Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production

Marengo, Mario; Lodi, Filippo; Magi, Silvia; Cicoria, Gianfranco; Pancaldi, D.; Boschi, Stefano

doi:10.1016/j.apradiso.2007.08.015

Cited by 43 publications

(34 citation statements)

References 7 publications

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“…10 % retained in anionite and this could be explained by trapping in the form of the Co(OH) 4 -complex. The same ratio was observed in [14] and [9]. Due to their lability, cobalt nuclides were slightly eluted from the anionic column and traces were found in the later synthesis stages.…”

Section: Resultssupporting

confidence: 77%

“…51 C was determined both in the recovery water and the QMA column, since chromium can exist both as a Cr(III) cation travelling with H 2 18 O water and a Cr(VI) anion retained in the QMA column. This promotes the diversity in distribution observed in [9] where the 51 Cr activity was highest in the QMA column, which meant that the predominant form was Cr(VI); in [14,15] it was roughly balanced but in [15] significant activity was found in the waste, which has not been confirmed by other studies. 52 Mn was observed in all elements.…”

Section: Resultsmentioning

confidence: 64%

“…The 56 Co isotope was observed in the final product, but the activity was too small for quantification. Some ambiguities arose for 55 Co, which was observed by some authors [8,9,14,16]. The measured activities are highly variable and the distribution between the anionic and cationic form varies, compared to the other cobalt isotopes.…”

Section: Resultsmentioning

confidence: 89%

“…Therefore, only samples that were measured after a sufficiently short time were identified and accurately determined. The most consistent data concerning 55 Co were presented in [14], where the samples were measured 24 h after synthesis. 57 Ni was only found in the enriched water and migrates in cationic form.…”

Section: Resultsmentioning

confidence: 98%

“…This distribution is confirmed by other cited papers. 56,57,58 Co isotopes make the greatest contribution to the activity due to radionuclidic impurities [7][8][9][11][12][13][14][15]. 56 Co and 57 Co radionuclides were approx.…”

Section: Resultsmentioning

confidence: 99%

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Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Kilian

Pęgier

Pękal

et al. 2015

J Radioanal Nucl Chem

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In this study the identification, determination and distribution of metallic and radionuclidic contaminants in the synthesis of 18 F-fluorodeoxyglucose are presented. Samples of irradiated 18 O-enriched water, purification columns (anionic, C18, Al 2 O 3 ), final product and wastes were examined. Metallic contaminants were determined by ICP-MS and the radionuclide impurities by high resolution germanium gamma-spectrometry. Fifteen radionuclides were identified in the samples. The enriched water contained cationic contaminants ( 55 Co, 56 Co, 57 Co, 58 Co, 57 Ni, 52 Mn, 7 Be) while the anionic ( 95 Tc, 95m Tc, 96 Tc, 183 Re) were mostly retained in the QMA column. The sources of contamination by metals and radionuclides were determined. Results obtained by ICP-MS generally confirmed the radionuclide distribution obtained by gamma spectrometry.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Kilian

Pęgier

Pękal

et al. 2015

J Radioanal Nucl Chem

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Diagnostic Imaging Agents

Bohrer

2012

Sources of Contamination in Medicinal Products and Medical Devices

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Pre‐discard estimation of radioactivated materials in positron emission tomography cyclotron systems and concrete walls of a cyclotron vault

Wagatsuma

Ishiwata

Nobuhara³

et al. 2019

Medical Physics

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Purpose The concrete vault, cyclotron body, and peripheral equipment in a cyclotron room become radioactivated by neutrons generated by operating an unshielded cyclotron. Radionuclides and the amounts of radioactivated materials must be identified before discarding a cyclotron system. The present study aimed to reduce the amounts of concrete from cyclotron vaults, as well as cyclotron components and peripheral equipment, that will be disposed of as radioactivated waste by clarifying the nature and quantity of radioactivated materials remaining in facilities after cyclotron operations have ceased. Methods Cylindrical concrete cores were bored into all four walls, ceiling, and floor of a room where a Cypris 370 cyclotron had been operated for 22.8 yr and then cooled for 40 months. The accelerated particles comprised protons and deuterons with constant energy of 18 and 10 MeV, respectively. The types and amounts of radionuclides in these cores, in 38 components of the cyclotron including the yoke, and in 13 pieces of equipment in the room, were determined by γ‐ray spectrometry. Concentrations of radioactivity were also calculated using an updated version of Particle and Heavy Ion Transport System and DCHAIN‐SP. Amounts of materials with both measured and calculated total radioactivity concentration (ΣD) of <0.1 Bq/g were identified as being nonradioactivated. Results The major radionuclides in the concrete were 60Co and 152Eu. The radioactivated concrete was distributed to a depth of <38 cm. Most cyclotron components and equipment were radioactivated by neutrons. The major radionuclides in cyclotron components and equipment were 54Mn, 60Co, and 65Zn. A 33% volume of the yoke was regarded as nonradioactivated. Conclusions The estimated amount of radioactivated waste in the concrete was about 70,000 kg (12.5% of the total concrete). Most components of the cyclotron except for the 33% volume of the yoke (20% of the cyclotron body), as well as most peripheral equipment in the room, were radioactivated. Part‐by‐part assessments of radioactive materials using measurements and calculations could distinguish nonradioactive from radioactive materials before they are discarded.

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Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production

Cited by 43 publications

References 7 publications

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Distribution and separation of metallic and radionuclidic impurities in the production of 18F-fluorodeoxyglucose

Diagnostic Imaging Agents

Pre‐discard estimation of radioactivated materials in positron emission tomography cyclotron systems and concrete walls of a cyclotron vault

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