Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Mohideen, Khadijah; Chandrasekar, Kirubhanand; Ramsridhar, Saranya; Raj, A. Thirumal; Ghosh, Snehashish; Dhungel, Safal

doi:10.1155/2023/6014706

Cited by 16 publications

(3 citation statements)

References 74 publications

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“…Banasovà et al [15] analyzed the saliva of 42 patients (19 patients with periodontal disease and 23 healthy), and found that lipid peroxidation in periodontitis appears to be caused by an augmented production of reactive oxygen species (ROS) in males and a decrease in antioxidant status in females. The research of Mohideen et al [14] identified the mean levels of malondialdehyde (MDA), a lipid peroxidation biomarker, to differ significantly between healthy patients and those with periodontitis, with confirmation of increased ROS production on the part of the inflammatory cells in periodontitis.…”

Section: Discussionmentioning

confidence: 99%

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The Role of Salivary Biomarkers in Monitoring Oral Health in Patients with Implants and Periodontitis

López-Jornet,

Hynninen,

Parra-Perez

et al. 2024

Applied Sciences

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Oxidative stress, a physiological process that can damage cells, is known to affect various aspects of oral health. Oxidative stress can influence dental implant longevity and health. Assessing biomarkers of oxidative stress in saliva is beneficial for diagnosing and tracking the progression of oral diseases. A study is made of salivary oxidative stress in patients with dental implants with or without periodontitis. The study consisted of the following groups: Group1 (healthy without dental implants); Group 2 (subjects undergoing periodontal maintenance without dental implants); Group 3 (healthy patients with implants older than six months); and Group 4 (patients undergoing periodontal maintenance with implants older than six months). A complete examination of the oral cavity was made in each patient and a questionnaire was used to assess habits of hygiene, quality of life, and information about the implants. The following parameters were recorded in unstimulated whole saliva: ferric reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), advanced oxidation protein products (AOPP), and total proteins (TP). A total of 160 patients were studied, with 40 patients per group. The mean oxidative stress biomarker values obtained in the patients without implants and with implants were FRAP 0.590 ± 0.514 and 0.588 ± 0.334 mmol/L (p = 0.974); TEAC 0.320 ± 0.223 and 0.315 ± 0.172 mmol/L (p = 0.879); CUPRAC 0.286 ± 0.216 and 0.288 ± 0.151 mmol/L (p = 0.956); AOPP 456.04 ± 789.75 and 430.65 ± 752.05 µmol/L (p = 0.838); and TP 73.90 ± 50.83 and 70.36 ± 56.93 mg/dL (p = 0.684), respectively. No substantial variations were noted in the salivary oxidative stress biomarker levels between patients with controlled periodontal disease and/or dental implants compared to healthy individuals.

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Section: Discussionmentioning

confidence: 99%

“…Periodontitis is characterized by an increase in ROS at the periodontal level, resulting in oxidant imbalance [13][14][15][16]. Chen et al [9] observed notable changes in the biochemical markers of patients with periodontitis.…”

Section: Introductionmentioning

confidence: 99%

The Role of Salivary Biomarkers in Monitoring Oral Health in Patients with Implants and Periodontitis

López-Jornet,

Hynninen,

Parra-Perez

et al. 2024

Applied Sciences

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“…CAT could decompose hydrogen peroxide in the body and block the formation of free radicals ( Shi et al, 2023 ). MDA is one of the products of lipid peroxidation, exhibits cytotoxicity and genotoxicity, is an essential indicator of oxidative stress status, and indicates various diseases in the body ( Catalan et al, 2010 ; Mohideen et al, 2023 ). These results of serum indicators suggested that HBLS could enhance the antioxidant ability of horses.…”

Section: Discussionmentioning

confidence: 99%

Response of serum biochemical profile, antioxidant enzymes, and gut microbiota to dietary Hong-bailanshen supplementation in horses

Ding,

Gu,

Meng

et al. 2024

Front. Microbiol.

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BackgroundTraditional Chinese medicine (TCM) is widely used in humans and animals, which is very important for health. TCM affects the body ‘s immunity and changes in intestinal flora. This study was conducted to investigate the effects of dietary Hong-bailanshen (HBLS) supplementation in horses on serum biochemical profile, antioxidant enzymes and gut microbiota.MethodsIn this study, five horses were selected. On day 0, 14, 28, blood samples and feces were collected on days 0, 14, and 28 to analyse gut microbiota, serum biochemical and redox indexes.ResultsThe results showed that the addition of HBLS to horse diets significantly decreased the level of alanine aminotransferase, alkaline phosphatase, creatine kinase and malondialdehyde (p < 0.05, p < 0.01) and significantly increased the activity of total antioxidant capacity, superoxide dismutase and catalase (p < 0.05, p < 0.01). Compared with day 14, the levels of alanine aminotransferase, alkaline phosphatase and creatine kinase were significantly decreased; however, the level of catalase was significantly increased in the horses continuously fed with HBLS for 28 days (p < 0.05, p < 0.01). Alpha diversity analysis was performed that chao1 (p < 0.05), observed_specicies, faith’pd and goods_coverage upregulated in the horses fed HBLS. A total of 24 differential genera were detected adding HBLS to diet increased the abundance of Bacillus, Lactobacillaceae, Leuconostocaceae, Christensenellaceae, Peptostreptococcaceae, Faecalibacterium, Erysipelotrichaceae, Pyramidobacter, Sphaerochaeta, WCHB1-25, Bacteria, Oscillospira, and Acetobacteraceae, while reduced Aerococcus, EtOH8, Syntrophomonas, Caulobacter, Bradyrhizobiaceae, W22, Succinivibrionaceae, and Desulfovibrio (p < 0.05, p < 0.01).ConclusionAdding HBLS to the diet could be a potentially effective strategy to improve horses’ health.

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The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2

Yang,

Hu,

Wang

et al. 2024

Biotech and App Biochem

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Excessive inflammatory response and oxidative stress (OS) play an important role in the pathogenesis of spinal cord injury (SCI). Balance of inflammation and prevention of OS have been considered an effective strategy for the treatment of SCI. Hyaluronan and proteoglycan link protein 1 (HAPLN1), also known as cartilage link protein, has displayed a wide range of biological and physiological functions in different types of tissues and cells. However, whether HAPLN1 regulates inflammation and OS during SCI is unknown. Therefore, we aimed to examine whether HAPLN1 can have a protective effect on SCI. In this study, both in vitro and in vivo SCI models were established. Nissl staining and terminal deoxynucleotidyl transferase dUTP nick end labeling staining assays were used. Western blotting and enzyme‐linked immunosorbent assay were employed to assess the expression of proteins. Our results demonstrate that the administration of HAPLN1 promoted the recovery of motor neurons after SCI by increasing the Basso mouse scale score, increasing the numbers of motor neurons, and preventing apoptosis of spinal cord cells. Additionally, HAPLN1 mitigated OS in spinal cord tissue after SCI by increasing the content of superoxide dismutase SOD and the activity of glutathione peroxidase but reducing the levels of malondialdehyde. Importantly, we found that HAPLN1 stimulated the activation of the nuclear factor erythroid 2‐related factor 2 (Nrf2)/antioxidant response element (ARE) pathway and stimulated the expression of heme oxygenase‐1 and nicotinamide adenine dinucleotide phosphate quinone oxidoreductase‐1, which mediated the attenuation of HAPLN1 in activation of the NOD‐like receptor protein 3 (NLRP3) inflammasome by reducing the levels of NLRP3, apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC), caspase‐1, and interleukin‐1β. Correspondingly, in vitro experiments show that the presence of HAPLN1 suppressed the NLRP3 inflammasome and prevented cell injury against H2O2 in PC12 cells. These effects were mediated by the Nrf2/ARE pathway, and inhibition of Nrf2 with ML385 abolished the beneficial effects of HAPLN1. Based on these findings, we conclude that HAPLN1 inhibits the NLRP3 inflammasome through the stimulation of the Nrf2/ARE pathway, thereby suppressing neuroinflammation, enhancing motor neuronal survival, and improving the recovery of nerve function after SCI.

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Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Cited by 16 publications

References 74 publications

The Role of Salivary Biomarkers in Monitoring Oral Health in Patients with Implants and Periodontitis

The Role of Salivary Biomarkers in Monitoring Oral Health in Patients with Implants and Periodontitis

Response of serum biochemical profile, antioxidant enzymes, and gut microbiota to dietary Hong-bailanshen supplementation in horses

The effects of hyaluronan and proteoglycan link protein 1 (HAPLN1) in ameliorating spinal cord injury mediated by Nrf2

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