Assessment of platelet activity as expressed by plasma levels of platelet factor 4 and β‐thromboglobulin in patients with chronic idiopathic urticaria

Kasperska−Zając, Alicja; Rogala, Barbara; Nowakowski, M.

doi:10.1111/j.0906-6705.2005.00311.x

Cited by 21 publications

(12 citation statements)

References 29 publications

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“…Increased MPV and PDW may indicate enhanced platelet activation in CSU, which is in contrast with previous observation regarding the systemic release of platelet factor 4 and beta-thromboglobulin, the indices of platelet activation [18], and in agreement with the study by Chandrashekar et al [21]. Very importantly, both the prothrombotic condition and the hypercoagulable state are not the established features of CSU.…”

Section: Discussionsupporting

confidence: 78%

“…It has been reported that platelet count is not increased in CSU [18]. Unfortunately, the patients were not divided by the disease activity/severity.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, it is known that IL-6 stimulates the synthesis of CRP and thrombocytosis [16, 17]. Data regarding platelet activation markers in CSU are scarce and contradictory [15, 18–21]. Taken together, it seems reasonable to determine the relationships between the platelet characteristics (count, MPV, and PDW) and serum concentration of CRP, the best marker of acute phase response, as well as their potential clinical use in CSU patients.…”

Section: Introductionmentioning

confidence: 99%

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The Association between Platelet Count and Acute Phase Response in Chronic Spontaneous Urticaria

Kasperska−Zając

Grzanka

Jarząb

et al. 2014

BioMed Research International

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Background. The platelet parameters and C-reactive protein (CRP) are markers reflecting a systemic inflammatory response. Among those, CRP is one of the major proteins helpful in determination of severity/activity of chronic spontaneous urticaria (CSU). Aim. To determine relationships between platelet activation indices and serum concentration of CRP, the best marker of acute phase response, and their potential clinical use in CSU patients. Methods. Mean platelet volume (MPV), platelet distribution width (PDW), and platelet count as well as serum CRP concentration were measured in CSU patients, showing different degrees of urticarial severity, and in the healthy subjects. Results. No significant differences were found in MPV and PDW between CSU group and the healthy subjects. The platelet count was significantly higher in moderate-severe CSU than that of the controls and mild CSU patients. Serum CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects and significantly correlated with the platelet count in CSU patients. Conclusions. Acute phase response in CSU is associated with the increased number of circulating platelets in patients with more severe symptoms. It seems that simple determination of platelet size indices is not a reliable indicator of CSU severity/activity.

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Section: Discussionsupporting

confidence: 78%

“…It has been reported that platelet count is not increased in CSU [18]. Unfortunately, the patients were not divided by the disease activity/severity.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Association between Platelet Count and Acute Phase Response in Chronic Spontaneous Urticaria

Kasperska−Zając

Grzanka

Jarząb

et al. 2014

BioMed Research International

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“…Earlier studies in CU by Kasperska-Zajac et al [79] failed to demonstrate platelet activation, as detected by plasma concentrations of PF-4 and/or β-thromboglobulin. In another study performed by the same authors [80], the circulating level of the platelet-derived chemokine PF-4 was not increased in CU patients, regardless of either the occurrence of euthyroid Hashimoto's thyroiditis or the response to ASST.…”

Section: Platelet Indices In Cumentioning

confidence: 99%

The Role of Platelets in Chronic Urticaria

Veña¹,

Cassano

Marzano

et al. 2016

Int Arch Allergy Immunol

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Background: Platelets are implicated in many pathophysiological processes, including inflammation and immunity. Ever-growing evidence suggests the active involvement of platelets in the pathogenesis of various inflammatory disorders, including cutaneous inflammatory diseases. A limited number of studies have investigated the role of platelets in chronic urticaria (CU). In this review, we summarize the current knowledge regarding the role of platelets in chronic spontaneous and inducible urticarias. Methods: A literature search was performed using PubMed and Google Scholar, and the references of relevant literature were reviewed. Results: Overall, in CU patients, conflicting results have been obtained from the assessment of platelet indices, such as mean platelet volume, platelet count and distribution width, as well as markers of platelet aggregation and activation. Nevertheless, a few studies showed significant changes of such parameters in CU patients compared to controls, in apparent correlation with clinical severity, autoreactivity and/or inflammatory status. Conclusions: In the absence of definitive conclusions, the pathogenic role of platelets in CU needs to be further explored. Platelets might represent a link between inflammation, coagulation and histamine release in the pathophysiological network of CU.

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“…This process is manifested by increased concentration of biomarkers—IL-6 and C-reactive protein [2–5], together with activation of the coagulation/fibrinolysis cascade [4, 6, 7], but not blood platelets [8, 9]. Unfortunately, these biomarkers may reflect not only the activity and severity of CU [3, 4], but correlate with a systemic response to infections [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria

et al. 2012

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BackgroundOur previous findings showed the importance of analysing the peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity. However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.AimIn order to investigate a possible association between the immune-inflammatory activation markers CRP and procalcitonin (PCT).MethodsSerum PCT and CRP concentrations were measured in patients with CU of varying severity as well as in healthy subjects.ResultsSerum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP. Serum PCT concentrations remained within normal ranges in most CU patients and were only slightly elevated in some severe CU cases.ConclusionsPCT serum concentration may be only slightly elevated in some cases of severe CU. Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU. PCT should be considered as a better marker than CRP to distinguish between APR to infection and an active non-specific urticarial inflammation.

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Assessment of platelet activity as expressed by plasma levels of platelet factor 4 and β‐thromboglobulin in patients with chronic idiopathic urticaria

Cited by 21 publications

References 29 publications

The Association between Platelet Count and Acute Phase Response in Chronic Spontaneous Urticaria

The Association between Platelet Count and Acute Phase Response in Chronic Spontaneous Urticaria

The Role of Platelets in Chronic Urticaria

Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria

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