Assessment of MIP1a and MIP1B in Iraqi women with polycystic ovarian syndrome

Abstract

Polycystic ovary syndrome (PCOS) is reproductive, endocrine and metabolic disorder. The pathology of PCOS is complicated and associated to chronic low-grade inflammation. Which associated with high level of pro-inflammatory cytokines, chemokines and leukocyte count. Inflammation of the ovary effects on ovulation and induce or aggravates systemic inflammation. MIP-1 proteins are tiny (8-10 kDa), pro-inflammatory chemokines of the CC subfamily, one of four chemokine families identified by their primary structure (i.e., CXC, C, CC, and CX3C). T- and B-lymphocytes, neutrophils, Macrophages, mast cells, dendritic cells and natural killer cells are all capable of producing large amounts of MIP-1. Materials and Methods: The research was performed on two groups, from 60 PCOS women and 30 control women during the period from October 2022 to January 2023. The diagnosis of PCOS women was based on two out of three of the following diagnostic criteria (hyperandrogenism - oligo or anovulation - polycystic ovaries). MIP-1 alpha and Beta levels were detected by ELISA. Results: The outcomes revealed that 60 women with PCOS showed significant increase (P<0.05) in the level of MIP1 alpha (635.28 ±20.58) while in women without PCOS was (571.20 ±25.92) , as well as non-significant increase the level of MIP1 beta in women with PCOS (191.85 ±17.54) while in control group (165.31 ±11.01). Conclusion: The current study concluded that MIP1 alpha and MIP1 beta increase, this prove that PCOS is low grade chronic inflammation.