Assessment of pancreatic colloid carcinoma using 18F‑FDG PET/CT compared with MRI and enhanced CT

Abstract

Pancreatic colloid carcinoma (CC) is a rare sub-type of pancreatic adenocarcinoma which has an improved prognosis compared with pancreatic ductal carcinoma. Consequently, the early detection of CC by imaging may be of great significance in guiding patient management and therapeutic decisions. The present study aimed to analyze 18F-FDG PET/CT findings of CC in comparison to MRI and CT. PET/CT findings in 5 patients with CC were retrospectively reviewed based on visual interpretation and semi-quantitative index of SUVmax and TNR. Four patients received dual-time-point PET/CT scans. Additionally, one patient underwent contrast-enhanced CT scan, one MRI, and three received both. A total of five lesions were detected in five patients. Visually, two cases presented with mild FDG uptake, two with moderate and one with high. The mean of SUVmax and TNR was 5.1±2.2 and 2.8±0.7, respectively. Compared with CCs with low SUVmax, CCs with high SUVmax were more aggressive. No distant metastases were observed in five cases. Among four patients with dual-time-point PET/CT imaging, SUVmax increased in three cases and decreased in one case. The mean early and delayed SUVmax were 4.2±1.1 and 4.7±1.9, respectively (P>0.05). Radiological findings mainly included septated cystic components, internal sponge-like contrast-enhancement, calcification and ‘salt-and-pepper sign’ on MRI T2-weighted imaging. Thus, PET/CT provided additional information on metabolic tumor activity as well as locoregional and distant staging, which are important prognostic markers and may improve further patient management. However, PET/CT did not show any findings in addition to MRI and contrast-enhanced CT that were unique to CC and allowed a clear differentiation from other pancreatic malignancies.

Pancreatic Colloid Carcinoma Presenting with Acute Pancreatitis

“…Pancreatic colloid carcinoma was first described in a case report by Muir in 1952 (1,5). In a study of 17 patients di-agnosed with pancreatic colloid carcinoma in 2001, Adsay et al considered it a rare mucous-producing tumor that should be distinguished from other pancreatic neoplasms (1,6).…”

“…Pancreatic colloid carcinoma was first described in a case report by Muir in 1952 (1,5). In a study of 17 patients di-agnosed with pancreatic colloid carcinoma in 2001, Adsay et al considered it a rare mucous-producing tumor that should be distinguished from other pancreatic neoplasms (1,6). Colloid carcinoma of the pancreas, also known as mucinous noncystic carcinoma, is a rare pancreatic neoplasm and represents about 1% of all pancreatic tumors (3,6,7).…”

“…MUC1 appears to be a marker of an aggressive phenotype, such as pancreatic ductal carcinoma. MUC2 is commonly expressed in tumors with an indolent course, such as some IPMNs, and specifically in pancreatic colloid carcinomas involving different organs (1,8,9).…”

“…Pancreatic colloid carcinoma, also known as mucinous non-cystic adenocarcinoma, is a unique well-differentiated type of invasive adenocarcinoma of the pancreas (1). It is a rare subtype of pancreatic cancer that only accounts for only 1%-3% of the malignant neoplasms of the exocrine pancreas.…”

TEP/TDM multi-phase : revue de la littérature

“…Les performances de l'acquisition DTP des images TEP a fait l'objet de multiples articles dans l'exploration des tumeurs du pancré as depuis le dé but de l'usage de cette technique [13,[94][95][96][97][98][99][100][101][102][103][104]. Dans une sé rie de 47 patients pré sentant une suspicion de né oplasie du pancré as, Nakamoto et al ont ré alisé deux sé ries d'images 18 [104].…”