The Role of Platelets in Chronic Urticaria

Veña, Gino Antonio; Cassano, Nicoletta; Marzano, Angelo Valerio; Asero, Riccardo

doi:10.1159/000444085

Cited by 22 publications

(28 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…), se ha considerado como un marcador de la activación con cambios en el VPM. 8,9,24 Sin embargo, hasta donde se sabe, aún no se ha investigado la función de los trombocitos en los pacientes con PAIPD. En nuestro estudio, se determinó que el VPM y el VPR en los pacientes con PAIPD estaban significativamente elevados.…”

Section: Discussionunclassified

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

2018

Arch Argent Pediatr

View full text Add to dashboard Cite

RESUMENAntecedentes: Con el incremento de la proctocolitis alérgica inducida por proteínas de la dieta (PAIPD), son necesarios estudios que aclaren su fisiopatología y determinar marcadores no invasivos y sencillos para el diagnóstico y la evaluación del desarrollo de tolerancia. No hallamos estudios publicados sobre la función del índice de neutrófilos/ linfocitos (INL) y el volumen plaquetario medio (VPM), que son marcadores no invasivos fácilmente medibles, en pacientes con PAIPD. Objetivos: Determinar la relación entre el INL y el VPM con el diagnóstico y desarrollo de tolerancia en niños con PAIPD. Métodos: Estudio transversal retrospectivo, los datos se obtuvieron del sistema de registros médicos, los síntomas y los resultados de laboratorio de los pacientes con diagnóstico de PAIPD fueron controlados en los consultorios de alergia y gastroenterología. Se compararon valores del hemograma al momento del diagnóstico con el grupo de niños sanos de edad y sexo similares. Resultados: Entre los 59 pacientes con diagnóstico de PAIPD, los varones representaron el 47,4% y las niñas, el 52,6%. El VPM y el volumen plaquetario relativo (VPR) eran significativamente más altos entre los pacientes con PAIPD en comparación con el grupo de referencia (n: 67) (p < 0,001). Asimismo, VPM y el VPR fueron significativamente elevados en pacientes que no desarrollaron tolerancia comparados con los que la desarrollaron (p= 0,01). Con el INL no hubo diferencias entre los grupos. Conclusiones: El VPM y el VPR se consideraron marcadores adecuados para predecir el pronóstico de los pacientes con PAIPD dado que son rápidos, costo-efectivos y fáciles de medir. Palabras clave: alergia alimentaria, inducida por proteínas, proctocolitis, volumen plaquetario medio, inflamación.

show abstract

Section: Discussionunclassified

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

2018

Arch Argent Pediatr

View full text Add to dashboard Cite

show abstract

“…Despite the fact that coagulation is enhanced in chronic urticaria, the data on the role of platelets in the pathogenesis of CU are limited and conflicting [63]. As blood levels of NO x and nitrate are significantly higher in CSU patients compared to healthy controls, and correlate with disease activity, a pathogenic role of nitrosative stress has been suggested [64].…”

Section: Unraveling Urticariamentioning

confidence: 99%

Recent Advances in Clinical Allergy and Immunology

Simon

2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients’ physical and psychological health, the huge burden they place on patients’ quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as “omics” has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Immense progress has been made in developing and applying novel, targeted therapies, for example for asthma and urticaria. Intensive efforts are being made to find biomarkers that help to classify patients, to identify their potential responsiveness to specific therapies, and to monitor the disease severity. Based on recent insights in the pathogenesis of food allergy and drug hypersensitivity, novel strategies for diagnostics, allergen avoidance, and induction of tolerance have been developed. Here, we summarize important findings in the field of clinical allergy and immunology with a special focus on asthma, allergic rhinitis, atopic dermatitis, food allergy, urticaria, angioedema, and drug hypersensitivity.

show abstract

“…), it has been considered as a marker of activation with MPV changes. 8,9,24 However, as far as we know, the role of platelets in cases with FPIAP has not been investigated, yet. In our study, MPV and PCT values in cases with FPIAP were determined to be significantly high.…”

Section: Platelet a C T I V A T I O N T H A T O C C U R S I N T H E Pmentioning

confidence: 99%

Markers of inflammation and tolerance development in allergic proctocolitis

Nacaroğlu

Erdem

Durgun

et al. 2018

Arch Argent Pediatr

View full text Add to dashboard Cite

Background. Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers. Objectives. The purpose is to determine the relation between NLR and MPV with the diagnosis and development of tolerance in children with FPIAP. Methods. In this retrospective cross-sectional study, clinical, demographic symptoms and laboratory findings of patients, monitored with FPIAP diagnosis in allergy and gastroenterology clinics, were acquired from the patient record system. Hemogram values at the time of diagnosis were compared with the values of healthy children of the same age and gender. Results. Among 59 patients diagnosed with FPIAP, males constitute 47.4% and females constitute 52.6%. MPV and platelet crit (PCT) values were significantly high when compared to the control group (n: 67) in FPIAP cases (p <0.001). Also, MPV and PCT values were significantly high in non-tolerance developing cases when compared to developing ones (p= 0.01). Conclusions. Contrary to NLR, MPV and PCT values have been considered to be good markers in predicting prognosis in cases with FPIAP since they are quick, cost effective and easy to calculate.

show abstract

The Role of Platelets in Chronic Urticaria

Cited by 22 publications

References 87 publications

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

Marcadores de inflamación y desarrollo de tolerancia en la proctocolitis alérgica

Recent Advances in Clinical Allergy and Immunology

Markers of inflammation and tolerance development in allergic proctocolitis

Contact Info

Product

Resources

About