Health professionals caring for asylum seekers face decisions about whether to participate in force-feeding hunger strikers, performing and reviewing unnecessary x-rays to assess detainees' ages, misusing detainees' health information, and discharging patients based on immigration officials' demands rather than patient safety. The latter action is a classic dual-loyalty dilemma reminiscent of some clinicians' actions during the Holocaust. This article investigates how professional organizations can support clinicians targeted by the state for resisting immigration officials' demands for their participation in human rights violations, opposing policies that compromise health professional values, and refusing to engage in unethical detention practices. Dual Loyalty For centuries, health professionals have pledged uncompromising devotion to patients' well-being. Dual-loyalty conflicts arise when clinicians' duties to public health or third parties (health care organizations, insurance companies, family members, and others) conflict with their duties to individuals, particularly patients. Failure to navigate dual loyalties well undermines the integrity of patient-clinician relationships and even entire health professions' trustworthiness. When individual clinicians succumb to pressure from states or state authorities to prioritize nonclinical factors (eg, national security, immigration enforcement, or customs policies) above the interests of patient-detainees, they compromise fidelity to vulnerable persons who have few to whom they can turn. Training clinicians to resist commission of or complicity in human rights violations is expected of health professions educators seeking to help prepare graduates of their programs to resist state-sanctioned abuse and neglect. 1 Notorious examples of breaches of health professional ethics abound, from Nazi doctors' participation in "euthanasia" programs to US clinicians' participation in stateadministered torture and executions. 2,3,4,5 Although international codes and professional society statements have been invoked to prevent violations and hold perpetrators accountable, 6,7 the possible role of medical ethics and dual loyalty has been neglected in investigations of US clinicians' involvement in asylum seekers' and migrants' traumatic custody experiences of indefinite detention, overcrowding, and squalor.