Abstract-Passive circumferential and axial mechanical properties of porcine coronary arteries and internal mammary arteries (IMA) were measured and compared. The cylindrical specimens were subjected to axial stretch and internal pressures up to 300 mmHg. Stress-strain relations of the arteries were calculated from the measured data and compared. It was found that the stresses in the IMA were much higher and that the IMA is stiffer than the coronary artery, especially in the circumferential direction. The axial stress in the coronary artery increased substantially after axial stretching, this in contrast to the axial stress in the IMA. Keywords-coronary artery, internal mammary artery, stress, strain, bypass
I. INTRODUCTIONCoronary artery bypass surgery is changing recently. Surgery on the beating heart with local mechanical stabilizers is practiced in 15-20 % of the cases worldwide. Telemanipulation systems are introduced that allow surgeons to explore minimally invasive coronary surgery [1]. These developments will require new techniques for coronary artery bypass grafting because of limited access and space. Many patents of facilitated anastomotic techniques show the use of anvils and other microstructures [2]. Applying such techniques often causes extreme deformations in the arterial wall of both donor and recipient vessel and this could lead to severe damage of arterial wall structures. These extreme deformations can initiate intimal hyperplasia, which could eventually lead to stenosis of the anastomosis. Therefore it is important to know more about the mechanical properties of arteries involved in coronary artery bypass surgery. We investigated the main coronary arteries and a graft, the IMA, because of its good clinical results [3].
II. METHODOLOGYFor this study the vessels of 13 healthy Landrace pigs (weight 70-90 kg) were used. The animals were sacrificed in the course of other experiments. A total of 8 cylindrical segments of coronary arteries and 6 segments of the IMA were harvested. All arteries were measured within 24 hours after termination. The coronary arteries were removed from the hearts, all side branches were carefully closed with small clips. Surrounding tissue and loose adventitial fibers were removed. The mechanical properties were measured by subjecting the arterial segments to inflation and axial tension in an experimental setup. Both ends of each arterial segment were connected to metallic cannulae with sutures. The cannulae were connected to a tensile testing machine with which both the axial lengthening of the segment could be regulated and the axial force was measured. In general, a segment of a vessel shortens after removal from the surrounding tissue. To approximate their original length, the arteries were given pre-stretches in the axial direction. The upper cannula was closed and the lower cannula was connected to a reservoir with Tyrode solution (in mM: NaCl 140; KCl 4.9; MgSO 4 1.2; NaH 2 PO 4 1.8 and Hepes 5). The cannulated segment was placed in a small chamber with parallel g...