BACKGROUND:Helicobacter Pylori is a gastric pathogen that chronically infects more than half of the world's population. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Helicobacter pylori eradication rate varies in different parts of the world. This may be related to the regional difference in anti-microbial resistance that affects the outcome of therapy, genetic difference in the metabolism of the proton pump inhibitor, which can also alter the availability of anti-microbial in the stomach.

Malaria is one of the major public health problems of our country. Around 1.5 million confirmed cases are reported annually by NVBDCP and there are estimated about 20000 deaths annually due to malaria. Severity Assessment and Risk stratification can help reduce this burden of mortality due to malaria. This study was aimed to assess the severity of organ dysfunction in malaria. To estimate the patient risk for mortality and Identification of patients at greater risk of complications. MATERIALS AND METHODS: This hospital based observational study was carried out from October 2012 to Sept 2013, 80 consecutive patients of plasmodium falciparum malaria, diagnosed and admitted in the Department of Medicine, Pt. J.N.M Medical college, Raipur, Chhattisgarh were studied and assessed on variables such as age, sex, vital signs, Hemoglobin, Total Count, Platelet Count, blood urea, serum creatinine, urine output, Serum Bilirubin, Serum glucose, MSS And classification for complicated versus uncomplicated as per WHO Criteria. RESULTS AND CONCLUSIONS: Most patients (76%) were young adult males and presented with fever (100%) and about 1/3 (27%) of patients presented in altered sensorium, there was correlation (P>0.05) between the high malaria severity scores and mortality and also 30% mortality was observed in complicated malaria versus 16% in uncomplicated malaria.

Background: Neutrophil lymphocyte is an indicator of subclinical inflammation. Type 2 diabetes mellitus is associated with chronic low-grade inflammation. One of the novel inflammatory markers is hemogram derived neutrophil to lymphocyte ratio. There are very few studies which are directly accessing the relation between NLR and HbA1c, so in the present study our aim to correlate neutrophil lymphocyte ratio with glycemic control in patients having type 2 diabetes.Methods: Hospital based observational cross section study was carried out at department of medicine, Pt JNMMC and Dr BRAM Hospital, Raipur, between September 2018 to August 2019. 105 patients with type 2 diabetes mellitus according to ADA criteria who were aged more than 18 years were included in the study. Relevant investigation and complete blood count were performed. Microsoft excel and SPSS version 25 were used for collection and analysis of the data, p<0.05 was considered as significant.Results: Out of 105 patients who were given the consent for the study, the ration of male is to female was 1:0.98, mean age of all the patients was 51.77±10.56 years, mean neutrophil lymphocyte ratio among the patients was 6.30±2.646, HbA1c count more than ≥9 was 54 (51.27%). NLR had a positive correlation with HbA1c and was found to be an independent predictor of poor glycemic control in patients with type 2 diabetes mellitus.Conclusions: Increased NLR is associated with elevated HbA1c and poor glycemic control. Type NLR should be used as a marker of diabetic control level in addition to HbA1c in type 2 diabetic subjects.

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