Assessment of Selected Overdose Poisoning Indicators in Health Care Administrative Data in 4 States, 2012

Hume, Benjamin C. C.; Gabella, Barbara; Hathaway, Jeanne; Proescholdbell, Scott; Sneddon, Cristy; Brutsch, Elizabeth; Hedin, Riley J.; Drucker, Christopher

doi:10.1177/0033354917718061

Cited by 5 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We used the broadest definition, "drug poisonings associated with opium, heroin, and opioid analgesics or opioid adverse effect, or abuse/dependence" to identify acute adverse events from opioid use or the presence of underlying OUD. Both principal and secondary diagnosis codes were included to maximize sensitivity (20). We augmented diagnosis-based case finding by including inpatient administrations of buprenorphine as an additional indicator of opioid-related hospitalizations.…”

Section: Identifying Patients With Sepsis and Opioid-related Hospital...mentioning

confidence: 99%

Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals*

Alrawashdeh

Kimmel

Larochelle

et al. 2021

Critical Care Medicine

View full text Add to dashboard Cite

OBJECTIVES: Widespread use and misuse of prescription and illicit opioids have exposed millions to health risks including serious infectious complications. Little is known, however, about the association between opioid use and sepsis. DESIGN: Retrospective cohort study. SETTING: About 373 U.S. hospitals. Patients: Adults hospitalized between January 2009 and September 2015. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Sepsis was identified by clinical indicators of concurrent infection and organ dysfunction. Opioid-related hospitalizations were identified by the International Classification of Diseases, 9th Revision, Clinical Modification codes and/or inpatient orders for buprenorphine. Clinical characteristics and outcomes were compared by sepsis and opioid-related hospitalization status. The association between opioid-related hospitalization and all-cause, in-hospital mortality in patients with sepsis was assessed using mixed-effects logistic models to adjust for baseline characteristics and severity of illness. The cohort included 6,715,286 hospitalizations; 375,479 (5.6%) had sepsis, 130,399 (1.9%) had opioid-related hospitalizations, and 8,764 (0.1%) had both. Compared with sepsis patients without opioid-related hospitalizations (n = 366,715), sepsis patients with opioid-related hospitalizations (n = 8,764) were younger (mean 52.3 vs 66.9 yr) and healthier (mean Elixhauser score 5.4 vs 10.5), had more bloodstream infections from Gram-positive and fungal pathogens (68.9% vs 47.0% and 10.6% vs 6.4%, respectively), and had lower in-hospital mortality rates (10.6% vs 16.2%; adjusted odds ratio, 0.73; 95% CI, 0.60–0.79; p < 0.001 for all comparisons). Of 1,803 patients with opioid-related hospitalizations who died in-hospital, 928 (51.5%) had sepsis. Opioid-related hospitalizations accounted for 1.5% of all sepsis-associated deaths, including 5.7% of sepsis deaths among patients less than 50 years old. From 2009 to 2015, the proportion of sepsis hospitalizations that were opioid-related increased by 77% (95% CI, 40.7–123.5%). CONCLUSIONS: Sepsis is an important cause of morbidity and mortality in patients with opioid-related hospitalizations, and opioid-related hospitalizations contribute disproportionately to sepsis-associated deaths among younger patients. In addition to ongoing efforts to combat the opioid crisis, public health agencies should focus on raising awareness about sepsis among patients who use opioids and their providers.

show abstract

Section: Identifying Patients With Sepsis and Opioid-related Hospital...mentioning

confidence: 99%

Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals*

Alrawashdeh

Kimmel

Larochelle

et al. 2021

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

Association of Early Opioid Withdrawal Treatment Strategy and Patient-Directed Discharge Among Hospitalized Patients with Opioid Use Disorder

et al. 2023

View full text Add to dashboard Cite

Comparison of hospital claims and poison center data to evaluate health impact of opioids, cannabis and synthetic cannabinoids

Wang

Buttorff

Wilks

et al. 2022

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Assessment of Selected Overdose Poisoning Indicators in Health Care Administrative Data in 4 States, 2012

Cited by 5 publications

References 7 publications

Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals*

Epidemiology, Outcomes, and Trends of Patients With Sepsis and Opioid-Related Hospitalizations in U.S. Hospitals*

Association of Early Opioid Withdrawal Treatment Strategy and Patient-Directed Discharge Among Hospitalized Patients with Opioid Use Disorder

Comparison of hospital claims and poison center data to evaluate health impact of opioids, cannabis and synthetic cannabinoids

Contact Info

Product

Resources

About