Assessment of muscle strength and motor fatigue with a knee dynamometer in subjects with multiple sclerosis: a new fatigue index

Surakka, Jukka; Romberg, Anders; Ruutiainen, Juhani; Virtanen, Arja; Aunola, Sirkka; Mäentaka, Kari

doi:10.1191/0269215504cr781oa

Cited by 65 publications

(69 citation statements)

References 16 publications

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“…Most studies show that physical or muscular fatigue is higher in MS patients who subjectively reported fatigue than in healthy individuals [17,19,24]. The paradigm was transferred to the cognitive sphere, where cognitive fatigue was conceptualised as decreased performance over an extended time or after challenging effort [2,4,10,20].…”

Section: ■ Behaviour Aspectmentioning

confidence: 99%

Fatigue in neuroimmunological diseases

et al. 2007

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Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis (MS), myasthenia gravis, morbus Behcet, neurosarcoidosis, neuroborreliosis or immune vasculitis. This phenomenon is best investigated in MS. The complex mechanisms underlying fatigue in MS are still poorly understood; alterations in immune system activation, central nervous system dysregulation, impaired nerve conduction, and neuroendocrine dysregulation have to be considered. These immune and neural mechanisms may cause the initial symptoms of fatigue; however, the fatigue symptom may be exacerbated by secondary overlapping factors (e. g. depressive mood, sleep disturbances, unhealthy life style) which are likely associated with the feeling of fatigue. Wessely conceptualised four components of fatigue: behaviour (effects of fatigue), feeling (subjective experience), mechanisms, and context (e. g. environment, attitudes). So far most examinations have dealt with the first or the second component of the multidimensional construct fatigue, either concentrating on the behavioural aspect in the physical or in the cognitive sphere or on the subjective aspect. The Rostock Fatigue Study investigated two of the components: objective performance and subjective fatigue estimation in the cognitive and in the physical sphere. MS patients showed a reversed relationship between below-average objective performance in the cognitive and in the physical sphere and high subjective feeling of tiredness when compared to healthy individuals. The clinical management of fatigue should include an assessment of the various factors that can cause fatigue as well as a step-wise treatment approach that encompasses nonpharmacological approaches and pharmacological interventions.

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Section: ■ Behaviour Aspectmentioning

confidence: 99%

Fatigue in neuroimmunological diseases

et al. 2007

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“…Interest in the clinical measurement of fatigue in conditions such as multiple sclerosis (5,(8)(9)(10) amyotrophic lateral sclerosis (6), post polio (11)(12)(13)(14)(15), hereditary motor and sensory neuropathy (16) and Parkinson's disease (17) has increased in the recent past. There are now several published methods of measuring motor fatigue that can be used clinically (5,6,(11)(12)(13)16,17).…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of motor fatigue: Normative values and comparison with prior‐polio patients

Meldrum

Cahalane

Conroy

et al. 2007

Amyotrophic Lateral Sclerosis

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Motor fatigue is a common complaint of polio survivors and has a negative impact on activities of daily living. The aim of this study was to establish a normative database for hand grip strength and fatigue and to investigate differences between prior-polio subjects and normal controls. Static and dynamic hand grip fatigue and maximum voluntary isometric contraction (MVIC) of hand grip were measured in subjects with a prior history of polio (n = 44) and healthy controls (n = 494). A normative database of fatigue was developed using four indices of analysis. Compared with healthy controls, subjects with prior polio had significantly reduced hand grip strength but developed greater hand grip fatigue in only one fatigue index. Quantitative measurement of fatigue in the prior-polio population may be useful in order to detect change over time and to evaluate treatment strategies.

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“…As numbers were quite small, it is quite possible that an existing relationship was not identified, although it could also indicate that motor and subjective fatigue are completely different and unrelated constructs. Studies in Multiple Sclerosis have found little evidence of a correlation between motor fatigue and reports of subjective fatigue, mobility and function (Schwid et al, 1999;Surakka et al, 2004). We found no evidence that motor fatigue independently influenced mobility, while muscle strength was confirmed as an important factor associated with mobility (Gylfadottir, Dallimore, and Dean, 2006).…”

Section: Discussionmentioning

confidence: 53%

Assessment of subjective and motor fatigue in Polio survivors, attending a Postpolio clinic, comparison with healthy controls and an exploration of clinical correlates

Murray

Hardiman

Meldrum

2013

Physiotherapy Theory and Practice

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Assessment of muscle strength and motor fatigue with a knee dynamometer in subjects with multiple sclerosis: a new fatigue index

Abstract: Maximal isometric torque and motor fatigue of knee flexor and extensor muscles can be reliably measured using a knee dynamometer in MS patients. The new FI proved to be a reliable model for MS patients.

Cited by 65 publications

References 16 publications

Fatigue in neuroimmunological diseases

Fatigue in neuroimmunological diseases

Quantitative assessment of motor fatigue: Normative values and comparison with prior‐polio patients

Assessment of subjective and motor fatigue in Polio survivors, attending a Postpolio clinic, comparison with healthy controls and an exploration of clinical correlates

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