“…Li et al [ 21 ] discovered that extracellular LUM enhances chemotherapy cytotoxicity in PDAC cells through reduced AMPK activity and inhibition of chemotherapeutic agent-induced autophagy. Nizet et al [ 22 ] showed that LUM primarily inhibits ovarian cancer growth by altering collagen fibrillogenesis. LUM expression differs among tumors and is reported as a reference for tumor prognosis, but its association with tumor progression and treatment resistance varies across tumors [ [22] , [23] , [24] ].…”