Markers of inflammation and tolerance development in allergic proctocolitis

Nacaroğlu, Hikmet Tekin; Erdem, Semiha Bahçeci; Durgun, Ersin; Karaman, Sait; Erdur, Cahit Barış; Karkmer, Canan S Unsal; Can, Demet

doi:10.5546/aap.2018.eng.e1

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…One was conducted to establish the relationship between neutrophil-to-lymphocyte ratio and MPV with the diagnosis and development of child food protein-induced allergic proctocolitis (FPIAP) tolerance in infants (retrospective cross-sectional) [ 44 ]. Three were conducted for new diagnostic marker parameters for MPV, PDW in appendicitis (2 case-controls and 1 cross-sectional) [ 45 – 47 ].…”

Section: Resultsmentioning

confidence: 99%

A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

2022

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Background Inflammatory bowel disease (IBD) is a chronic gastrointestinal tract inflammatory state, which is affecting millions of individuals in the world. It can affect alimentary canals such as colon, rectum, ileum and other parts. In IBD, platelet parameters underwent several changes. Therefore, the aim of this review was determining the estimated pooled mean platelet volume and mean difference in inflammatory bowel disease to elucidate its potential diagnostic value. Methods Articles were extensively searched in bibliographic databases using Medical Subject Heading and entry phrases or terms. In addition, articles were directly searched in Google Scholar to account for the studies omission in searching bibliographic databases. Observational (cohort, cross-sectional and case-control) studies, published in English language and conducted on IBD were included. For studies meeting the eligibility criteria, the first author’s name, publication year, population, study design, study area, sample size, mean platelet volume and standard deviation were extracted and entered in to Microsoft-excel. The analysis was done by Stata version 11. In order to estimate the pooled mean platelet volume and mean difference, random effect model was done. The heterogeneity was quantified using Higgin’s I2 statistics. Publication bias was determined using Egger’s test statistics and funnel plot. Sub-group analysis based on population carried to reduce heterogeneity. Results A total of 17 relevant articles with 2957 participants (1823 IBD cases and 1134 healthy controls) were included to this study. The pooled estimated MPV was 9.29fl; 95% CI: 9.01–9.57 and 9.50fl; 95% CI: 8.81–10.20 in IBD and control groups, respectively. The standardized pooled estimate of mean difference in mean platelet volume was -0.83fl; 95% CI: -1.15, -0.51; I2: 93.1%; P-value < 0.001. In subgroup analysis based on population, the highest estimated mean difference in MPV was observed among patients of CD; -2.30; 95% CI: -3.46, -1.14; I2: 97.8%; P-value < 0.001. Conclusion According to the current systematic review and meta-analysis, mean platelet volume was lower in IBD compared to control. The decreased mean platelet volume could be attributed to platelet consumption or sequestration associated with the progression of IBD. As a result, in IBD, mean platelet volume can provide diagnostic and prognostic information.

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Section: Resultsmentioning

confidence: 99%

A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

2022

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“…The prevalence of food allergy has increased in recent decades, affecting around 6% of children. [1][2][3][4] Cow's milk protein allergy (CMPA) is the most common cause of food allergy in children, with an estimated prevalence of 1.8-7.5%. 4,5 CMPA may be defined as a reproducible adverse reaction of an immunological nature induced by cow's milk protein.…”

Section: Introductionmentioning

confidence: 99%

“…5 Both IgE and non-IgE mediated CMPA exist. 1,4,5 Typically, IgE-mediated reactions are immediate with a wide spectrum of clinical severity ranging from urticaria to anaphylaxis. Delayed-type reactions are non-IgE-mediated or mixed clinical signs and symptoms involving the gastrointestinal tract (GI), respiratory system or the skin appearing 6-48 hours after ingestion.…”

Section: Introductionmentioning

confidence: 99%

Children with Delayed-Type Cow’s Milk Protein Allergy May Be at a Significant Risk of Developing Immediate Allergic Reactions Upon Re-introduction

Rushood¹,

AL-Qabandi²,

AL-Fadhli³

et al. 2023

JAA

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Background: Cow's Milk Protein Allergy (CMPA) is the most common food allergy in children. The reaction is classified into IgE-mediated immediate reaction and delayed-onset, according to the underlying immune mechanism, and hence, the timing of the symptoms. Case reports suggest that children, with delayed CMPA reactions on elimination diet, may develop severe immediate reactions on reintroduction. Aim: The objective of this study was to evaluate the incidence and the risk factors of developing immediate reactions to milk and dairy products in children with CMPA whose initial presentations were of delayed type. Methods: A retrospective chart review of children, aged 0-12 years, presented with delayed type CMPA reactions to the allergyclinical immunology clinics, was performed. The diagnosis was made clinically, and with appropriate allergy tests when indicated. Results: Sixty children were included. Males:female ratio was 1.7:1. Family history of atopy was in 72%, and 57% had personal history of atopy. Sixty percent were not breast fed. The most common concomitant food allergy was egg. The most common initial presentation was diarrhea without protein loss or bleeding followed by exacerbation of atopic dermatitis upon exposure to dairy products. Immediate reactions developed in 21.6% upon re-exposure. There were significant associations with concomitant food allergy (OR 56.6 (3.15-1016.1) P<0.0001), especially eggs (OR 12.85 (3.09-53.5) P<0.01). Conclusion:Children with CMPA, who present with delayed-type allergic reactions, may be at a significant risk of developing immediate reactions upon reintroduction. Evaluation of possible IgE-mediated allergic reactions before reintroduction may be advisable.

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Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy

Doğan¹,

Sevinç²

2019

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Background Various biomarkers have been investigated in the diagnosis of cow's milk protein allergy (CMPA) in infants. To our knowledge, no prior studies have evaluated serum eosinophil cationic protein (sECP), neutrophil-lymphocyte ratio (NLR), and mean platelet volume (MPV) concurrently in infants with CMPA. Objective To compare sECP levels, MPV, and NLR in infants with and without CMPA, as well as to investigate the suitability of these parameters as biomarkers in the diagnosis of CMPA. Methods Fifty-six children with CMPA were compared to 40 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by a chemiluminescence assay. The MPV values were calculated by devices in hemogram parameters. The NLR values were obtained by dividing the neutrophil count by the lymphocyte count. Results The median sECP level in the CMPA group was significantly higher than in the control group (23.5 and 9.27 ng/mL, respectively; P=0.001). However, there were no significant differences between groups with regards to median MPV (8.5 and 8.6 fL, respectively; P=0.149) and median NLR (0.35 and 0.37 respectively; P=0.637). Correlation analysis of sECP level with MPV and NLR in the CMPA group revealed no significant relationships (P>0.05 for both). In the Receiver-operating characteristic (ROC) curve analysis, the optimal cut-off levels to identify CMPA for sECP, MPV, and NLR were 18.4 ng/mL (60.7% sensitivity, 97.5% specificity, and AUC: 0.831), 10.05 fL (54% sensitivity, 77.5% specificity, and AUC: 0.413) and 0.97 (14.3% sensitivity, 50% specificity, and AUC: 0.528), respectively. Conclusions The sECP level and blood eosinophil count are significantly higher in infants with CMPA, but MPV and NLR do not differ between infants with and without CMPA. There are also no significant correlations in the CMPA group between sECP and MPV, as well as sECP and NLR. Serum ECP might be useful as a potential biomarker for diagnosing CMPA.

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Markers of inflammation and tolerance development in allergic proctocolitis

Cited by 5 publications

References 18 publications

A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

A mean platelet volume in inflammatory bowel disease: A systematic review and meta-analysis

Children with Delayed-Type Cow’s Milk Protein Allergy May Be at a Significant Risk of Developing Immediate Allergic Reactions Upon Re-introduction

Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy

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