Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Pandey, Geeta; Jain, Gourav

doi:10.3923/ajb.2015.267.280

Cited by 9 publications

(7 citation statements)

References 60 publications

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“…Thus, the observed reduction in the testicular protein content in DEX control rats could be attributed to disturbances in protein metabolism due to DEX‐induced testicular injury and could impair maturation of sperm. A similar decline in testicular protein content has been reported by Pandey & Jain () who stated that ammonium molybdate administration causes a significant decline in testicular protein level. The restoration of the testicular protein content after GSE administration could improve sperm maturation, which shows the androgenic potential of the extract.…”

Section: Discussionsupporting

confidence: 86%

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Hasona

2018

Andrologia

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This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX + GSE (200 mg/kg body weight) group and DEX + GSE (400 mg/kg body weight) group. The body weight gain and testes weight were assessed. Plasma testosterone and thyroid profile were determined. Testicular glucose-6-phosphate dehydrogenase (G-6-PDH), acid phosphatase (ACP), total protein and glutathione (GSH) levels, as well as catalase (CAT) activity also histopathological changes of the testis were evaluated. DEX treatment caused a significant decrease in body weight gain and weight of testes. Significant alterations in enzymatic and nonenzymatic antioxidants were observed. Moreover, a marked reduction in plasma testosterone levels and thyroid profile was observed. The administration of GSE significantly attenuated the deleterious effects of oxidative stress induced by DEX, as well as attenuated DEX-induced testicular and thyroid damage. Furthermore, DEX induced histological alterations in the testis. GSE ameliorated the injurious effects of DEX and improved the histological alterations in the testis.

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Section: Discussionsupporting

confidence: 86%

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Hasona

2018

Andrologia

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“…The results exhibited a significant drop in the serum level of testosterone in CB10 and CB40 groups than in the control group. This decrease was dose-dependent, agreeing with Pandey and Jain 64 findings. Meeker et al 65 showed a decline in testosterone levels after Mo exposure in a case study.…”

Section: Discussionsupporting

confidence: 91%

“…Meeker et al 65 showed a decline in testosterone levels after Mo exposure in a case study. The decline in testosterone levels in the rats nourished on CB fertilized by MoO 3 -NPs could be attributed to a reduction in the pituitary LH secretion or underutilization of cholesterol in testosterone synthesis 64 . Increased oxidative stress could potentially affect the Leydig cells' ability to operate normally.…”

Section: Discussionmentioning

confidence: 99%

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The effect of exposure to MoO3-NP and common bean fertilized by MoO3-NPs on biochemical, hematological, and histopathological parameters in rats

Shaban

Salama

El‐Aziz

et al. 2022

Sci Rep

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Nanotechnologies has been used to introduce several beneficial tools in the agricultural field. Herein, the effect of molybdenum oxide nanoparticles (MoO3-NPs) was investigated by evaluating the hematological, biochemical, and histopathological parameters in rats orally exposed to MoO3-NPs or fed common beans (CB) fertilized by MoO3-NPs. In the first study, 18 rats were randomly divided into 3 groups: G1 (control group) was given water orally, while G2 and G3 were administered 10 and 40 ppm MoO3-NPs by oral gavage tube, respectively. There was a significant increase in the levels of alanine aminotransferase (ALT), albumin, and total protein; however, there was a a significant decrease in body weight change (BWC), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine, creatine kinase–MB (CK-MB), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and testosterone levels in G3 compared to G1. In the second study, 24 rats were divided into 4 groups: the control (C) group was fed a balanced diet, and three groups were fed on a balanced diet plus 10% CB that was fertilized with 0, 10, and 40 ppm MoO3-NPs, resulting in nCB, CB10, and CB40 groups, respectively. This revealed a significant increase in BWC and total food intake (TFI) but a significant decrease in relative kidney weight in all the CB groups compared to the control group. In CB10 and CB40 groups ALT, LDH, TSH, FT3, and testosterone levels were significantly lower than the respective levels in the control group. We concluded that high doses of MoO3-NPs caused more side effects than low doses in both experiments.

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“…Lysosomal enzyme ACP is a biomarker of spermatogenesis steps mediated by androgenic influence 34 . Likewise, Alp is correlated with plasma membrane permeability and germ cell biomarkers in the cell 35 . The compromised plasma membrane integrity due to lipid peroxidation may have caused leakage of the enzyme resulting in the reduced activity of the enzymes.…”

Section: Discussionmentioning

confidence: 99%

Comparative Modulatory Assessment of the Sperm Quality and Testicular Function by Solvent Fractions of the Cannabis Extract in Rats

O¹,

Oluwafemi²,

E³

et al. 2021

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Background:The bioactive ingredients present in medicinal plants have various pharmacological activities which have explored for therapeutic and management of disease conditions like infertility. Objective: This study evaluated the comparative modulations on semen quality and testicular function in the rat by solvents soluble portions of ethanolic leaf extract in varying polar solvents. Methods: Thirty Wistar rats were randomly placed into five groups (A, B, C, D, E and F) with five rats per group: A, control: 0.2 ml 2 % DMSO was administered, B (vitamin C): 90 mg/kg body weight, 4.4 mg/kg body weight of n-hexane, 3.65 mg/kg body weight of ethyl acetate, 0.52 mg/kg body weight of n-butanol and 0.18 mg/kg body weight of the residual portion of Cannabis leaf extract were given to groups C, D, E and F, respectively. The rats were sacrificed 24 hours after the last day of 60 days of treatment. Results: Sperm indices, testosterone, FSH, LH, and HDL showed significant increase (p ≤ 0.05) across the treatment groups compared to normal control. Similarly, there was a significant increase in activity (p ≤ 0.05) of ALP, ACP, SOD, and CAT across the treatment groups compared to normal control. In addition, there were significant increases in GSH, MDA, triglyceride, cholesterol, total protein concentration levels across the treatment groups compared to normal control. The n-butanol soluble portion showed normal histomorphology with typical seminiferous tubule with spermatogonia lying on the basement membrane. Conclusion: Testicular integrity and improved sperm quality were pronounced in rats administered n-butanol solvent portion.

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Assessment of Molybdenum Induced Alteration in Oxidative Indices, Biochemical Parameters and Sperm Quality in Testis of Wistar Male Rats

Cited by 9 publications

References 60 publications

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

The effect of exposure to MoO3-NP and common bean fertilized by MoO3-NPs on biochemical, hematological, and histopathological parameters in rats

Comparative Modulatory Assessment of the Sperm Quality and Testicular Function by Solvent Fractions of the Cannabis Extract in Rats

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