Assessment of sensory neuropathy in diabetic patients without diabetic foot problems

Nather, Aziz; Neo, Shu Hui; Chionh, Siok Bee; Liew, Stanley C.F.; Sim, Eileen Yilin; Chew, Jocelyn L.L.

doi:10.1016/j.jdiacomp.2006.10.007

Cited by 45 publications

(27 citation statements)

References 9 publications

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“…Meanwhile, C fibers primarily conduct impulses for temperature and pain and play a role in the autonomic nervous system. A few studies involving a small number of patients with diabetes have validated the use of CPT to detect DPN [5,6,7,8,9]. In the present study, we evaluated the usefulness of CPT for the diagnosis of DPN and for the diagnosis of cardiovascular autonomic neuropathy (CAN) compared with conventional tests in a large number of Korean patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus

et al. 2014

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BackgroundThe current perception threshold (CPT) could be quantified by stimulating Aβ and C fibers at 2,000 and 5 Hz, respectively. C fibers play a role in the autonomic nervous system and are involved in temperature and pain sensation. We evaluated the usefulness of CPT for diagnosing distal polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) in diabetic patients.MethodsThe CPT was measured in the index finger (C7 level) and in the third toe (L5 level) in diabetic patients aged 30 to 69 years. We assessed DPN according to the neuropathy total symptom score-6 (NTSS-6) and 10-g monofilament pressure sensation. Subjects with a NTSS-6 >6 or with abnormal 10-g monofilament sensation were defined to have DPN. CAN was evaluated by spectral analysis of heart rate variability and by Ewing's traditional tests.ResultsThe subjects with DPN had significantly higher CPT at all of the frequencies than the subjects without DPN (P<0.05). Abnormal 10-g monofilament sensation and NTSS-6 >6 could be most precisely predicted by CPT at 2,000 and 5 Hz, respectively. However, only 6.5% and 19.6% of subjects with DPN had an abnormal CPT at 2,000 Hz at the C7 and L5 levels. Although CPT at 5 Hz showed a negative correlation with the power of low and high frequency in the spectral analysis (P<0.05), only 16.7% of subjects with CAN exhibited an abnormal CPT at the same frequency.ConclusionAlthough the CPT is significantly associated with neuropathic symptoms or signs corresponding to the nerve fiber stimulated, it provides little additional information compared with conventional evaluations.

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Section: Introductionmentioning

confidence: 99%

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus

et al. 2014

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“…The subject was asked to always report when he/she felt the touch. The test is defined as positive in the presence of insensitivity to the 10-g monofilament 17 .…”

Section: Methodsmentioning

confidence: 99%

Estabilidade da marcha na neuropatia diabética periférica

Fortaleza¹,

Chagas

Ferreira

et al. 2014

Rev. Bras. Cineantropom. Desempenho Hum.

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-The aim of this study was to evaluate gait stability in diabetic patients with peripheral neuropathy in three conditions: habitual walking with eyes open, walking with eyes closed, and walking with eyes open and narrow base of support. The study included 41 subjects, 18 with neuropathy (NG) and 23 controls. Gait stability was evaluated on a baropodometer using the Footwalk Pro software. The following data were obtained: gait speed and percentage of time spent in double stance and single stance. Significant differences were observed between groups in all three conditions for gait speed and single stance time, which were reduced in NG (p<0.05), and for double stance time, which was increased in NG (p<0.05). For gait speed, double stance time and single stance time, the eyes open condition differed from the eyes closed (p<0.001) and narrow base of support (p<0.001) conditions. In the three conditions studied, patients of NG presented a deficit in gait stability and this performance was even more compromised in the two conditions that required greater postural control. These gait changes resulting from the complexity imposed by the different conditions suggest the inclusion of these conditions in the evaluation and treatment of this population. Key words: Balance; Diabetic neuropathies; Gait; Physiotherapy. Resumo -O objetivo do estudo foi verificar a estabilidade da marcha em diabéticos com neuropatia periférica, em três situações: marcha habitual com os olhos abertos; marcha com os olhos fechados e marcha com olhos abertos e diminuição da base de sustentação. Participaram do estudo 41 indivíduos, sendo 18 do grupo neuropata (GN) e 23 do grupo controle (GC). 428Gait stability in diabetic neuropathy Fortaleza et al.

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“…The Neurometer Ò (Neurotron, Inc., Baltimore, MD, USA) is an example of such a device; it has been used clinically to detect peripheral neuropathy in diabetic individuals. [1][2][3][4][5][6][7] By measuring CPT and CPT trends, transcutaneous nerve stimulation has been suggested as an effective tool in diagnosing and monitoring conditions associated with worsening peripheral neuropathy (i.e., increasing CPT values), such as diabetes mellitus or vibration-induced neuropathy. 2 Current standard techniques for determining nerve block effectiveness are limited by the inherent subjectivity of patient self-reporting (e.g., cold test, pinprick tests).…”

Section: Résumémentioning

confidence: 99%

Reproducibility of current perception threshold with the Neurometer® vs the Stimpod NMS450 peripheral nerve stimulator in healthy volunteers: an observational study

Tsui

Shakespeare

Leung

et al. 2013

Can J Anesth/J Can Anesth

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Assessment of sensory neuropathy in diabetic patients without diabetic foot problems

Cited by 45 publications

References 9 publications

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus

Estabilidade da marcha na neuropatia diabética periférica

Reproducibility of current perception threshold with the Neurometer® vs the Stimpod NMS450 peripheral nerve stimulator in healthy volunteers: an observational study

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