Assessment of pressure-volume relations in univentricular hearts: Comparison of obtainment by real-time 3D echocardiography and mini pressure-wire with conductance technology

Abstract

Objectives The gold standard to obtain pressure-volume relations (PVR) of the heart, the conductance technology (PVRCond), is rarely used in children. PVR can also be obtained by 3D-echocardiography volume data combined with simultaneously measured pressure data by a mini pressure-wire (PVR3DE). We sought to investigate the feasibility of both methods in patients with univentricular hearts and to compare them, including hemodynamic changes. Methods We studied 19 patients (age 2–29 years). PVR3DE and PVRCond were assessed under baseline conditions and stimulation with dobutamine. Results Obtaining PVR3DE was successful in all patients. Obtaining PVRCond was possible in 15 patients during baseline (79%) and in 12 patients under dobutamine (63%). Both methods showed that end-systolic elastance (Ees) and arterial elastance (Ea) increased under dobutamine and that Tau showed a statistically significant decrease. Intraclass correlation (95% confidence interval) showed moderate to good agreement between methods: Ees: 0.873 (0.711–0.945), Ea: 0.709 (0.336–0.873), Tau: 0.867 (0.697–0.942). Bland-Altman analyses showed an acceptable bias with wider limits of agreement: Ees: 1.63 mmHg/ml (-3.83–7.08 mmHg/ml), Ea: 0.53 mmHg/ml (-5.23–6.28 mmHg/ml), Tau: -0,76 ms (-10.73–9.21 ms). Conclusion Changes of PVR-specific parameters under dobutamine stimulation were reflected in the same way by both methods. However, the absolute values for these parameters could vary between methods and, therefore, methods are not interchangeable. Obtaining PVR3DE in a single ventricle was easier, faster and more successful than PVRCond. PVR3DE provides a promising and needed alternative to the conductance technology for the assessment of cardiac function in univentricular hearts.

Intraventricular Flow Simulations in Singular Right Ventricles Reveal Deteriorated Washout and Low Vortex Formation

“…and represent different ages, end-diastolic volumes (EDV), and ejection fractions (EF). 19 The LV patients were selected from Krell et al . and represent small (pediatric) ventricles with EDV 40–60 mL.…”

“…These curves were taken from clinical data of UKB (see Linden et al . 19 ). The pressure curves for the healthy LV have been calculated via a lumped parameter model (LPM) of the UKB.…”

“…The SRV group was selected from data of Linden et al and represent different ages, end-diastolic volumes (EDV), and ejection fractions (EF). 19 The LV patients were selected from Krell et al and represent small (pediatric) ventricles with EDV 40-60 mL. 14 Table 1 summarizes the patient data used in this study.…”

“…As inlet and outlet conditions, patient specific pressure curves were set as boundary conditions for the SRV patients. These curves were taken from clinical data of UKB (see Linden et al 19 ). The pressure curves for the healthy LV have been calculated via a lumped parameter model (LPM) of the UKB.…”