Assessment of probiotic efficacy and anticancer activities of Lactiplantibacillus plantarum ESSG1 (MZ683194.1) and Lactiplantibacillus pentosus ESSG2 (MZ683195.1) isolated from dairy products

Ellatif, Sawsan Abd; Bouqellah, Nahla A.; Abu‐Serie, Marwa M.; Razik, Elsayed S. Abdel; AL-surhanee, Ameena A.; Askary, Ahmad El; Daigham, Ghadir E.; Mahfouz, Amira Yahia

doi:10.1007/s11356-022-18537-z

Cited by 7 publications

(2 citation statements)

References 85 publications

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“…The antifungal potential of LAB strains was also estimated, and our results showed that LAB inhibit the growth of P. expansum, A. niger, F. culmorum, and B. cinerea. These findings are similar to the work carried out by other investigators [92,93]. A recent Turkish publication [94] showed that Lpb.…”

Section: Discussionsupporting

confidence: 91%

Lactiplantibacillus plantarum from Unexplored Tunisian Ecological Niches: Antimicrobial Potential, Probiotic and Food Applications

Selmi,

Rocchetti,

Capozzi

et al. 2023

Microorganisms

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The continued exploration of the diversity of lactic acid bacteria in little-studied ecological niches represents a fundamental activity to understand the diffusion and biotechnological significance of this heterogeneous class of prokaryotes. In this study, Lactiplantibacillus plantarum (Lpb. plantarum) strains were isolated from Tunisian vegetable sources, including fermented olive and fermented pepper, and from dead locust intestines, which were subsequently evaluated for their antimicrobial activity against foodborne pathogenic bacteria, including Escherichia coli O157:H7 CECT 4267 and Listeria monocytogenes CECT 4031, as well as against some fungi, including Penicillium expansum, Aspergilus niger, and Botrytis cinerea. In addition, their resistance to oro-gastro-intestinal transit, aggregation capabilities, biofilm production capacity, adhesion to human enterocyte-like cells, and cytotoxicity to colorectal adenocarcinoma cell line were determined. Further, adhesion to tomatoes and the biocontrol potential of this model food matrix were analyzed. It was found that all the strains were able to inhibit the indicator growth, mostly through organic acid production. Furthermore, these strains showed promising probiotic traits, including in vitro tolerance to oro-gastrointestinal conditions, and adhesion to abiotic surfaces and Caco-2 cells. Moreover, all tested Lpb. plantarum strains were able to adhere to tomatoes with similar rates (4.0–6.0 LogCFU/g tomato). The co-culture of LAB strains with pathogens on tomatoes showed that Lpb. plantarum could be a good candidate to control pathogen growth. Nonetheless, further studies are needed to guarantee their use as probiotic strains for biocontrol on food matrices.

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Section: Discussionsupporting

confidence: 91%

Lactiplantibacillus plantarum from Unexplored Tunisian Ecological Niches: Antimicrobial Potential, Probiotic and Food Applications

Selmi,

Rocchetti,

Capozzi

et al. 2023

Microorganisms

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show abstract

“…L. plantarum is identified to restore the intestinal mucosal barrier ( 5 ), regulate dysbacteriosis, reduce inflammation, and alleviate inflammatory bowel disease ( 6 , 7 ). Moreover, L. plantarum has antimicrobial, antioxidant, and anticancer potential ( 8 ). The advances in multi-omics have led to probiogenomics, an approach to identify genetic markers that facilitate the adaptation of a probiotic to human gut ( 9 , 10 ).…”

Section: Announcementmentioning

confidence: 99%

Draft genome sequence of Lactiplantibacillus plantarum subsp. plantarum strain HF43, a human gut-associated potential probiotic

Idrees

Atiq

Zahra

et al. 2023

Microbiol Resour Announc

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Lactiplantibacillus plantarum adapts to a wide range of ecological niches, including the human gut. Numerous health-promoting benefits have been associated with L . plantarum strains. Motivated for the development of human-origin target-based probiotics with known genetic markers, we report the draft genome sequence of human gut-associated Lactiplantibacillus plantarum subsp. plantarum HF43.

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Biological activities and ecological aspects of Limonium pruinosum (L.) collected from Wadi Hof Eastern Desert, Egypt, as a promising attempt for potential medical applications

Sultan¹,

Bedair²,

Ragab³

et al. 2023

Biomass Conv. Bioref.

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Very few researchers have focused on the biological efficacy of Limonium plants. In this concern, no investigations were commenced to delve into the in vitro and ex vivo biological actions of Limonium pruinosum in Egypt. Therefore, this work aims to assess for the first time the antimicrobial, antioxidant, and antitumor activities of Limonium pruinosum extract in addition to studying its ability to suppress the transcription of cell cycle–stimulating genes. L. pruinosum ethyl acetate extract exhibits considerable antibacterial and antibiofilm activity versus E. coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Results revealed that L. pruinosum exerts antioxidant effectiveness concerning DPPH, nitric oxide (NO), and hydroxyl radical (OH) scavenging ability with an IC50 (35.88 ± 2.2, 51.31 ± 1.06, and 65.87 ± 1.19 μg/mL) respectively. The results proved the effectiveness of L. pruinosum in closing wounds in gastric epithelial cells (GES-1) by (79.9343 ± 1.98%) compared with control (68.3637 ± 2.32%) in 48 h. Additionally, L. pruinosum had anticancer activity contrary to breast cancer MCF-7 and liver cancer HepG-2 cell lines with IC50 values of 96.73 ± 2.18 and 81.81 ± 0.99 μg/mL, respectively, while it had no cytotoxic activity against (Wi-38) normal cells. Also, L. pruinosum extract provoked considerable early- and late-apoptotic cell populations and was effective in inducing cell death of MCF-7. Our findings evoked that L. pruinosum has promising antibacterial, antioxidant, and wound healing activities and a good breast tumor suppressor arresting the cell cycle-stimulating genes, which may be an auspicious approach for the treatment of breast cancer.

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Assessment of probiotic efficacy and anticancer activities of Lactiplantibacillus plantarum ESSG1 (MZ683194.1) and Lactiplantibacillus pentosus ESSG2 (MZ683195.1) isolated from dairy products

Cited by 7 publications

References 85 publications

Lactiplantibacillus plantarum from Unexplored Tunisian Ecological Niches: Antimicrobial Potential, Probiotic and Food Applications

Lactiplantibacillus plantarum from Unexplored Tunisian Ecological Niches: Antimicrobial Potential, Probiotic and Food Applications

Draft genome sequence of Lactiplantibacillus plantarum subsp. plantarum strain HF43, a human gut-associated potential probiotic

Biological activities and ecological aspects of Limonium pruinosum (L.) collected from Wadi Hof Eastern Desert, Egypt, as a promising attempt for potential medical applications

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