Assessment of Posterior Segment Using Spectral Domain OCT in Highly Myopic Eyes

AttaAllah, Heba Radi; Omar, Ismail Ahmed Nagib; Abdelhalim, Ahmed Shawkat

doi:10.2174/1874364101711010334

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…Several reports suggest that the disruption or decreased reflectivity of the ellipsoid zone is one of the OCT characteristics of HM [ 15 , 32 ]. The loss of the interdigitation zone was also thought to be the evidence of overlying photoreceptor degeneration [ 33 , 34 ]. Circumscribed loss of outer foveal layer is observed in various diseases such as geographic atrophy and choroideremia [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Scleral Contour Changes in High Myopia by Optical Coherence Tomography

Shin

Kang

Kim

et al. 2022

Korean J Ophthalmol

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Purpose: This study aimed to establish and validate optical coherence tomography (OCT) based diagnostic criteria of high myopia.Methods: This was a cross-sectional study including 100 eyes of high myopia with axial length larger than 26.5 mm and 100 control eyes, which were examined by spectral-domain OCT. Vertical and horizontal OCT of 9 mm scanning across fovea were analyzed. OCT characteristics including mirror artifact, scleral sink due to steep inclination of posterior sclera, scleral visibility, abnormality of outer retinal layer, foveoschisis, and dome-shaped macula were assessed in each group.Results: The mean axial length was 28.65 ± 2.07 mm (range, 26.51–34.59 mm) in high myopia group and 23.79 ± 0.99 mm (range, 21.26–25.94 mm) in control group. Among the OCT characteristics noted at high frequency in the eyes with high myopia, three criteria achieving high sensitivity and specificity were determined: scleral sink over 500 μm, scleral visibility over 100 μm, and dome-shaped macula. Under conditions of presence of any of three criteria in either horizontal or vertical OCT scanning, the diagnostic sensitivity, specificity, positive predictive value, and negative predictive value for high myopia were found to be 95.0%, 98.0%, 98.0%, and 95.1%, respectively. In a new set of OCT images from 50 eyes with high myopia and 50 eyes of nonhigh myopia cases, the OCT-based criteria also proved similar level of diagnostic validity.Conclusions: The OCT-based criteria, which directly addressed posterior scleral contour changes, may lead to an intuitive and accurate diagnosis of high myopia. Also, the criteria may contribute to early detection and monitoring of eyes that cannot be defined as high myopia but can progress. OCT may be useful for monitoring high myopia patients as OCT can detect myopia-associated retinal pathologies as well as scleral contour changes.

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Section: Discussionmentioning

confidence: 99%

Assessment of Scleral Contour Changes in High Myopia by Optical Coherence Tomography

Shin

Kang

Kim

et al. 2022

Korean J Ophthalmol

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“…The ILM is composed of the vitreous-facing endfoot membranes of Müller cells and the basal lamina at the inner retinal surface. ILM detachment is often found in highly myopic eyes; the schisis between the ILM and NFL is vertically traversed by Müller cell trunks; the latter differentiates the detached ILM from the posterior vitreous and idiopathic epiretinal membranes (ERM) [8,[13][14][15][16][17][18][19] . ILM detachment is also often a component of glaucomatous peripapillary retinoschisis [20] .…”

Section: Foveal Regeneration After Cmementioning

confidence: 99%

Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment: presumed role of glial cells for foveal structure stabilization

et al. 2021

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AIM: To document with spectral-domain optical coherence tomography the morphological regeneration of the fovea after resolution of cystoid macular edema (CME) without and with internal limiting membrane (ILM) detachment and to discuss the presumed role of the glial scaffold for foveal structure stabilization. METHODS: A retrospective case series of 38 eyes of 35 patients is described. Of these, 17 eyes of 16 patients displayed foveal regeneration after resolution of CME, and 6 eyes of 6 patients displayed CME with ILM detachment. Eleven eyes of 9 patients displayed other kinds of foveal and retinal disorders associated with ILM detachment. RESULTS: The pattern of edematous cyst distribution, with or without a large cyst in the foveola and preferred location of cysts in the inner nuclear layer or Henle fiber layer (HFL), may vary between different eyes with CME or in one eye during different CME episodes. Large cysts in the foveola may be associated with a tractional elevation of the inner foveal layers and the formation of a foveoschisis in the HFL. Edematous cysts are usually not formed in the ganglion cell layer. Eyes with CME and ILM detachment display a schisis between the detached ILM and nerve fiber layer (NFL) which is traversed by Müller cell trunks. ILM detachment was also found in single eyes with myopic traction maculopathy, macular pucker, full-thickness macular holes, outer lamellar holes, and glaucomatous parapapillary retinoschisis, and in 3 eyes with Müller cell sheen dystrophy (MCSD). As observed in eyes with MCSD, cellophane maculopathy, and macular pucker, respectively, fundus light reflections can be caused by different highly reflective membranes or layers: the thickened and tightened ILM which may or may not be detached from the NFL, the NFL, or idiopathic epiretinal membranes. In eyes with short single or multiple CME episodes, the central fovea regenerated either completely, which included the disappearance of irregularities of the photoreceptor layer lines and the reformation of a fovea externa, or with remaining irregularities of the photoreceptor layer lines. CONCLUSION: The examples of a complete regeneration of the foveal morphology after transient CME show that the fovea may withstand even large tractional deformations and has a conspicuous capacity of structural regeneration as long as no cell degeneration occurs. It is suggested that the regenerative capacity depends on the integrity of the threedimensional glial scaffold for foveal structure stabilization composed of Müller cell and astrocyte processes. The glial scaffold may also maintain the retinal structure after loss of most retinal neurons as in late-stage MCSD.

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“…Структурні особливості сітківки в макулярній та перипапілярній ділянках очного дна досить добре вивчені як при прогресуючій, так і при високій ускладненій міопії [1,3]. Багато праць присвячено вивченню морфометричних змін сітківки при змінах топографії макули, зумовленої формуванням задньої міопічної стафіломи [8].…”

Section: морфометричні особливості судинної оболонки ока у пацієнтів ...unclassified

Морфометричні Особливості Судинної Оболонки Ока У Пацієнтів З Прогресуючою Міопією За Даними Ss-Оптичної Когерентної Томографії-Ангіографії

Ulyanova¹,

Burdeinyi²

2021

AOU

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Метою дослідження було вивчення морфометричних змін судинної оболонки у задньому сегменті ока у пацієнтів з прогресуючою міопією за даними Swept Sourсe-оптичної когерентної томографії-ангіографії (SS-ОКТА). Під спостереженням знаходились 50 пацієнтів (100 очей) з різними темпами прогресування міопії та 20 здорових дітей (40 очей) з еметропією.У пацієнтів зі швидким прогресуванням міопії виявлено збільшення товщини сітківки в центрі фовеа порівняно з еметропами та зменшення товщини хоріоідеї в центрі фовеа і у папіломакулярній ділянці порівняно як із еметропами, так і з міопами з повільним прогресуванням міопії. При прогресуванні міопії встановлено нерівномірне зменшення товщини хоріоідеї, яке проявляється у достовірному збільшенні ретинально-хоріоідального коефіцієнта на ділянці між центром фовеа та диском зорового нерва, що у комплексі морфологічних змін заднього сегмента міопічного ока може сприяти розвитку регіонарних гемодинамічних порушень.

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Assessment of Posterior Segment Using Spectral Domain OCT in Highly Myopic Eyes

Cited by 10 publications

References 35 publications

Assessment of Scleral Contour Changes in High Myopia by Optical Coherence Tomography

Assessment of Scleral Contour Changes in High Myopia by Optical Coherence Tomography

Foveal regeneration after resolution of cystoid macular edema without and with internal limiting membrane detachment: presumed role of glial cells for foveal structure stabilization

Морфометричні Особливості Судинної Оболонки Ока У Пацієнтів З Прогресуючою Міопією За Даними Ss-Оптичної Когерентної Томографії-Ангіографії

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