Assessment of river contamination by estrogenic compounds in Paris area (France)

Cargouët, Maëlle; Perdiz, Daniel; Mouatassim-Souali, Asmaa; Tamisier-Karolak, Sara L.; Lévi, Yves

doi:10.1016/j.scitotenv.2003.10.035

Cited by 340 publications

(136 citation statements)

References 39 publications

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“…In Dutch surface waters both analytes were detected mostly under the limit of quantification (<0.1 ng/L) (Belfroid et al 1999). In river samples in the Paris area (France) 1.4 to 3.0 mean E2 and 1.1 to 2.9 mean EE2 was found (Cargouet et al 2004). Hungarian scientists reported contamination in the River Danube earlier.…”

Section: Discussionmentioning

confidence: 99%

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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17β-estradiol (E2) and 17α-ethinyl estradiol (EE2), which are environmental estrogens have been determined with LC-MS in freshwater. Their sensitive analysis needs derivatisation and therefore is very hard to achieve in multiresidue screening. We analysed samples from all the large and some small rivers (River Danube, Drava, Mur, Sava, Tisza and Zala) of the Carpathian Basin and from Lake Balaton. Freshwater was extracted on solid phase and derivatised using dansyl-chloride. Separation was performed on a Kinetex XB-C18 column. Detection was achieved with a benchtop orbitrap mass spectrometer using targeted MS analysis for quantification. Limits of quantification were 0.05 ng/L (MS1) and 0.1 ng/L (MS/MS) for E2, and 0.001 ng/L (MS1) and 0.2 ng/L (MS/MS) for EE2. River samples contained n.d.-5.2 ng/L E2 and n.d.-0.68 ng/L EE2. Average levels of E2 and EE2 were 0.61 and 0.084 ng/L respectively in rivers, water courses and Lake Balaton together, but not counting city canal water. EE2 was less abundant, but it was still present in almost all of the samples. In beach water samples from Lake Balaton we measured 0.076-0.233 E2 and n.d.-0.133 EE2. A relative high amount of EE2 was found in river Zala (0.68 ng/L) and in Hévíz-Páhoki canal (0.52 ng/L), which are both in the catchment area of Lake Balaton (Hungary). HighlightsMethod is proposed for simultaneous determination of 17β-estradiol and 17α-ethinyl estradiol. Derivatization is necessary to reach low LOQ. Low ng/L presence of estrogens in selected European Rivers has been detected.

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Section: Discussionmentioning

confidence: 99%

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Avar

Zrínyi²,

Maász

et al. 2016

Environ Sci Pollut Res

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“…Another source of hormonal activity in groundwater may be the reflux of synthetic estrogens like 17α-ethinylestradiol and other pharmaceuticals from wastewater discharge. Although shown for surface water (Cargouet et al 2004), no clear evidence for the entry of 17α-ethinylestradiol in groundwater is available up to now.…”

Section: Discussionmentioning

confidence: 99%

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Wagner

Oehlmann

2009

Environ Sci Pollut Res

294

178

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Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g., phthalates) and human body fluids (e.g., urine and blood). Since the research in this field is focused on few chemicals (and thus missing mixture effects), the overall contamination of edibles with xenohormones is largely unknown. The aim of this study was to assess the integrated estrogenic burden of bottled mineral water as model foodstuff and to characterize the potential sources of the estrogenic contamination. Materials, methods, and results In the present study, we analyzed commercially available mineral water in an in vitro system with the human estrogen receptor alpha and detected estrogenic contamination in 60% of all samples with a maximum activity equivalent to 75.2 ng/l of the natural sex hormone 17β-estradiol. Furthermore, breeding of the molluskan model Potamopyrgus antipodarum in water bottles made of glass and plastic [polyethylene terephthalate (PET)] resulted in an increased reproductive output of snails cultured in PET bottles. This provides first evidence that substances leaching from plastic food packaging materials act as functional estrogens in vivo.Discussion and conclusions Our results demonstrate a widespread contamination of mineral water with xenoestrogens that partly originates from compounds leaching from the plastic packaging material. These substances possess potent estrogenic activity in vivo in a molluskan sentinel. Overall, the results indicate that a broader range of foodstuff may be contaminated with endocrine disruptors when packed in plastics.

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“…There are indications from UK studies that STW remove 38-83% of the E2 in the influent whilst Stumpf et al (1996) reported 58-91% removal of steroids in German STWs. Estimates for STW serving the Paris region suggest removal rates of 43-60% for E2 and 38-45% for EE2 (Cargouet et al, 2004).…”

Section: Figure 1 Near Herementioning

confidence: 99%

“…Comparisons with chemical data revealed similar trends, although the accurate prediction of biological responses, based on concentrations and oestrogenic potencies of compounds, has yet to be achieved widely. A complex variety of mechanisms (including the presence of unquantified compounds) may confound straightforward relationships between measured concentrations of known oestrogens and in vitro responses (Cargouet et al, 2004).…”

Section: In Vitro and In Vivo Assays And Biomarkers Of Oestrogenicitymentioning

confidence: 99%

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

et al. 2005

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This review provides insights into the distribution and impact of oestrogens and xenooestrogens in the aquatic environment and highlights some significant knowledge gaps in our understanding of endocrine disrupting chemicals. Key areas of uncertainty in the assessment of risk include the role of estuarine sediments in mediating the fate and bioavailability of environmental (xeno)oestrogens (notably their transfer to benthic organisms and estuarine food chains), together with evidence for endocrine disruption in invertebrate populations.Emphasis is placed on using published information to interpret the behaviour and effects of a small number of 'model compounds' thought to contribute to oestrogenic effects in nature; namely, the natural steroid 17β-estradiol (E2) and the synthetic hormone 17α-ethinylestradiol (EE2), together with the alkylphenols octyl-and nonylphenol (OP, NP) as oestrogen mimics. Individual sections of the review are devoted to sources and concentrations of (xeno)oestrogens in waterways, sediment partitioning and persistence, bioaccumulation rates and routes, assays and biomarkers of oestrogenicity, and, finally, a synopsis of reproductive and ecological effects in aquatic species.

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Assessment of river contamination by estrogenic compounds in Paris area (France)

Cited by 340 publications

References 39 publications

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

β-Estradiol and ethinyl-estradiol contamination in the rivers of the Carpathian Basin

Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

Partitioning, bioavailability and effects of oestrogens and xeno-oestrogens in the aquatic environment

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