INTRODUCTIONThe number of opioid-related overdose deaths has increased concurrently with rising rates of opioid use nationally. 1 Clinical encounters offer an opportunity to provide high-risk patients with targeted interventions, 2 yet clinicians routinely miss the opportunity to deliver risk reduction counseling and naloxone to appropriate patients 3 due, in part, to knowledge gaps. 4,5 To better identify physician education targets, we examined how internal medicine trainees' beliefs influence willingness to prescribe naloxone, how residents assess risk of opioidrelated overdose, and concordance between risk assessment and naloxone prescription.
METHODSThe study occurred at an academic medical center in Baltimore, MD, with high rates of opioid use and overdose. IRB deemed our study exempt. We surveyed internal medicine residents and collected information on beliefs and behaviors based on seven clinical vignettes. Each vignette provided patient-specific information including age, medical comorbidities, type, and quantity of opioids, and if opioids were chronically or acutely prescribed. Vignettes incorporated a range of overdose risk factors discussed in the literature: opioid dose > 50-100 morphine milligram equivalents (MME) per day confer a moderate risk, dose > 100 MME/day confer a high risk; presence of co-occurring substance use and history of previous overdose both increase risk of overdose compared to those without similar risk factors. 1 We asked residents the likelihood of overdose risk on a four-point scale (not likely, low, medium, or high) and if they would prescribe naloxone.We completed bivariate analyses looking at relationship of provider characteristics, history of having prescribed naloxone, and willingness to prescribe in the future using STATA (v.15.0, StataCorp). To analyze clinical vignettes, we collapsed risk assessment as determined by the residents into two categories of overdose likelihood: not likely/low and moderate/high. We defined discordant prescribing as occurring when residents rated patients as not likely or low risk of opioid overdose, but still prescribed naloxone and when residents rated patients as moderate to high risk but, did not prescribe naloxone.
RESULTSThe survey response rate was 68% (N = 97), divided evenly among all training years. Beliefs increasing the willingness to prescribe naloxone included positive attitudes on addiction education and believing naloxone is effective in reducing overdose (Table 1). Physician demographic factors were not associated with willingness to prescribe naloxone including age (OR 0.83; 95%CI 0.65, 1.07); gender (OR 0.68; 95%CI 0.20, 2.26); race (OR 0.28; 95%CI 0.46, 3.62); or year of training (OR 0.74, 95%CI 0.38, 1.53). Having prescribed naloxone in the past did not increase the residents' likelihood of prescribing naloxone in these vignettes (OR 0.85; 95%CI − 0.16, 4.39).