Assessment of renal fibrosis in chronic kidney disease using diffusion-weighted MRI

Zhao, Jingbo; Wang, Z.J.; Liu, M.; Zhu, Jian; Zhang, X.; Zhang, T.; Li, S.; Li, Y.

doi:10.1016/j.crad.2014.06.011

Cited by 136 publications

(143 citation statements)

References 23 publications

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“…Similar findings were reported by Zhao et al, but in their study of 35 patients with CKD (25 who had renal biopsies showing chronic GN), GFR and renal biopsy fibrosis scores did correlate with ADC [4]. Using DTI, a lower FA has been shown to be associated with the magnitude of GFR reduction and degree of fibrosis on renal biopsy in patients with GN (CKD stage 1-3), although there was less clear separation of FA values between CKD stages as compared to ADC values [5].…”

Section: Diffusion-weighted Mrisupporting

confidence: 76%

Imaging the kidney using magnetic resonance techniques

Mahmoud

Buchanan

Francis

et al. 2016

Current Opinion in Nephrology and Hypertension

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(2016) Imaging the kidney using magnetic resonance techniques: structure to function. Current Opinion in Nephrology and Hypertension, 25 (6). pp. 487-493. ISSN 1473-6543 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39487/1/REVIEW_RENAL_EPRINTS_ALL.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Recent findingsA number of MRI techniques have been developed that provide non-invasive measures of relevance to the pathophysiology of kidney disease. Diffusion-weighted imaging (DWI) has been used in chronic kidney disease (CKD) and renal transplantation, and appears promising as a measure of renal impairment and fibrosis. Longitudinal relaxation time (T1) mapping has been utilised in cardiac MRI to measure fibrosis and oedema; recent work suggests its potential for assessment of the kidney. Blood oxygen level dependent (BOLD) MRI to measure renal oxygenation has been extensively studied, but a number of other factors affect results making it hard to draw definite conclusions as to its utility as an independent measure. Phase contrast and arterial spin labelling (ASL) can measure renal artery blood flow and renal perfusion respectively without exogenous contrast, in contrast to dynamic contrast enhanced (DCE) studies. Current data on clinical use of such functional renal MR measures is largely restricted to cross-sectional studies. SummaryRenal MRI has seen significant recent interest and advances. Current evidence demonstrates its potential, and next steps include wider evaluation of its clinical application.3

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Section: Diffusion-weighted Mrisupporting

confidence: 76%

Imaging the kidney using magnetic resonance techniques

Mahmoud

Buchanan

Francis

et al. 2016

Current Opinion in Nephrology and Hypertension

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“…However, based on renal cortical-medullary tissue and cellar structure and physiological functional discrepancies, we could detect the more serious renal parenchymal fibrosis located in the medullary area. Previous studies have shown a correlation between decreased ADC and the magnitude of fibrosis [24,25]. However, other studies have shown the opposite effect with D p .…”

Section: Discussionmentioning

confidence: 59%

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Zhao

Yan

Jia

et al. 2018

Kidney Blood Press Res

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Background/Aims: Renal pathological changes affect the motion of water molecules, which can be detected using diffusion-weighted imaging (DWI). The current study was performed to explore the correlation between renal tissue pathological injuries and DWI iconographical parameters in lupus nephritis (LN). Methods: Twenty adult patients with LN and 11 healthy volunteers were recruited. Patients with LN received renal biopsies and renal DWI-MRI inspections. The renal biopsy tissues were characterized based on the ISN/RPS 2003 classification. The volunteers, who were of comparable gender and age, only underwent renal DWI-MRI inspection. Four DWI parameters, namely, apparent diffusion coefficient (ADC), pure diffusion coefficient (D_t), pseudo-diffusion coefficient (D_p), and perfusion fraction (f_p), were calculated using monoexponential and biexponential functions, respectively. Data from different renal areas and pathological pattern groups were compared. Multiple correspondence analysis (MCA) was performed to explore the correlation between each DWI index and multiple pathological features. Results: ADC, D_t, and f_p values were lower in the LN group compared to the controls (P < 0.001) regardless of the renal area in the cortex and medulla. D_p values were higher in the LN group (P = 0.004). A difference in mean DWI parameters was found between three LN subgroups and the healthy volunteers, with the exception of the D_p index in the renal cortex. MCA showed that serious proliferative pathological injuries and lower ADC and D_t values were located in the same quadrant. The MCA plots of D_p and f_p provided similar results. Higher D_p and f_p values were located in the MCA plot quadrant with more serious proliferative pathological changes. Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.

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“…MRI examination was performed using a 1.5 T unit (Ingenia, Philips, The Netherlands) with a posterior body coil embedded into the 15 FA, number of sections¼22, section thickness¼5 mm) sequences, and transverse in-phase, out-of-phase, and fatand water-saturated mDixon (6 ms TR, 2.3 ms TE, 15 FA, number of sections¼95, section thickness¼4 mm) through the upper and middle abdomen. In potential living kidney donors, the protocol included heavily weighted T2-wighted images of the kidneys for the detection of small renal cysts and intravenous administration of contrast medium for MR perfusion and MR angiography to assess renal function and vasculature.…”

Section: Mri Examinationmentioning

confidence: 99%