatric assessments were performed using the Cognitive Ability Screening Instrument (CASI), Neuropsychiatric Inventory, and Geriatric Depression Scale. Results:The patients had worse cognitive function and lower free triiodothyronine (FT3) level than the controls. Those with aberrant motor behavior had a lower FT3 level, and those with dysphoria had a higher cortisol level than those without these symptoms. The patients with a higher level of FT3 also had higher concentration and abstract thinking/judgment scores on the CASI, and those with a higher level of cortisol were associated with a decline in global cognition. Conclusion:Our results indicate a possible association between thyroid hormones and neuropsychiatric manifestations as well as cognitive function in euthyroid patients with AD, and suggest the potential efficacy of adjunctive T3 treatment in these patients. We hypothesize that patients with dysphoria subjectively experience more stress. Further studies are needed to elucidate whether this would increase the risk of depression or exacerbate cognitive function, and to investigate whether a non-pharmacological approach can relieve dysphoria symptoms according to the psychological attachment theory.

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Section: Discussionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

The Relationship Between Thyroid Status, Cortisol Level, Cognition And Neuropsychiatric Symptoms In Patients With Alzheimer Disease

Chang¹,

Wu²,

Wang³

et al. 2018

Neuropsychiatry

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“…It can assess a wide range of the participants' cognitive abilities in about 20 minutes and is considered to be useful for community-based studies. We previously 18 investigated the relationships between CASI domain scores and cerebral glucose metabolism as shown by positron emission tomography, and found that the most domains were correlated with the left frontal, temporal, and angular gyrus metabolism, suggesting that the mental dysfunctions assessed using CASI were neurobiologically meaningful.…”

Section: Assessment Of Cognitive Functionsmentioning

confidence: 99%

Disturbances in Everyday Life Activities and Sequence Disabilities in Tool use for Alzheimer Disease and Vascular Dementia

Okazaki

Kasai²,

Meguro³

et al. 2009

Cognitive and Behavioral Neurology

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“…: bilateral upper frontal (OM + 90 mm); parieto‐temporal (OM + 70 mm); medial frontal, lateral frontal, temporal, thalamus, and occipital (OM + 50 mm); inferior frontal, inferior temporal, and hippocampus (OM + 30 mm). The detailed methodology was previously described . The CMRglc was calculated as mg/100 mg/minute.…”

Section: Methodsmentioning

confidence: 99%

Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal glucose metabolism. A retrospective data analysis from the Tajiri Project

Meguro¹,

Meguro

Takahashi³

et al. 2019

Psychogeriatrics

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Background Alzheimer disease (AD) patients demonstrate various clinical features reminiscent of children (the retrogenesis model). The Binet test is available for assessing mental development and deterioration. However, neuroimaging correlations remain to be clarified. Although AD patients also manifest social judgment disability, there are few cognitive tests, contrary to so many memory tests. Among the database, we noticed that the Binet test includes the subscale of social judgement using illogical sentences and pictures. The aim of this study is to clarify the neuroimaging correlations for the Binet test, especially for the illogical questions. Methods Forty participants were selected from the database of the Tajiri Project. The Tanaka‐Binet test was used to evaluate the mental age and the basic age. The latter is the age level at which the patient can completely accomplish all questions at the immediately lower age level and is used for calculating the mental age. Using the subtests of illogical sentences/pictures, logical judgment abilities were assessed. Using magnetic resonance imaging, we performed four‐grade visual evaluation for cortical atrophy. The cerebral metabolic rate for glucose (CMRglc) was measured using an autoradiographic method of 18F‐fluoreodeoxyglucose – positron emission tomography (FDG‐PET). Results There was a significant Spearman's correlation between the clinical stage and the basic age. Degree of frontal, temporal and hippocampal atrophy were correlated with the basic age. The entire grey matter and frontal and temporal CMRglc were associated with the basic age. The illogical sentences scores were correlated with the bilateral temporal, hippocampal and the left parieto‐temporal CMRglc, whereas the illogical picture scores were correlated with the right parieto‐temporal CMRglc. Conclusions We found that frontal and temporal atrophy as well as hypometabolism were associated with the basic age. Regarding the illogical judgment, the current PET data analysis disclosed that there may be a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal areas.

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Assessment of mental deterioration with the Cognitive Abilities Screening Instrument (CASI) and glucose hypometabolism in Alzheimer’s disease: The Osaki-Tajiri Project

Cited by 9 publications

References 20 publications

The Relationship Between Thyroid Status, Cortisol Level, Cognition And Neuropsychiatric Symptoms In Patients With Alzheimer Disease

The Relationship Between Thyroid Status, Cortisol Level, Cognition And Neuropsychiatric Symptoms In Patients With Alzheimer Disease

Disturbances in Everyday Life Activities and Sequence Disabilities in Tool use for Alzheimer Disease and Vascular Dementia

Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal glucose metabolism. A retrospective data analysis from the Tajiri Project

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