Assessment of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with high myopia

Abstract

Background Previous reports have suggested that inflammation levels play a crucial role in the pathogenesis of high myopia (HM). This study aimed to investigate the relationship between HM and systemic inflammation using the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Methods Overall, 100 age- and sex-matched participants were recruited for the study, including 50 participants each in the non-HM (NHM) and HM groups. Ocular examinations and blood tests were performed. The NLR and PLR values were calculated from complete blood counts. Receiver operating characteristic (ROC) curves and optimal cut-off values were used to determine the optimal values of the NLR and PLR to distinguish between the HM and NHM groups. Results The values of NLR and PLR were significantly elevated in the HM group compared with those in the NHM group (P < 0.001 and P = 0.010, respectively). Axial length (AL) was significantly correlated with the NLR (r = 0.367, P < 0.001) and PLR (r = 0.262, P = 0.009). In the ROC analysis, the NLR value to distinguish between the HM and NHM groups was 0.728; the best cut-off value was 2.68, with 76% sensitivity and 62% specificity. The PLR value to distinguish between the HM and NHM groups was 0.650; the best cut-off value was 139.69, with 52% sensitivity and 76% specificity. Conclusion The findings of this study indicate that the development of HM may be associated with systemic inflammation measured using the NLR and PLR. Trial registration The study was registered on December 28, 2021 (http://www.chictr.org.cn; ChiCTR2100054834).

Gut microbiome and plasma metabolome alterations in myopic mice

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“…Meanwhile, elevated circulating neutrophils as well as decreased monocytes, eosinophils, and lymphocytes were found during the progression of myopia ( 20 ). As indicators of systemic inflammatory properties ( 21 ), significantly higher neutrophil-to-lymphocyte ratios and platelet-to-lymphocyte ratios in the peripheral blood of patients with high myopia ( 22 , 23 ) also implied higher inflammation and dysregulation of serum immune cells in high myopia population than in normal subjects. Significant elevations in high-sensitivity C-reactive protein and the complement profile in the peripheral blood of patients with pathological myopia ( 24 ) suggested the presence of systemic immune microinflammation in pathological myopia.…”