Assessment of myocardial blood flow (MBF) in humans using arterial spin labeling (ASL): Feasibility and noise analysis

Zun, Zungho; Wong, Eric C.; Nayak, Krishna S.

doi:10.1002/mrm.22088

Cited by 65 publications

(122 citation statements)

References 37 publications

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“…In this study, the relative dispersion of measured MBF from normal patients at rest was 0.68 (range 0.11 to 1.52) with 6 myocardial segments. This value is larger than that reported with other modalities, likely due to the higher level of physiological noise in myocardial ASL (10).…”

Section: Figure 3 Segmental Mbf Estimates At Rest and During Stresscontrasting

confidence: 66%

“…Each breath-hold lasted 10 s, and the total scan time was 3 min (including breaks). The myocardial ASL pulse sequence is fully described by Zun et al (10).…”

Section: E T H O D Smentioning

confidence: 99%

“…Imaging methods. Myocardial ASL was performed at a single mid-short-axis slice using FAIR tagging and balanced SSFP imaging (10). Tagging was achieved by applying nonselective and selective adiabatic inversions.…”

Section: E T H O D Smentioning

confidence: 99%

See 2 more Smart Citations

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

Zun

Varadarajan

Pai

et al. 2011

JACC: Cardiovascular Imaging

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Section: Figure 3 Segmental Mbf Estimates At Rest and During Stresscontrasting

confidence: 66%

“…Each breath-hold lasted 10 s, and the total scan time was 3 min (including breaks). The myocardial ASL pulse sequence is fully described by Zun et al (10).…”

Section: E T H O D Smentioning

confidence: 99%

See 1 more Smart Citation

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

Zun

Varadarajan

Pai

et al. 2011

JACC: Cardiovascular Imaging

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show abstract

“…It has been used in the kidney to characterise renal cell carcinoma [93] and other renal masses in those with renal failure [94]. Studies have also been performed in the lung [95], retina [96], heart [97] and skeletal muscle [98]. In the brain, tumour perfusion values have been shown to correlate with the histological grade of tumour.…”

Section: Arterial Spin Labellingmentioning

confidence: 97%

Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials

Fowkes

Koh

Collins³

et al. 2015

Pediatr Radiol

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Cancer is the leading cause of death in children older than 1 year of age and new drugs are necessary to improve outcomes. Imaging is crucial to the drug development process and assessment of therapeutic response. In adults, tumours are often assessed with CT using size criteria. Unfortunately, techniques established in adults are not necessarily applicable in children due to differing pathophysiology, ability to cooperate and increased susceptibility to ionising radiation. MRI, in particular quantitative MRI, has to date not been fully utilised in children with extracranial neoplasms. The specific challenges of imaging in children, the potential for functional imaging techniques to inform upon and their inclusion in clinical trials are discussed.

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“…Currently, PASL has advantages in dynamic ASL imaging and complex blood flow regions, such as myocardial [36] and lung [37] perfusion imaging.…”

Section: Tagging Pulsementioning

confidence: 99%

Accuracy of Arterial Spin Labeling in Magnetic Resonance Imaging

Li¹

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Cerebral perfusion imaging provides information about the blood supply of tissue. It reveals functional changes of the brain before and after structural changes, which can be used to improve the sensitivity and accuracy of stroke and tumor diagnosis. There has been an increasing interest in developing methods for non-contrast perfusion imaging, because of the risk of nephrogenic systemic fibrosis (NSF) in patients with kidney dysfunction and the need for repeated blood flow measurements in a short period of time for functional studies.Magnetic resonance imaging (MRI) provides a safer option for perfusion imaging without a contrast agent: arterial spin labeling (ASL). In this work, we propose several new techniques to improve the quality and quantification of ASL MRI.Using the water spins of blood as a tracer makes ASL safer than other perfusion imaging methods, but also results in a low signal-noise-ratio (SNR). Conventionally, ASL uses lengthy scan times to improve image quality and compensate for motion. However, this strategy is typically used to measure the perfusion bolus at a single time point, which can limit the accuracy of perfusion quantification, particularly in the setting of disease. Measuring multiple time points, which is called dynamic ASL, can improve quantification of cerebral ii iii blood flow (CBF) and yield additional information, but long scan times may be needed. In this work, we describe the following advances that can be used to improve dynamic ASL:(1) accurate reference T 2 mapping; (2) robust and rapid single-shot data acquisition; (3) dynamic model-based image reconstruction; and (4) optimal experiment design.As a parameter estimation problem, CBF is quantified based on other reference parameters, such as T 1 and T 2 . Here, I introduce a novel T 2 mapping paradigm, which combines the conventional image reconstruction and parameter regression steps into one state tracking step. Using the unscented Kalman filter (UKF), the proposed method uses a T 2 decay model to estimate T 2 information from k-space data directly and efficiently. It achieves accurate estimation up to an undersampling factor of 8, which is comparable to a compressed sensing method with model-based sparsity. This new paradigm can be adapted to Cartesian and non-Cartesian trajectories, and other parameter mapping models.In order to improve ASL image quality, a rapid and robust ASL sequence was developed with a combined parallel and compressed sensing image reconstruction. Pseudo continuous radio frequency (RF) pulses are used to tag the proximal blood. A 3D turbo spin echo sequence with stack-of-spiral readouts [1] is used to acquire k-space data. Additionally, pulsatile motion artifacts are corrected by exploiting the redundancy among multiple receiver coils. A dual-density spiral trajectory is used to achieve single-shot imaging, which improves the SNR and freezes motion. ASL image quality and SNR are further improved by parallel reconstruction with spatial sparsity constraints.Accurate CBF mapping requires dy...

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Assessment of myocardial blood flow (MBF) in humans using arterial spin labeling (ASL): Feasibility and noise analysis

Cited by 65 publications

References 37 publications

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

Childhood extracranial neoplasms: the role of imaging in drug development and clinical trials

Accuracy of Arterial Spin Labeling in Magnetic Resonance Imaging

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