Assessment of pulmonary artery pulse wave velocity in children: An MRI pilot study

Poon, Chuen; Edwards, James; Evans, John; Harris, Ashley D.; Tsai-Goodman, Beverly; Bolton, Charlotte E.; Cockcroft, John R.; Wise, Richard G.; Kotecha, Sailesh

doi:10.1016/j.mri.2013.08.006

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Manual outlining of the PA was undertaken in our study. Although this can be subjective, we have reported good repeatability and low variability;14 a robust, automated vessel outlining tool based on active contouring could possibly minimise operator-related manual errors.…”

Section: Discussionmentioning

confidence: 84%

“…of acquired phases between 35 and 58 phases depending on heart rate, V enc =150 cm/s, acquisition matrix=192×192, field of view=350 mm and flip angle=20°. The MRI examination was performed, as previously reported,14 under free breathing conditions with instructions to maintain shallow breathing during image acquisition to minimise translational movement of the heart associated with respiration and to obtain normal physiological PA blood flow. Using this technique, we have previously reported good intra-observer and inter-observer repeatability with coefficient of variations 9% and 15.6%, respectively 14…”

Section: Methodsmentioning

confidence: 99%

“…Our previous studies established the feasibility and safety of using hypoxic mixture of 15% and 12% oxygen in similarly aged children 7 14. Premixed cylinders of 12% oxygen/nitrogen mixture and 100% oxygen were obtained from British Oxygen Company (Port Talbot).…”

Section: Methodsmentioning

confidence: 99%

“…Flow rate was plotted against measured cross sectional area of the PA during early systole using the data generated by the software. The PWV was derived from the slope of the line fitted to the flow-area data, which represents the ratio of flow change (ΔQ) and area change (ΔA) during early systole13 14 (figure 1). …”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity

Poon

Watkins

Evans

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity

Poon

Watkins

Evans

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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“…CT and MRI only provide limited assessment of pulmonary haemodynamics,29 and changes in global RV function, such as ejection fraction, are uninformative about preclinical disease although velocity-encoded phase-contrast MRI seems to be promising in our preliminary study 30. We also used myocardial velocity imaging because it allows accurate assessment of regional myocardial function.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular function in children who had chronic lung disease of prematurity

Joshi

Wilson

Kotecha

et al. 2014

Arch Dis Child Fetal Neonatal Ed

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Feasibility, Repeatability, and Correlation to Lung Function of Phase‐Resolved Functional Lung (PREFUL) MRI‐derived Pulmonary Artery Pulse Wave Velocity Measurements

Wernz,

Voskrebenzev,

Müller

et al. 2024

Magnetic Resonance Imaging

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BackgroundPulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase‐contrast (PC) MRI‐based options exist to measure PA‐PWV.PurposeTo test feasibility, repeatability, and correlation to clinical data of Phase‐Resolved Functional Lung (PREFUL) MRI‐based calculation of PA‐PWV.Study TypeRetrospective.Subjects79 (26 female) healthy subjects (age range 19–78), 58 (24 female) patients with chronic obstructive pulmonary disease (COPD, age range 40–77), 60 (33 female) patients with suspected pulmonary hypertension (PH, age range 28–85).Sequence2D spoiled gradient echo, 1.5T.AssessmentPA‐PWV was measured from PREFUL‐derived cardiac cycles based on the determination of temporal and spatial distance between lung vasculature voxels using a simplified (sPWV) method and a more comprehensive (cPWV) method including more elaborate distance calculation. For 135 individuals, PC MRI‐based PWV (PWV‐QA) was measured.Statistical TestsIntraclass‐correlation‐coefficient (ICC) and coefficient of variation (CoV) were used to test repeatability. Nonparametric tests were used to compare cohorts. Correlation of sPWV/cPWV, PWV‐QA, forced expiratory volume in 1 sec (FEV1) %predicted, residual volume (RV) %predicted, age, and right heart catheterization (RHC) data were tested. Significance level α = 0.05 was used.ResultssPWV and cPWV showed no significant differences between repeated measurements (P‐range 0.10–0.92). CoV was generally lower than 15%. COPD and PH patients had significantly higher sPWV and cPWV than healthy subjects. Significant correlation was found between sPWV or cPWV and FEV1%pred. (R = −0.36 and R = −0.44), but not with RHC (P‐range −0.11 − 0.91) or age (P‐range 0.23–0.89). Correlation to RV%pred. was significant for cPWV (R = 0.42) but not for sPWV (R = 0.34, P = 0.055). For all cohorts, sPWV and cPWV were significantly correlated with PWV‐QA (R = −0.41 and R = 0.48).Data ConclusionPREFUL‐derived PWV is feasible and repeatable. PWV is increased in COPD and PH patients and correlates to airway obstruction and hyperinflation.Level of Evidence3Technical EfficacyStage 2

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Assessment of pulmonary artery pulse wave velocity in children: An MRI pilot study

Cited by 10 publications

References 16 publications

Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity

Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity

Cardiovascular function in children who had chronic lung disease of prematurity

Feasibility, Repeatability, and Correlation to Lung Function of Phase‐Resolved Functional Lung (PREFUL) MRI‐derived Pulmonary Artery Pulse Wave Velocity Measurements

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