Assessment of nutritional status in HIV-positive population

Hakim, El Alama; Touria, Fatihi; Benmoussa, Adnane; Barkat, Amina

doi:10.1007/s13596-020-00444-8

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Furthermore, albumin and pre-albumin are often used as indicators of nutritional status, while albumin represents a key component of the NRI that serves for an in-depth evaluation of the nutritional profile [ 45 ]. On the one hand, the negative correlation between the NRI and plasma viral load suggests that correcting for under-nutrition would improve on anthropometric measurements, thus contributing in the control of viral replication and an improved health condition of PLHIV [ 28 ]. On the other hand, total protein is mainly an inflammatory marker and is not a sign of malnutrition.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon

et al. 2021

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Background HIV management remains concerning and even more challenging in the frame of comorbidities like malnutrition that favors disease progression and mortality in resource-limited settings (RLS). Objective To describe the nutritional parameters of antiretroviral therapy (ART) recipients (without nutritional support) with respect to CD4 count and virological failure. Methods A cross-sectional study was conducted from October to December 2018 among 146 consenting participants enrolled in two health facilities of the East-Region of Cameroon. Socio-demographic data, basic clinical information and treatment history were collected; blood samples were collected by venipuncture for laboratory analysis (HIV-1 viral load, CD4 Tcells measurement and biochemical analysis) performed at the “Chantal Biya” International Reference Center”, Yaounde, Cameroon. The nutritional profile was assessed by using anthropometric and biochemical parameters. Data were analyzed using Excel 2016, Graph pad prism version 6; Spearman correlation and Kruskal-Wallis test were used; with p<0.05 considered statistically significant. Results Median [IQR] age was 42 [33–51] years, 76.0% (111/146) were female and median [IQR] duration on ART was 54 [28–86] months. Of these participants, 11.6% (17/146) were underweight based on the body mass index and 4.7% (7/146) were at the stage of advanced weight loss. According to immunovirological responses, 44.5% (65/146) were immunocompromised (CD4<500 cell/μl) and 75.3% (110/146) had an undetectable viremia (<40 copies/mL). CD4 count inversely correlated with total protein concentration (r = -0.18, p = 0.005**). Viremia was inversely correlated with albumin (r = -0.21; p = 0.047*), nutritional risk index (r = -0.28; p = 0.013*), total cholesterol (r = -0.27; p = 0.007**), and positively correlated with total protein (r = 0.27; p<0.001**) concentrations. Conclusion In this RLS, with patients having about five years of ART-experience, malnutrition appears to be driven mainly by a poor BMI, indicating that about one of ten patients falls within this severe condition. However, the largely normal nutritional profiles should be interpreted with caution, considering local realities and food support programs in place. The present outcomes highlight the need for monitoring nutritional status of people receiving ART in RLS, toward the design of optimal food interventions.

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Section: Discussionmentioning

confidence: 99%

“…The NRI, a nutritional status assessment index recommended in national nutritional programs, was estimated by the following formula: [ 28 ]…”

Section: Methodsmentioning

confidence: 99%

Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon

et al. 2021

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“…Birhane’s and Hailemariam’s studies found that the prevalence of undernutrition in PLWH in Ethiopia was 25.2 and 12.3%, respectively, as defined by the BMI criteria [ 16 , 17 ]. Other studies conducted in Brazil, Indonesia, and Morocco showed that 12.3 to 36.1% of PLWH met the BMI criteria for undernutrition [ 9 , 13 , 27 ]. However, few studies have been conducted to explore nutritional status in older PLWH.…”

Section: Discussionmentioning

confidence: 99%

“…Measures of nutritional status, including body mass index (BMI), waist circumference, and the levels of albumin, prealbumin, serum glucose, and vitamin D, were commonly used in previous studies [ 12 ]. The prevalence of undernutrition in PLWH varies depending on the characteristics of the included populations and the types of nutritional indicators used [ 13 – 15 ]. PLWH in developing countries or rural settings have been reported to have a higher prevalence of undernutrition than PLWH living in developed countries and urban settings [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Nutritional risk and nutritional status in hospitalized older adults living with HIV in Shenzhen, China: a cross-sectional study

et al. 2021

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Background Nutrition is a crucial factor that can impact morbidity and mortality in older people living with HIV (PLWH). Studies on nutritional risk and nutritional status in all age groups in PLWH have been conducted. However, few studies have focused on nutritional risk in older PLWH. This study aimed to describe the nutritional risk and nutritional status in older PLWH, and explore factors associated with nutritional risk and undernutrition status. Methods We conducted a cross-sectional study. We recruited participants aged 50 years or older from the Third People’s Hospital of Shenzhen from January 2016 to May 2019. Nutritional risk and nutritional status were evaluated by the Nutritional Risk Screening 2002 (NRS 2002) tool, body mass index (BMI), albumin level, and prealbumin level on the first day of admission. Logistic regression models were used to identify the factors associated with undernutrition based on the BMI, albumin, and prealbumin criteria. Results A total of 196 older PLWH were included in the analysis. We found that 36% of hospitalized older PLWH had nutritional risk, and 12–56% of them had undernutrition based on the BMI, albumin, and prealbumin criteria. An increased nutritional risk score was associated with older age (β = 0.265 CI [0.021, 0.096], P = 0.002), a higher viral load (β = − 0.186 CI [− 0.620, − 0.037], P = 0.028), a lower BMI (β = − 0.287 CI [− 0.217, − 0.058], P = 0.001), and a lower albumin level (β = − 0.324 CI [− 8.896, − 1.230], P = 0.010). The CD4 count was associated with the prevalence of undernutrition based on the albumin criterion (OR = 15.637 CI [2.742, 89.178], P = 0.002). Conclusion Our study indicated that nutritional screening, assessment, and management should be routinely performed in hospitalized older PLWH. HIV-specific measures should be used to assess nutritional risk, and albumin, BMI, and other assessments should be used in combination to identify undernutrition in older PLWH.

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Assessment of nutritional status in HIV-positive population

Cited by 2 publications

References 14 publications

Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon

Correlation between the immuno-virological response and the nutritional profile of treatment-experienced HIV-infected patients in the East region of Cameroon

Nutritional risk and nutritional status in hospitalized older adults living with HIV in Shenzhen, China: a cross-sectional study

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