Assessment of Serum CoQ10 Levels and other Antioxidant Markers in Breast Cancer

El-Attar, Eman; Kamel, Amel; Karmouty, Ahmed; Wehida, Nadine; Nassra, Rasha A.; Nemr, Mohamed El; Kandil, Noha Said

doi:10.31557/apjcp.2020.21.2.465

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…Studies on the use of serum survivin levels as a diagnostic marker have shown that patients with hepatocellular carcinoma and acute lymphoblastic leukemia have higher serum survivin levels than healthy individuals. [27–30] However, in contrast to these studies, some studies in patients with lung cancer did not show a significant increase in serum survivin levels. [28,66] Since the aim of our study was to examine the relationship between survivin levels, survival, and response to treatment in patients with MPC, survivin was not evaluated as an early diagnosis marker.…”

Section: Discussionmentioning

confidence: 92%

“…From this point of view, survivin levels may also have diagnostic value . [27][28][29][30] Following determining the serum levels of basal survivin in patients with metastatic pancreatic cancer (MPC), we analyzed the correlations between this level and the clinicopathological features of the patients in our study. We also investigated the relationships between the survivin level with prognosis and treatment response.…”

Section: Introductionmentioning

confidence: 99%

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Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

et al. 2023

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In the present study, we aimed to assess the association between the serum survivin level and overall survival and treatment response rates in metastatic pancreatic cancer (MPC). Serum samples were prospectively collected from 41 patients with newly diagnosed MPC patients and 41 healthy individuals (control group) to assess the survivin levels. The median survivin level was 136.2 ng/mL in patients with MPC and 52 ng/mL in healthy individuals (P = .028). Patients were divided into low- and high-survivin groups according to the baseline median survivin level. Patients with a high serum survivin level compared with a low serum survivin level had shorter median progression-free survival (2.39 vs 7.06 months; P = .008, respectively) and overall survival (3.74 vs 9.52 months; P = .026, respectively). Patients with higher serum survivin levels had significantly worse response rates (P = .007). The baseline high level of serum survivin in patients with MPC may be associated with treatment resistance and poor prognosis. A confirmation will be needed for these results in future large multicenter prospective studies.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

et al. 2023

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“…It is caused by complex, interconnected risk factors. One of the most important factors is the genetic and epigenetic factors (El-Attar et al, 2020). The progression of BC depends on intrinsic factors related to the tumor cells, such as transcription factors.…”

Section: Discussionmentioning

confidence: 99%

The Role of miRNA-182 and FOXO3 Expression in Breast Cancer

Kandil

Mohamed

et al. 2022

Asian Pac J Cancer Prev

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Objective: evaluating the role of FOXO3 mRNA and mi RNA 182-5P expression levels in BC patients. Method: 25 Samples of breast cancer and paired samples of non-cancerous tissues from the same resected breast were obtained from 25 female patients suffering from breast cancer and examined and analyzed by real time PCR to detect the expression levels of FOXO3 mRNA and mi RNA 182-5P. Patients' data were collected from patients medical records. Results: Foxo3 m RNA expression was down regulated in BC tissues (1.37± 1.96) as compared to control group (23.62 ± 54.39) and decreased FOXO3 expression was associated with larger tumor size (p= 0.046), late histopathological grading (p= 0.002), late TNM staging (<0.001) and increased miR-182 expression (p= 0.025).We found that expression level of miR-182 was significantly higher among breast cancer group (1.10±1.15) as compared to the control group (0.58±0.96 ) with p value = 0.017. We noted a significant increased expression associated with larger tumor size (p= 0.002), late histopathological grading (p= 0.008), late TNM staging (p= 0.002) and decreased FOXO3 expression (p= 0.025). A significant negative correlation between miR-182 and FOXO3 mRNA fold expression with r = -0.447, and a p value of 0.025, this could be attributed to miRNA targeting FOXO gene. Coclusion: Down regulation of FOXO3 and up regulation of miR-182 expression was associated with advanced breast cancer. The negative correlation between miR-182 and FOXO3 mRNA could be attributed to miRNA targeting FOXO gene.

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“…It is a benzoquinone containing a 50-carbon isoprenoid side chain with ten isoprenyl units in its side chain. Its solubility in water is very low (0.7 ng/mL) due to its high molecular weight (863) and high lipophilicity [12]. Ubiquinone is an essential cofactor in the production of ATP during oxidative phosphorylation.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ubiquinone on Oxidant and Antioxidant Status in Hepatocellular Carcinoma Cell Line

Heidari-Kalvani

Fallah

Barjasteh

et al. 2023

IJML

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Background and Aims: The concomitant use of antioxidants during chemotherapy is controversial. It is unknown whether antioxidants increase or decrease the effectiveness of anticancer drugs. Therefore, the present study aimed to investigate ubiquinone's cytotoxic and antioxidant effects on the HepG2 cell line. Materials and Methods: The HepG2 cell line was chosen as an experimental model for hepatocellular carcinoma in this study. The cytotoxic effect of ubiquinone was assessed as a function of time and concentration using the colorimetric MTT assay. The half-maximal inhibitory concentration (IC50) was determined to assess the cytotoxic effects of different ubiquinone concentrations. The protective impacts of ubiquinone on HepG2 cells were evaluated by assessing the oxidative stress profile. Results: The MTT showed that the IC50 after treatment with ubiquinone was 350 and 335 μM at 24 and 48 hours, respectively. Evaluation of redox homeostasis in HepG2 cells using three doses of ubiquinone, including IC50 and one dose higher and one dose lower than IC50, showed a decrease in oxidative stress and an increase in the antioxidant capacity of HepG2 cells in a dose-dependent manner (p < 0.01). An increase in redox hemostasis decreased the viability of HepG2 cells. Conclusion: Our results showed ubiquinone could reduce cancer cell survival by interfering in redox oxidative-redox status. Therefore, ubiquinone can be used as an antioxidant supplement along with chemotherapy drugs.

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Assessment of Serum CoQ10 Levels and other Antioxidant Markers in Breast Cancer

Abstract: It can make an impact on the different stages of cancer development (Jomova and Valko, 2011). It can alter the DNA sequence in the initiation step, increase cell division/ reduce apoptosis in the promotion stage and can also promote additional changes to the DNA in the progression

Cited by 9 publications

References 28 publications

Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

The Role of miRNA-182 and FOXO3 Expression in Breast Cancer

Effects of Ubiquinone on Oxidant and Antioxidant Status in Hepatocellular Carcinoma Cell Line

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