Assessment of safety and feasibility of human allogeneic adipose-derived mesenchymal stem cells in a pediatric patient

Hirano, Atsuyuki; Sano, Masayuki; Urushihata, Naoki; Tanemura, Hideki; Oki, Katsuyuki; Suzaki, Emi

doi:10.1038/s41390-018-0042-8

Cited by 12 publications

(30 citation statements)

References 15 publications

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“…These conditions are consequences from a combination of metabolic derangements and cerebral microthrombi [46]. The patient in the study developed CP on the left side of his body because his right thalamus putamen zone was involved in the infarcted area [44].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 96%

“…Due to their pluripotential properties, human adipose-derived mesenchymal stem cells (hAd-MSC) can differentiate into various types of cells: adipocytes, myocytes, chondrocytes, and osteocytes [44]. One study determined the safety and efficacy of allogeneic hAd-MSC administration in a 7-year-old boy with CP [44]. At the age of 2, he had cerebral infarction due to hemolytic uremic syndrome (HUS) following Escherichia coli O-157 infection [44].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…One study determined the safety and efficacy of allogeneic hAd-MSC administration in a 7-year-old boy with CP [44]. At the age of 2, he had cerebral infarction due to hemolytic uremic syndrome (HUS) following Escherichia coli O-157 infection [44]. HUS involves microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency [45].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…Adipose tissue was harvested from the peri-umbilical area of the patient's mother [44]. With a total amount of 22 grams of fatty tissue, allogeneic hAd-MSCs were isolated using a combination of enzymatic digestion and centrifugation [44]. Depending on their capacity to adhere to the surface of plastic culture flasks, certain hAd-MSCs were selected [44].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

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2020

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As the gestational age at birth decreases, the risk of the infant having CP increases [6]. Detections of CP among premature births are mostly found through white matter damage on brain-imaging modalities [6]. Evidence of single or multiple brain lesions or ventriculomegaly in a pre-term infant leads to a 50% risk of developing CP [6]. The prenatal Abstract Cerebral palsy (CP) is a neurodevelopmental disorder that hinders normal motor activity and muscle coordination. CP typically appears before, during, or soon after birth as the brain is still developing. The severity of this multifactorial condition depends on the damage done to the parts of the brain that control muscle tone and body movement. The insult in the underdeveloped brain prohibits normal growth; neurons and oligodendrocytes will either die or fail to develop, and the white matter tracts that connect various brain regions become malfunctional. Cerebral palsy is classified into different types depending on the areas of the brain that were insulted and the nature of the movement disorder: spasticity, dyskinesia, and ataxia. Abnormal brain development in patients with CP cannot be reversed, but various treatments are shown to improve and normalize the symptoms. Stem cell transplantation, a regenerative therapy that can replace the damaged and non-functional cells of the brains in CP patients, has shown effective results. Embryonic stem cells (ESC), mesenchymal stem cells (MSC), hematopoietic stem cells (HSC), human amnion epithelial cells (hAEC), and neural stem cells (NSC) are infused to reproduce into more specialized cell types. This alternative therapeutic method has shown successful results through preclinical animal research and clinical trials.

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Section: Mesenchymal Stem Cellsmentioning

confidence: 96%