Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model

Chen, Szu-Hsien; Tsao, Ching-Ting; Chang, Chien Hsin; Lai, Yi‐Ting; Wu, Ming-Fung; Chuang, Ching-Nan; Chou, Hung-Chia; Wang, Chih-Kuang; Hsieh, Kuo-Haung

doi:10.1016/j.msec.2013.02.031

Cited by 83 publications

(42 citation statements)

References 27 publications

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“…Due to easy applicability, water sorptivity, oxygen permeability, blood coagulating property, and cytokine induction (interleukin-8) which activate the fibroblast migration and proliferation, it is used as wound dressing material. 75 6.1.5 Alginate. Alginate is a heteropolysaccharide found in brown algae composed of D-mannuronic acid (M) and D-guluronic acid (G) residues.…”

Section: Carboxymethyl Cellulosementioning

confidence: 99%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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Dermal tissue engineering focuses on the restoration of diseased and damaged tissues by using a combination of cells, biomaterials, and bioactive molecules. Inorganic substances like zeolites, clay, mesoporous silica, metals, and metal oxides are advanced materials used in wound healing research. They can improve the structural stability and bioactivity of bio polymeric scaffolds. Zeolites, clays, and mesoporous silica act as suitable carriers for drug delivery and when incorporated within scaffolds, serve as ideal matrices for promoting skin regeneration. This review focuses on various natural polymers/inorganic materials based composite scaffolds used for skin tissue engineering, highlighting their synthesis routes and mode of action by which wound healing is enhanced. Among the different inorganic materials used, the role of zeolites incorporated biocomposites for promoting blood coagulation, antibacterial effect; oxygen delivery to cells and wound healing are discussed in detail. The article thus includes recent attempts to explore the hidden potential of inorganic materials in dermal tissue engineering.

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Section: Carboxymethyl Cellulosementioning

confidence: 99%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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“…Chen et al [114] prepared reinforced poly(ethylene glycol) (PEG)-CS (RPC) hydrogels with different Mw (600, 1000 and 2000 Da) of PEG and different molar ratios of carboxylic acid to amine group (5:95, 10:90, and 15:85, neat CS). 1000-RP10C90 has good mechanical strength and proper degradation rates.…”

Section: Wound Dressings With Chitosan and Synthetic Polymersmentioning

confidence: 99%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

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“…Cross-linked chitosan with polyethylene glycol [4,14] Смесь хитин + хитозан + альгинаты Chitin + chitosan + аlginates mixture Фукоидан Fucoidan [5] Смесь хитин + желатин Chitin + gelatin mixture Мед Honey [6] Графтирование эпоксипропилтриметиламмония хлоридом Epoxypropyltrimethylammonium grafting with chloride [7] Нанофибрилы хитина/гликолат/хитозан Chitin/glycolate/chitosan nanofibrils Хлоргексидин Chlorhexidine [8] Хитин/поливинилпирролидон Chitin/polyvinylpyrrolidone TiO 2 [9] Хитозан с различной степенью деацетилирования…”

Section: поперечносшитый хитозан с полиэтиленгликолемunclassified