Assessment of Pattern of Antimicrobial Resistance of Helicobacter Pylori in Patients of Dyspepsia of Rural Area

Malhotra, Yogendra; Khare, Rajeev Lochan; Varma, Sanjay; Toppo, Archana

doi:10.14260/jemds/2015/1566

Cited by 3 publications

(10 citation statements)

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“…Furazolidone was used in H. pylori treatment in India in the studies of Gehlot et al [ 25 ], Pandey et al [ 21 ], and Malhotra et al [ 27 ]. Despite of its infrequent use, the resistance was high (14%).…”

Section: Discussionmentioning

confidence: 99%

“… Forest Plot Showing Metronidazole Resistance. (*: the same study with data from two countries, Reference Studies: [ 14 , 15 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]). …”

Section: Figurementioning

confidence: 99%

“… Forest Plot Showing Clarithromycin Resistance. (Reference Studies: [ 15 , 20 , 21 , 22 , 23 , 24 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]). …”

Section: Figurementioning

confidence: 99%

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Drug Resistance Patterns of Commonly Used Antibiotics for the Treatment of Helicobacter pylori Infection among South Asian Countries: A Systematic Review and Meta-Analysis

et al. 2023

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Background: In South Asia, resistance to commonly used antibiotics for the treatment of Helicobacter pylori infection is increasing. Despite this, accurate estimates of overall antibiotic resistance are missing. Thus, this review aims to analyze the resistance rates of commonly used antibiotics for the treatment of H. pylori in South Asia. Methods: The systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. We searched five medical databases for relevant studies from inception to September 2022. A random effect model with a 95% confidence interval (CI) was used to calculate the pooled prevalence of antibiotic resistance. Results: This systematic review and meta-analysis included 23 articles, 6357 patients, 3294 Helicobacter pylori isolates, and 2192 samples for antibiotic resistance. The prevalences of antibiotic resistance to common antibiotics were clarithromycin: 27% (95%CI: 0.17–0.38), metronidazole: 69% (95%CI: 0.62–0.76), tetracycline: 16% (95%CI: 0.06–0.25), amoxicillin: 23% (95%CI: 0.15–0.30), ciprofloxacin: 12% (95%CI: 0.04–0.23), levofloxacin: 34% (95%CI: 0.22–0.47), and furazolidone: 14% (95%CI: 0.06–0.22). Subgroup analysis showed antibiotic resistances were more prevalent in Pakistan, India, and Bangladesh. Furthermore, a ten-year trend analysis showed the increasing resistance prevalence for clarithromycin (21% to 30%), ciprofloxacin (3% to 16%), and tetracycline (5% to 20%) from 2003 to 2022. Conclusion: This meta-analysis showed a high prevalence of resistance among the commonly used antibiotics for H. pylori in South Asian countries. Furthermore, antibiotic resistance has been increasing over the time of 20 years. In order to tackle this situation, a robust surveillance system, and strict adherence to antibiotic stewardship are required.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Drug Resistance Patterns of Commonly Used Antibiotics for the Treatment of Helicobacter pylori Infection among South Asian Countries: A Systematic Review and Meta-Analysis

et al. 2023

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“…Clarithromycin‐resistant H. pylori (Cla R ) was found in 33.39% (352/1054) samples. The resistance was highest in West India at 58.8% (47/80) followed by South India at 48.7% (208/427), Central India at 19.2% (5/26), and North India at 23.96% (81/338) 24 (Table 2). The resistance rate was 6.3% (11/172) in the Eastern regions and nil in the North‐Eastern regions of India (Figure S2).…”

Section: Resultsmentioning

confidence: 99%

“…Fewer data are available for resistance rates of certain antibiotics which are as follows ciprofloxacin in Gujarat (40/80, 50%), 22 Chhattisgarh (1/26, 3.8%), 24 and Lucknow (3/25, 12%); 23 for amoxicillin and tetracycline. 3 The maximum resistance rate was observed at 48.8% (39/80) for ciprofloxacin and clarithromycin.…”

Section: As Given Inmentioning

confidence: 99%

Primary antibiotic resistance of Helicobacter pylori in India over the past two decades: A systematic review

Dutta,

Jain,

Das

et al. 2024

Helicobacter

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BackgroundHelicobacter pylori antibiotic resistance has undergone vast changes in the last two decades. No systematic review has been done on the prevalence of antibiotic resistant H. pylori in India in the last two decades. We evaluated the pattern of resistance rates across various regions of India.Materials and MethodsA systematic review of the geographical variations in antibiotic resistance pattern of H. pylori was conducted using PubMed, Google Scholar, Web of Science, Science Direct, etc. for articles published between January 1, 2000 and May 30, 2023. Random effects‐model‐based Cochran's Q test, I2 statistics, and chi‐squared tests were used to measure heterogeneity.ResultsThe overall resistance was highest against metronidazole (77.65%) followed by amoxicillin (37.78%), levofloxacin (32.8%), clarithromycin (35.64%), furazolidone (12.03%), and tetracycline (11.63%). 14.7% of the H. pylori isolates were multi‐drug resistant. Under meta‐analysis of each antibiotic, high heterogeneity levels were observed having I2 ranges from 86.53% to 97.70% at p < 0.0001. In sub‐group analysis, Metronidazole has a stable rate of resistance as compared to other antibiotics. Other antibiotics have had a downtrend in the last 5 years except for levofloxacin, which has had an uptrend in the resistance rate for the past 5 years. Hence, one should avoid using metronidazole for any kind of first‐line treatment.ConclusionsMetronidazole resistance is high in most regions of India except Assam and Mumbai while clarithromycin is found to be ineffective in South India, Gujarat, and Kashmir. As compared to other antibiotics, resistance to amoxicillin is generally low except in certain regions (Hyderabad, Chennai, and the Gangetic belt of North India). Tetracycline and Furazolidone have the least resistance rates and should be part of anti‐ H. pylori regimens. The resurgence of high single and multidrug resistance to the commonly used drugs suggests the need for newer antibiotics and regular resistance surveillance studies.

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Choosing optimum regimen for treating Helicobacter pylori infection: Regional data may be the quintessential guide

Dutta

2023

Indian J Gastroenterol

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Assessment of Pattern of Antimicrobial Resistance of Helicobacter Pylori in Patients of Dyspepsia of Rural Area

Cited by 3 publications

References 3 publications

Drug Resistance Patterns of Commonly Used Antibiotics for the Treatment of Helicobacter pylori Infection among South Asian Countries: A Systematic Review and Meta-Analysis

Drug Resistance Patterns of Commonly Used Antibiotics for the Treatment of Helicobacter pylori Infection among South Asian Countries: A Systematic Review and Meta-Analysis

Primary antibiotic resistance of Helicobacter pylori in India over the past two decades: A systematic review

Choosing optimum regimen for treating Helicobacter pylori infection: Regional data may be the quintessential guide

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