Assessment of Regional Lung Function with Multivolume<sup>1</sup>H MR Imaging in Health and Obstructive Lung Disease: Comparison with<sup>3</sup>He MR Imaging

Pennati, Francesca; Quirk, James D.; Yablonskiy, Dmitriy A.; Castro, Mario; Aliverti, Andréa; Woods, Jason C.

doi:10.1148/radiol.14132470

Cited by 43 publications

(72 citation statements)

References 41 publications

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“…While this technique using CT has been shown to be exquisitely sensitive to regional variation, concern over exposure to ionizing radiation makes serial imaging with CT impractical, particularly for vulnerable populations [49,50]. Multivolume MR imaging has recently been developed as a potential surrogate for assessing ventilation inhomogeneity due to gravitational dependence and regional abnormalities caused by lung disease [46]. One advantage of gated MR imaging is that patients can freely breathe during a scan; through a technique of either prospective or retrospective gating, images at inspiration and expiration can be utilized for ventilation mapping [51].…”

Section: Introductionmentioning

confidence: 99%

Using imaging as a biomarker for asthma

Trivedi

Hall

Hoffman

et al. 2017

Journal of Allergy and Clinical Immunology

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There have been significant advancements in the various imaging techniques that are being used in the evaluation of patients with asthma, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements by CT correlate with clinical parameters including severity of disease and pathology but also provide unique phenotypes. Hyperpolarized 129Xe and 3He are gases used as contrast media for MRI that provide measurement of distal lung ventilation reflecting small airway disease. PET scanning can be useful to identify and target lung inflammation in asthma. Furthermore, imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty.

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Section: Introductionmentioning

confidence: 99%

Using imaging as a biomarker for asthma

Trivedi

Hall

Hoffman

et al. 2017

Journal of Allergy and Clinical Immunology

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“…Importantly, this method was recently shown in COPD subjects with emphysema 122 and contrast can be generated using static volumetric 1 H MRI methods. 123 Figure 5 shows very recent examples of Fourier-decomposition of pulmonary magnetic resonance imaging (FDMRI) in COPD subjects across GOLD grades and excellent comparisons were also shown in animal studies. 124 FDMRI exploits free-breathing 1H MRI and non-rigid registration to generate ventilation images.…”

Section: Pulmonary Mri Measurements Of Copdmentioning

confidence: 88%

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

Hoffman

Lynch

Barr

et al. 2015

Magnetic Resonance Imaging

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Pulmonary X-ray computed tomographic (CT) and magnetic resonance imaging (MRI) research and development has been motivated, in part, by the quest to sub-phenotype common chronic lung diseases such as chronic obstructive pulmonary disease (COPD). For thoracic CT and MRI, the main COPD research tools, disease biomarkers are being validated that go beyond anatomy and structure to include pulmonary functional measurements such as regional ventilation, perfusion and inflammation. In addition, there has also been a drive to improve spatial and contrast resolution while at the same time reducing or eliminating radiation exposure. Therefore, this review focuses on our evolving understanding of patient-relevant and clinically-important COPD endpoints and how current and emerging MRI and CT tools and measurements may be exploited for their identification, quantification and utilization. Since reviews of the imaging physics of pulmonary CT and MRI and reviews of other COPD imaging methods were previously published and well-summarized, we focus on the current clinical challenges in COPD and the potential of newly emerging MR and CT imaging measurements to address them. Here we summarize MRI and CT imaging methods and their clinical translation for generating reproducible and sensitive measurements of COPD related to pulmonary ventilation and perfusion as well as parenchyma morphology. The key clinical problems in COPD provide an important framework in which pulmonary imaging needs to rapidly move in order to address the staggering burden, costs as well as the mortality and morbidity associated with COPD.

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“…With motion navigators derived from the radial trajectory, it is potentially feasible to retrospectively reconstruct images not only to reduce bulk motion, but at multiple lung inflation volumes throughout the respiratory cycle . This could allow quantification of tidal lung volumes and regional changes in parenchymal density as a function of lung volume, potentially providing local compliance measures relative to ventilation …”

Section: Discussionmentioning

confidence: 99%

Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system

Hahn

Higano

Walkup

et al. 2016

J. Magn. Reson. Imaging

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Purpose To determine feasibility of pulmonary MRI of neonatal lung structures enabled by combining two novel technologies: first, a 3D radial ultrashort echo time (UTE) pulse sequence capable of high spatial resolution full-chest imaging in non-sedated quiet-breathing neonates, and second, a unique, small-footprint 1.5T MRI scanner design adapted for neonatal imaging and installed within the Neonatal Intensive Care Unit (NICU). Materials and Methods Ten patients underwent MRI within the NICU, in accordance with an approved Institutional Review Board protocol. Five had clinical diagnoses of bronchopulmonary dysplasia (BPD), and five had putatively normal lung function. Pulmonary imaging was performed at 1.5T using 3D radial UTE and standard 3D fast gradient recalled echo (FGRE). Diagnostic quality, presence of motion artifacts, and apparent severity of lung pathology were evaluated by two radiologists. Quantitative metrics were additionally used to evaluate lung parenchymal signal. Results UTE images showed significantly higher signal in lung parenchyma (p <0.0001) and fewer apparent motion artifacts compared to FGRE (p = 0.046). Pulmonary pathology was more severe in patients diagnosed with BPD relative to controls (p = 0.001). Infants diagnosed with BPD also had significantly higher signal in lung parenchyma, measured using UTE, relative to controls (p = 0.002). Conclusion These results demonstrate the technical feasibility of pulmonary MRI in free-breathing, non-sedated infants in the NICU at high, isotropic resolutions approaching that achievable with CT. There is potential for pulmonary MRI to play a role in improving how clinicians understand and manage care of neonatal and pediatric pulmonary diseases.

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Assessment of Regional Lung Function with Multivolume¹H MR Imaging in Health and Obstructive Lung Disease: Comparison with³He MR Imaging

Cited by 43 publications

References 41 publications

Using imaging as a biomarker for asthma

Using imaging as a biomarker for asthma

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system

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Assessment of Regional Lung Function with Multivolume1H MR Imaging in Health and Obstructive Lung Disease: Comparison with3He MR Imaging

Cited by 43 publications

References 41 publications

Using imaging as a biomarker for asthma

Using imaging as a biomarker for asthma

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system

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Assessment of Regional Lung Function with Multivolume¹H MR Imaging in Health and Obstructive Lung Disease: Comparison with³He MR Imaging